Arctostaphylos uva-ursi L. leaves extract and its modified cysteine preparation for the management of insulin resistance: chemical analysis and bioactivity.
Arctostaphylos uva-ursi L.
Extract
Hypoglycaemic activity
Leaves
Phenolic substances
Journal
Natural products and bioprospecting
ISSN: 2192-2195
Titre abrégé: Nat Prod Bioprospect
Pays: Germany
ID NLM: 101577734
Informations de publication
Date de publication:
12 Aug 2022
12 Aug 2022
Historique:
received:
11
04
2022
accepted:
12
06
2022
entrez:
11
8
2022
pubmed:
12
8
2022
medline:
12
8
2022
Statut:
epublish
Résumé
Bearberry (Arctostaphylos uva-ursi L.) is a perennial plant of the heather family (Ericaceae). The leaves are dominated by arbutin, phenol carbonic acids flavonoids, saponins, etc. It was previously shown that the bearberry leaves extract reduced blood glucose level in healthy animals under glucose overload, so it need to be studied more detail. The aim of the study was to investigate the chemical composition and the effect of dry alcohol extract from bearberry leaves, which enriched with cysteine, on the rats pancreas under experimental dexamethasone-induced insulin resistance (IR). Arctostaphylos uva-ursi L. leaves extract and its modified cysteine preparation were obtained according to the developed method with 50% ethanol solution. Their phytochemical profile, hypoglycaemic and pancreatic protective effect were investigated. Phenologlycoside (arbutin), phenolic carboxylic acid (gallic acid), 5 flavonoids and 4 hydroxycinnamic acids were identified and quantified in the extracts by HPLC. Present data revealed that bearberry leaves alcoholic dry extract enriched with cysteine has a hypoglycaemic and pancreatic protective effect in treated animals under dexamethasone-induced IR model. Treatment improved hyperglycaemia, insulin resistance and beta cell reduction induced by dexamethasone injections.
Identifiants
pubmed: 35953755
doi: 10.1007/s13659-022-00352-1
pii: 10.1007/s13659-022-00352-1
pmc: PMC9372252
doi:
Types de publication
Journal Article
Langues
eng
Pagination
30Informations de copyright
© 2022. The Author(s).
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