Non-clinical studies indicating lack of interactions between iron/calcium ions and linzagolix, an orally available GnRH antagonist.

Animals Calcium Carboxylic Acids Female Gonadotropin-Releasing Hormone Humans Ions Iron Pyrimidines Rats Solubility
ADME DDI GnRH antagonist Linzagolix calcium ion iron ion

Journal

Xenobiotica; the fate of foreign compounds in biological systems
ISSN: 1366-5928
Titre abrégé: Xenobiotica
Pays: England
ID NLM: 1306665

Informations de publication

Date de publication:
May 2022
Historique:
pubmed: 2 8 2022
medline: 31 8 2022
entrez: 1 8 2022
Statut: ppublish

Résumé

Linzagolix is an orally available gonadotropin-releasing hormone antagonist used to treat sex-hormone-dependent diseases in women. This study aimed to investigate drug-drug interactions between linzagolix and iron/calcium ions in the intended clinical setting by conducting pharmacokinetic studies

Identifiants

DOI: 10.1080/00498254.2022.2109076 PMID: 35913106
pubmed: 35913106
doi: 10.1080/00498254.2022.2109076
doi:

Substances chimiques

Carboxylic Acids 0
Ions 0
Pyrimidines 0
Gonadotropin-Releasing Hormone 33515-09-2
linzagolix 7CDW97HUEX
Iron E1UOL152H7
Calcium SY7Q814VUP

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

488-497

Auteurs

Kaoru Kobayashi (K)

Central Research Laboratories, Kissei Pharmaceutical Co., Ltd, Azumino, Japan.

Motohiro Tezuka (M)

Central Research Laboratories, Kissei Pharmaceutical Co., Ltd, Azumino, Japan.

Yasuyuki Toyoda (Y)

Central Research Laboratories, Kissei Pharmaceutical Co., Ltd, Azumino, Japan.

Takao Kurooka (T)

Toxicological Laboratories, Kissei Pharmaceutical Co., Ltd., Azumino, Japan.

Emiko Oota (E)

Central Research Laboratories, Kissei Pharmaceutical Co., Ltd, Azumino, Japan.

Yasuaki Tamai (Y)

Central Research Laboratories, Kissei Pharmaceutical Co., Ltd, Azumino, Japan.

Yoshikazu Abe (Y)

Central Research Laboratories, Kissei Pharmaceutical Co., Ltd, Azumino, Japan.

Sumiyoshi Kiguchi (S)

Central Research Laboratories, Kissei Pharmaceutical Co., Ltd, Azumino, Japan.

Takuro Endo (T)

Central Research Laboratories, Kissei Pharmaceutical Co., Ltd, Azumino, Japan.

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Classifications MeSH

Recherchemedicale.com › Eucaryotes › Animaux › Non-clinical studies indicating lack of...
Recherchemedicale.com › Facteurs biologiques › Facteurs de la coagulation sanguine › Calcium › Non-clinical studies indicating lack of...
Recherchemedicale.com › Composés chimiques organiques › Acides carboxyliques › Non-clinical studies indicating lack of...
Recherchemedicale.com › Acides aminés, peptides et protéines › Protéines › Protéines de tissu nerveux › Neuropeptides › Hormones hypothalamiques › Hormones hypophysiotropes libératrices › Hormone de libération des gonadotrophines › Non-clinical studies indicating lack of...
Recherchemedicale.com › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Non-clinical studies indicating lack of...
Recherchemedicale.com › Produits chimiques inorganiques › Électrolytes › Ions › Non-clinical studies indicating lack of...
Recherchemedicale.com › Produits chimiques inorganiques › Métaux › Métaux lourds › Fer › Non-clinical studies indicating lack of...
Recherchemedicale.com › Composés hétérocycliques › Composés hétéromonocycliques › Pyrimidines › Non-clinical studies indicating lack of...
Recherchemedicale.com › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Non-clinical studies indicating lack of...
Recherchemedicale.com › Phénomènes chimiques › Solubilité › Non-clinical studies indicating lack of...