CRISPR/Cas9 genome editing to create nonhuman primate models for studying stem cell therapies for HIV infection.
CCR5
CRISPR/Cas9
HIV
HSC transplantation
Nonhuman primates
Pluripotent stem cells
SIV
Journal
Retrovirology
ISSN: 1742-4690
Titre abrégé: Retrovirology
Pays: England
ID NLM: 101216893
Informations de publication
Date de publication:
10 08 2022
10 08 2022
Historique:
received:
21
01
2022
accepted:
28
07
2022
entrez:
10
8
2022
pubmed:
11
8
2022
medline:
13
8
2022
Statut:
epublish
Résumé
Nonhuman primates (NHPs) are well-established basic and translational research models for human immunodeficiency virus (HIV) infections and pathophysiology, hematopoietic stem cell (HSC) transplantation, and assisted reproductive technologies. Recent advances in CRISPR/Cas9 gene editing technologies present opportunities to refine NHP HIV models for investigating genetic factors that affect HIV replication and designing cellular therapies that exploit genetic barriers to HIV infections, including engineering mutations into CCR5 and conferring resistance to HIV/simian immunodeficiency virus (SIV) infections. In this report, we provide an overview of recent advances and challenges in gene editing NHP embryos and discuss the value of genetically engineered animal models for developing novel stem cell-based therapies for curing HIV.
Identifiants
pubmed: 35948929
doi: 10.1186/s12977-022-00604-5
pii: 10.1186/s12977-022-00604-5
pmc: PMC9363854
doi:
Types de publication
Journal Article
Review
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
17Subventions
Organisme : NIH HHS
ID : P51 OD011106
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL132891
Pays : United States
Organisme : NIH HHS
ID : R24 OD021322
Pays : United States
Organisme : NICHD NIH HHS
ID : K99 HD099154
Pays : United States
Informations de copyright
© 2022. The Author(s).
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