Chemical Composition, Antiaging Activities and Molecular Docking Studies of Essential Oils from Acca sellowiana (Feijoa).
Acetylcholinesterase
Acyclic Monoterpenes
Amyloid Precursor Protein Secretases
Feijoa
/ chemistry
Molecular Docking Simulation
Monocyclic Sesquiterpenes
Monophenol Monooxygenase
/ analysis
Oils, Volatile
/ chemistry
Oxides
Pancreatic Elastase
/ analysis
Plant Leaves
/ chemistry
Polycyclic Sesquiterpenes
Sesquiterpenes
Terpenes
Acca sellowiana
anti-Alzheimer
antiaging
caryophyllene oxide
essential oils
Journal
Chemistry & biodiversity
ISSN: 1612-1880
Titre abrégé: Chem Biodivers
Pays: Switzerland
ID NLM: 101197449
Informations de publication
Date de publication:
Sep 2022
Sep 2022
Historique:
received:
26
03
2022
accepted:
04
08
2022
pubmed:
9
8
2022
medline:
20
9
2022
entrez:
8
8
2022
Statut:
ppublish
Résumé
This study aimed to investigate the chemical composition of essential oils isolated from Acca sellowiana (feijoa) leaves and stems and elaborate on their relevance as natural anti-aging, coupled with molecular-docking studies. The isolated oils were analysed using gas chromatography-mass spectrometry analysis and investigated for inhibitory effects against acetylcholinesterase, β-secretase, collagenase, elastase and tyrosinase. Molecular-modelling study was performed using MOE-Dock program to evaluate binding interactions of major components with the above-mentioned targets. The leaf oil revealed the predominance of caryophyllene oxide (24.3 %), linalool (7.9 %), and spathulenol (6.6 %), while the stem oil was presented by caryophyllene oxide (38.1 %), α-zingiberene (10.1 %) and humulene oxide II (6.0 %). The stem oil expressed superior inhibitory activities against acetylcholinesterase (IC
Identifiants
pubmed: 35938449
doi: 10.1002/cbdv.202200272
doi:
Substances chimiques
Acyclic Monoterpenes
0
Monocyclic Sesquiterpenes
0
Oils, Volatile
0
Oxides
0
Polycyclic Sesquiterpenes
0
Sesquiterpenes
0
Terpenes
0
cadinol
0
spathulenol
7XV9L96SJJ
zingiberene
8XOC63EI5F
linalool
D81QY6I88E
Monophenol Monooxygenase
EC 1.14.18.1
Acetylcholinesterase
EC 3.1.1.7
Amyloid Precursor Protein Secretases
EC 3.4.-
Pancreatic Elastase
EC 3.4.21.36
caryophyllene oxide
S2XU9K448U
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e202200272Subventions
Organisme : Deanship of Scientific Research at King Khalid University
ID : R.G.P.2/233/43
Informations de copyright
© 2022 Wiley-VHCA AG, Zurich, Switzerland.
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