Heart Dysfunction in Essential Hypertension Depends on Systemic Proinflammatory Influences: A Retrospective Clinical Pathophysiological Study.
6 min walk test
chronic heart failure
correlation analysis
diastolic dysfunction
essential arterial hypertension
preserved ejection fraction
proinflammatory status
sex differences
Journal
Pathophysiology : the official journal of the International Society for Pathophysiology
ISSN: 1873-149X
Titre abrégé: Pathophysiology
Pays: Switzerland
ID NLM: 9433813
Informations de publication
Date de publication:
07 Aug 2022
07 Aug 2022
Historique:
received:
08
07
2022
revised:
04
08
2022
accepted:
04
08
2022
entrez:
23
8
2022
pubmed:
24
8
2022
medline:
24
8
2022
Statut:
epublish
Résumé
Low-intensity systemic inflammation is an important element of heart failure pathogenesis. The aim of this study is to assess proinflammatory status serum indicators (C-reactive protein (CRP), tumor necrosis factor alpha (TNF-α), interleukin-6 (IL-6)) in middle-aged males (M) and females (F) with essential hypertension (HTN) depending on left ventricular (LV) diastolic dysfunction (LVDD). The main group comprised 55 M and 49 F with the first- to second-severity grade HTN with mild heart failure and a preserved LV ejection fraction ≥50%. Patients had sinus rhythm, first or second-severity degree LVDD, LV hypertrophy, left atrium dilatation, and NT-proBNP > 125 pg/mL. Comparison group: 30 hypertensives without cardiac dysfunction; control group: 31 normotensives. Quantitative features were compared using the Mann−Whitney test, median χ2, ANOVA module. Spearman’s rank correlation coefficients were determined to identify the relationship between the proinflammatory pattern and exercise tolerance. Hypertensive M had markedly higher CRP, TNF-α, and IL-6 levels compared to F. All mean values corresponded to reference range. In patients with second-degree LVDD, CRP, TNF-α, and IL-6 levels were significantly greater than in subjects with first-degree LVDD (both within M and within F samples). Significant negative associations between CRP, IL-6, and TNF-α levels and the 6 min walk test existed in hypertensive M and F. The study demonstrated a close relationship between the proinflammatory pattern and LVDD and exercise tolerance indicators, regardless of the hypertensive patient’s sex.
Identifiants
pubmed: 35997392
pii: pathophysiology29030036
doi: 10.3390/pathophysiology29030036
pmc: PMC9396991
doi:
Types de publication
Journal Article
Langues
eng
Pagination
453-468Subventions
Organisme : Government of Russian Federation for state sup-port of scientific research carried out under the supervision of leading scientists
ID : 075-15-2022-1110
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