Pancreatic Cancer and the Obesity Epidemic: A Narrative Review.
chronic pancreatitis
diabetes mellitus type 2
malignant pancreatic cancer
obesity-related illnesses
type b insulin resistance
Journal
Cureus
ISSN: 2168-8184
Titre abrégé: Cureus
Pays: United States
ID NLM: 101596737
Informations de publication
Date de publication:
Jul 2022
Jul 2022
Historique:
accepted:
07
07
2022
entrez:
12
8
2022
pubmed:
13
8
2022
medline:
13
8
2022
Statut:
epublish
Résumé
Pancreatic cancer (PC) is one of the most frequent causes of death. It usually affects older individuals with incidence closely approaching mortality due to its early asymptomatic feature and highly metastatic nature. Multiple risk factors such as family history, smoking, and germline mutations are associated with PC development, with obesity being one of the controllable factors. This review article focuses on the compilation of various studies to help establish a correlation between obesity or an increased body mass index and PC development. Hence, in this review, we have summarised multiple biological mechanisms of PC development induced by obesity, including insulin resistance, inflammation, beta-cell dysfunction, and oxidative stress, to prove that their correlation when combined with other factors, such as smoking, alcohol and chronic pancreatitis, may increase its risk. We have also reviewed potential diagnostic and screening techniques, such as evaluating precancerous lesions in high-risk patients and management plans discussing upcoming advances in treatment tactics such as neoadjuvant therapy, to reduce post-operative complications.
Identifiants
pubmed: 35959181
doi: 10.7759/cureus.26654
pmc: PMC9360631
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
e26654Informations de copyright
Copyright © 2022, Poman et al.
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
Références
Diabetes. 2004 May;53(5):1215-21
pubmed: 15111489
Int J Obes Relat Metab Disord. 2002 Nov;26(11):1407-33
pubmed: 12439643
Cancer Res. 2009 Aug 15;69(16):6539-45
pubmed: 19679549
BMC Cancer. 2014 Sep 29;14:728
pubmed: 25266049
Cancer Epidemiol Biomarkers Prev. 2005 Dec;14(12):2829-39
pubmed: 16364997
Eur J Surg. 1993 Feb;159(2):101-7
pubmed: 8098623
J Clin Invest. 1996 Jun 15;97(12):2859-65
pubmed: 8675698
Int J Cancer. 2015 Mar 1;136(5):E359-86
pubmed: 25220842
J Gastrointest Surg. 2019 Apr;23(4):768-778
pubmed: 30706376
J Epidemiol Community Health. 2017 Nov;71(11):1059-1067
pubmed: 28900029
N Engl J Med. 2013 Nov 21;369(21):2001-11
pubmed: 24256379
Arch Intern Med. 2010 May 10;170(9):791-802
pubmed: 20458087
Prog Lipid Res. 2006 Jan;45(1):42-72
pubmed: 16445986
J Surg Res. 2010 May 1;160(1):90-101
pubmed: 19560785
BMC Cancer. 2013 Jul 08;13:337
pubmed: 23835106
Clin Chim Acta. 2007 May 1;380(1-2):24-30
pubmed: 17343838
Diabetes. 2002 Jun;51(6):1884-8
pubmed: 12031977
J Clin Endocrinol Metab. 2007 Apr;92(4):1510-6
pubmed: 17213279
Am J Clin Nutr. 2013 Oct;98(4):1057-65
pubmed: 23985810
Cancer Res. 2012 Dec 1;72(23):6257-67
pubmed: 23041548
J Clin Endocrinol Metab. 2001 Sep;86(9):4047-58
pubmed: 11549624
Cancer Epidemiol Biomarkers Prev. 2005 Feb;14(2):459-66
pubmed: 15734973
Arch Physiol Biochem. 2009 May;115(2):86-96
pubmed: 19485704
Eur J Cancer. 2011 Sep;47(13):1928-37
pubmed: 21458985
