Iron deficiency anemia and thrombosis risk in children-revisiting an old hypothesis.
anemia
cerebral sinus venous thrombosis (CVST)
iron deficiency
iron deficiency anemia (IDA)
pediatric thrombosis
Journal
Frontiers in pediatrics
ISSN: 2296-2360
Titre abrégé: Front Pediatr
Pays: Switzerland
ID NLM: 101615492
Informations de publication
Date de publication:
2022
2022
Historique:
received:
23
04
2022
accepted:
11
07
2022
entrez:
18
8
2022
pubmed:
19
8
2022
medline:
19
8
2022
Statut:
epublish
Résumé
Iron deficiency anemia has a high prevalence in children and has repeatedly been implicated as a risk factor for arterial and venous thrombosis. As an effective therapy for iron deficiency anemia is available, understanding the association between this form of anemia and the potentially severe thrombosis phenotype is of major clinical interest. Recent findings shed light on pathophysiology of hypercoagulability resulting from iron-restricted erythropoiesis. Specifically, an animal model of induced iron deficiency allowed identifying multiple mechanisms, by which iron deficiency anemia results in increased thrombus formation and thrombus progression both in arterial and venous thrombosis. These findings complement and support conclusions derived from clinical data. The purpose of this mini review is to summarize current evidence on the association of iron deficiency anemia and thrombosis. We want to increase the awareness of iron deficiency as a risk factor for thrombosis in the pediatric population. We discuss how novel pathophysiological concepts can be translated into the clinical settings and suggest clinical studies on prevention and treatment strategies in high-risk patient groups.
Identifiants
pubmed: 35979407
doi: 10.3389/fped.2022.926925
pmc: PMC9376258
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
926925Informations de copyright
Copyright © 2022 Kalff, Cario and Holzhauer.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
J Child Neurol. 2004 Jul;19(7):526-31
pubmed: 15526958
J Stroke Cerebrovasc Dis. 2019 Nov;28(11):104338
pubmed: 31444045
Nutr Rev. 2011 Nov;69 Suppl 1:S37-42
pubmed: 22043881
Eur J Neurol. 2020 Apr;27(4):716-722
pubmed: 31883169
J Pediatr Hematol Oncol. 2007 Nov;29(11):747-51
pubmed: 17984692
Pediatr Neurol. 1997 Jan;16(1):50-3
pubmed: 9044402
Ophthalmologica. 1996;210(6):358-60
pubmed: 8887395
Ann Hematol. 2002 Nov;81(11):616-21
pubmed: 12454698
Blood. 2014 Jan 30;123(5):615-24
pubmed: 24297872
Ann Hematol. 2014 Apr;93(4):571-6
pubmed: 24141332
Brain. 2005 Mar;128(Pt 3):477-89
pubmed: 15699061
Haematologica. 2021 Mar 01;106(3):782-794
pubmed: 32079699
Pediatrics. 2007 Nov;120(5):1053-7
pubmed: 17974743
Neurol Med Chir (Tokyo). 2006 Dec;46(12):589-93
pubmed: 17185884
Ann Oncol. 2010 May;21 Suppl 5:v244-7
pubmed: 20555090
J Crohns Colitis. 2022 Jun 24;16(5):695-707
pubmed: 34599822
Pol Arch Med Wewn. 2016;126(3):159-65
pubmed: 26942727
J Pediatr. 1990 Sep;117(3):430-2
pubmed: 2167965
Blood. 2019 Jan 3;133(1):30-39
pubmed: 30401704
Echocardiography. 2012 Mar;29(3):369-72
pubmed: 22151052
Br J Haematol. 2020 Sep;190(6):909-915
pubmed: 32342506
Lancet. 1999 Apr 3;353(9159):1167-73
pubmed: 10209995
Lancet Haematol. 2020 Apr;7(4):e342-e350
pubmed: 32220343
Pediatr Blood Cancer. 2012 Aug;59(2):258-64
pubmed: 22038730
Turk Arch Pediatr. 2021 May 01;56(3):236-244
pubmed: 34104915
Scand J Gastroenterol. 1973;8(2):135-8
pubmed: 4697073
PLoS One. 2012;7(4):e34520
pubmed: 22506024
J Child Neurol. 2014 Sep;29(9):NP62-4
pubmed: 24056151
J Clin Neurosci. 2007 Feb;14(2):181-4
pubmed: 17161294
Clin Lab Haematol. 2000 Aug;22(4):221-3
pubmed: 11012634
J Pediatr Neurosci. 2012 Jan;7(1):30-2
pubmed: 22837774
Acta Paediatr. 2010 Nov;99(11):1641-9
pubmed: 20586998
Pediatr Emerg Care. 2010 Nov;26(11):848-51
pubmed: 21057282
J Child Neurol. 2008 Jan;23(1):59-66
pubmed: 18184942
Inflamm Bowel Dis. 2014 May;20(5):936-45
pubmed: 24572205
Blood Rev. 2021 Nov;50:100834
pubmed: 33985796
Arch Dis Child. 2011 Mar;96(3):276-9
pubmed: 21030379
Blood. 2019 Oct 31;134(18):1547-1557
pubmed: 31439541
JAMA. 2022 Jan 11;327(2):129-137
pubmed: 35015038
Handb Clin Neurol. 2020;172:3-31
pubmed: 32768092
J Intern Med. 2020 Feb;287(2):153-170
pubmed: 31665543
Am J Hematol. 2020 Jul 3;:
pubmed: 32619079
Blood. 2012 Nov 8;120(19):3891-7
pubmed: 22948048
Blood Rev. 2017 Jul;31(4):225-233
pubmed: 28216263
Blood Adv. 2018 Nov 27;2(22):3292-3316
pubmed: 30482766
GE Port J Gastroenterol. 2020 Jul;27(4):244-254
pubmed: 32775546
Cureus. 2020 Jun 29;12(6):e8917
pubmed: 32760618
Turk J Med Sci. 2020 Jun 3;50(5):1344-1349
pubmed: 32490645
Inflamm Bowel Dis. 2011 Oct;17(10):2174-83
pubmed: 21910180
J Pediatr Hematol Oncol. 2011 May;33(4):261-4
pubmed: 21516021
J Pediatr Gastroenterol Nutr. 2020 Oct;71(4):563-582
pubmed: 32947565
Stroke. 1990 Mar;21(3):488-93
pubmed: 2309275
Front Pediatr. 2021 Dec 17;9:800461
pubmed: 34976903
Expert Rev Cardiovasc Ther. 2008 Mar;6(3):419-28
pubmed: 18328000
J Coll Physicians Surg Pak. 2018 May;28(5):390-393
pubmed: 29690971
Haematologica. 2021 Mar 01;106(3):661-663
pubmed: 33645945
J Clin Med. 2021 Apr 18;10(8):
pubmed: 33919638
J Neurol. 2021 Sep;268(9):3480-3492
pubmed: 33586004
Neurocrit Care. 2018 Dec;29(3):463-468
pubmed: 29987689
Haematologica. 2020 Aug 13;105(10):2368-2379
pubmed: 33054077
Hematology. 2018 Oct;23(9):664-668
pubmed: 29544395