Evaluation of the Binding Relationship of the RdRp Enzyme to Novel Thiazole/Acid Hydrazone Hybrids Obtainable through Green Synthetic Procedure.
RdRp enzyme
acid hydrazide
docking
grinding
hydrazones
pyrazoles
Journal
Polymers
ISSN: 2073-4360
Titre abrégé: Polymers (Basel)
Pays: Switzerland
ID NLM: 101545357
Informations de publication
Date de publication:
03 Aug 2022
03 Aug 2022
Historique:
received:
10
06
2022
revised:
17
07
2022
accepted:
21
07
2022
entrez:
12
8
2022
pubmed:
13
8
2022
medline:
13
8
2022
Statut:
epublish
Résumé
The viral RNA-dependent RNA polymerase (RdRp) complex is used by SARS-CoV-2 for genome replication and transcription, making RdRp an interesting target for developing the antiviral treatment. Hence the current work is concerned with the green synthesis, characterization and docking study with the RdRp enzyme of the series of novel and diverse hydrazones and pyrazoles. 4-Methyl-2-(2-(1-phenylethylidene)hydrazineyl)thiazole-5-carbohydrazide was prepared and then condensed with different carbonyl compounds (aldehydes and ketones either carbocyclic aromatic or heterocyclic) afforded the corresponding hydrazide-hydrazones. The combination of the acid hydrazide with bifunctional reagents such as acetylacetone,
Identifiants
pubmed: 35956675
pii: polym14153160
doi: 10.3390/polym14153160
pmc: PMC9371204
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Princess Nourah bint Abdulrahman University
ID : PNURSP2022R24
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