Obes Surg. 2015 Aug;25(8):1544-6
pubmed: 26072171
Pancreas. 2013 Mar;42(2):198-201
pubmed: 23000893
Ann Intern Med. 2005 Mar 15;142(6):403-11
pubmed: 15767618
Gastroenterology. 2001 Apr;120(5):1263-70
pubmed: 11266389
Diabetes Obes Metab. 2011 Dec;13(12):1063-72
pubmed: 21733057
Nat Rev Dis Primers. 2016 Apr 21;2:16022
pubmed: 27158978
Clin Sci (Lond). 2009 Nov 23;118(5):315-32
pubmed: 19922415
Diabetes. 1993 Nov;42(11):1663-72
pubmed: 8405710
J Clin Invest. 2006 Jul;116(7):1784-92
pubmed: 16823476
Lancet. 2020 Jun 27;395(10242):2008-2020
pubmed: 32593337
Int J Clin Oncol. 2021 Oct;26(10):1784-1792
pubmed: 34476650
Am J Clin Nutr. 2015 Apr 29;101(6):1320S-1329S
pubmed: 25926512
Cancer Res. 2014 Jun 1;74(11):2913-21
pubmed: 24840647
Diabetes. 1976 Jun;25(6):494-504
pubmed: 1278601
J Exp Clin Cancer Res. 2021 Apr 15;40(1):133
pubmed: 33858491
JAMA. 2009 Jun 24;301(24):2553-62
pubmed: 19549972
Prim Care Diabetes. 2019 Jun;13(3):276-282
pubmed: 30553699
Clin Gastroenterol Hepatol. 2009 Nov;7(11 Suppl):S48-54
pubmed: 19896099
G Ital Cardiol. 1985 Oct;15(10):1002-3
pubmed: 3912254
Curr Pharm Des. 2011;17(8):805-12
pubmed: 21443483
Pancreas. 2000 Oct;21(3):310-20
pubmed: 11039477
Asian Pac J Cancer Prev. 2015;16(14):5619-24
pubmed: 26320426
Mol Cancer Ther. 2010 May;9(5):1092-9
pubmed: 20442309
CA Cancer J Clin. 2016 Jan-Feb;66(1):7-30
pubmed: 26742998
Arterioscler Thromb Vasc Biol. 2003 Mar 1;23(3):434-9
pubmed: 12615693
Rev Epidemiol Sante Publique. 1992;40(6):447-53
pubmed: 1287744
Diabetol Metab Syndr. 2011 Jun 13;3(1):10
pubmed: 21668983
PLoS One. 2014 Jan 08;9(1):e85133
pubmed: 24416351
J Clin Invest. 2006 Jul;116(7):1793-801
pubmed: 16823477
Nat Rev Cancer. 2004 Jul;4(7):505-18
pubmed: 15229476
Metabolism. 2019 Mar;92:121-135
pubmed: 30445141
J Thorac Dis. 2017 Mar;9(3):448-451
pubmed: 28449441
Cochrane Database Syst Rev. 2006 Oct 18;(4):CD003817
pubmed: 17054187
Mol Carcinog. 2012 Jan;51(1):53-63
pubmed: 22162231
Dig Dis. 2011;29(2):235-42
pubmed: 21734390
Biochem J. 2000 Jun 15;348 Pt 3:607-14
pubmed: 10839993
J Clin Invest. 2005 May;115(5):1111-9
pubmed: 15864338
Diabetologia. 2010 May;53(5):866-74
pubmed: 20143044
Exp Clin Endocrinol Diabetes. 2010 Jan;118(1):4-8
pubmed: 20127570
Cancer Causes Control. 2013 Jan;24(1):13-25
pubmed: 23112111
Lancet Gastroenterol Hepatol. 2019 Dec;4(12):934-947
pubmed: 31648972
Br J Cancer. 2013 Nov 26;109(11):2911-6
pubmed: 24149179
World J Gastrointest Oncol. 2018 Aug 15;10(8):202-210
pubmed: 30147846
World J Gastroenterol. 2008 Dec 21;14(47):7192-8
pubmed: 19084933
Acta Pharm Sin B. 2020 Mar;10(3):399-413
pubmed: 32140388
Lancet Public Health. 2019 Mar;4(3):e137-e147
pubmed: 30733056
Clin Cancer Res. 2015 Aug 1;21(15):3522-8
pubmed: 25700304
J Hepatol. 2009 Oct;51(4):765-77
pubmed: 19664840
N Engl J Med. 2017 Sep 21;377(12):1143-1155
pubmed: 28930514
World J Gastroenterol. 2016 Nov 28;22(44):9694-9705
pubmed: 27956793
N Engl J Med. 1996 Feb 1;334(5):292-5
pubmed: 8532024
Ann Oncol. 2012 Apr;23(4):843-52
pubmed: 21890910
J Biol Chem. 1991 Oct 5;266(28):18868-76
pubmed: 1717456
Endocrinology. 2004 May;145(5):2273-82
pubmed: 14726444
J Clin Invest. 2004 Dec;114(12):1752-61
pubmed: 15599400
Breast Cancer Res. 2007;9(1):201
pubmed: 17224037
Diabetes. 2006 Jun;55(6):1537-45
pubmed: 16731815