Discovery of Novel Quinoline-Based Proteasome Inhibitors for Human African Trypanosomiasis (HAT).


Journal

Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531

Informations de publication

Date de publication:
08 09 2022
Historique:
pubmed: 23 8 2022
medline: 11 9 2022
entrez: 22 8 2022
Statut: ppublish

Résumé

Human African Trypanosomiasis (HAT) is a vector-borne disease caused by kinetoplastid parasites of the

Identifiants

pubmed: 35993839
doi: 10.1021/acs.jmedchem.2c00791
pmc: PMC9469205
doi:

Substances chimiques

Proteasome Inhibitors 0
Quinolines 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

11776-11787

Subventions

Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/S019650/1
Pays : United Kingdom
Organisme : Wellcome Trust
ID : WT-103024MA
Pays : United Kingdom
Organisme : Wellcome Trust
ID : WT-104976
Pays : United Kingdom

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Auteurs

Dennis C Koester (DC)

Global Discovery Chemistry, Novartis Institutes for Biomedical Research, Emeryville, California 94608, United States.

Vanessa M Marx (VM)

Global Discovery Chemistry, Novartis Institutes for Biomedical Research, Emeryville, California 94608, United States.

Sarah Williams (S)

Global Discovery Chemistry, Novartis Institutes for Biomedical Research, Emeryville, California 94608, United States.

Jan Jiricek (J)

Global Discovery Chemistry, Novartis Institutes for Biomedical Research, Emeryville, California 94608, United States.

Maxime Dauphinais (M)

Global Discovery Chemistry, Novartis Institutes for Biomedical Research, Emeryville, California 94608, United States.

Olivier René (O)

Global Discovery Chemistry, Novartis Institutes for Biomedical Research, Emeryville, California 94608, United States.

Sarah L Miller (SL)

Global Discovery Chemistry, Novartis Institutes for Biomedical Research, Emeryville, California 94608, United States.

Lei Zhang (L)

Global Discovery Chemistry, Novartis Institutes for Biomedical Research, Emeryville, California 94608, United States.

Debjani Patra (D)

Novartis Institutes for Tropical Diseases, Emeryville, California 94608, United States.

Yen-Liang Chen (YL)

Lead Discovery, Novartis Institutes for Tropical Diseases, Emeryville, California 94608, United States.

Harry Cheung (H)

Lead Discovery, Novartis Institutes for Tropical Diseases, Emeryville, California 94608, United States.

Jonathan Gable (J)

Lead Discovery, Novartis Institutes for Tropical Diseases, Emeryville, California 94608, United States.

Suresh B Lakshminarayana (SB)

Pharmacokinetic Sciences, Novartis Institutes for Tropical Diseases, Emeryville, California 94608, United States.

Colin Osborne (C)

Pharmacokinetic Sciences, Pharmacology and Comparative Medicine, Novartis Institutes for Tropical Diseases, Emeryville, California 94608, United States.

Jean-Rene Galarneau (JR)

Preclinical Safety, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts 02139, United States.

Upendra Kulkarni (U)

Chemical and Pharmaceutical Profiling, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts 02139, United States.

Wendy Richmond (W)

Global Discovery Chemistry, Novartis Institutes for Biomedical Research, San Diego, California 92121, United States.

Angela Bretz (A)

Global Discovery Chemistry, Novartis Institutes for Biomedical Research, San Diego, California 92121, United States.

Linda Xiao (L)

Pharmacology, Novartis Institutes for Tropical Diseases, Emeryville, California 94608, United States.

Frantisek Supek (F)

Novartis Institutes for Biomedical Research, San Diego, California 92121, United States.

Christian Wiesmann (C)

Novartis Institutes for Biomedical Research, 4056 Basel, Switzerland.

Srinivas Honnappa (S)

Novartis Institutes for Biomedical Research, 4056 Basel, Switzerland.

Celine Be (C)

Novartis Institutes for Biomedical Research, 4056 Basel, Switzerland.

Pascal Mäser (P)

Swiss Tropical and Public Health Institute, Kreuzstrasse 2, 4123 Allschwil, Switzerland.
University of Basel, CH 4000 Basel, Switzerland.

Marcel Kaiser (M)

Swiss Tropical and Public Health Institute, Kreuzstrasse 2, 4123 Allschwil, Switzerland.
University of Basel, CH 4000 Basel, Switzerland.

Ryan Ritchie (R)

University of Glasgow, University Place, Glasgow G12 8TA, U.K.

Michael P Barrett (MP)

University of Glasgow, University Place, Glasgow G12 8TA, U.K.

Thierry T Diagana (TT)

Novartis Institutes for Tropical Diseases, Emeryville, California 94608, United States.

Christopher Sarko (C)

Global Discovery Chemistry, Novartis Institutes for Biomedical Research, Emeryville, California 94608, United States.

Srinivasa P S Rao (SPS)

Novartis Institutes for Tropical Diseases, Emeryville, California 94608, United States.

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Classifications MeSH