Clinical and Molecular Characterization of a Rare Case of BNT162b2 mRNA COVID-19 Vaccine-Associated Myositis.

BNT162b2 COVID-19 mRNA vaccine myositis

Journal

Vaccines
ISSN: 2076-393X
Titre abrégé: Vaccines (Basel)
Pays: Switzerland
ID NLM: 101629355

Informations de publication

Date de publication:
16 Jul 2022
Historique:
received: 18 06 2022
revised: 12 07 2022
accepted: 13 07 2022
entrez: 27 7 2022
pubmed: 28 7 2022
medline: 28 7 2022
Statut: epublish

Résumé

Initial clinical trials and surveillance data have shown that the most commonly administered BNT162b2 COVID-19 mRNA vaccine is effective and safe. However, several cases of mRNA vaccine-induced mild to moderate adverse events were recently reported. Here, we report a rare case of myositis after injection of the first dose of BNT162b2 COVID-19 mRNA vaccine into the left deltoid muscle of a 34-year-old, previously healthy woman who presented progressive proximal muscle weakness, progressive dysphagia, and dyspnea with respiratory failure. One month after vaccination, BNT162b2 vaccine mRNA expression was detected in a tissue biopsy of the right deltoid and quadriceps muscles. We propose this case as a rare example of COVID-19 mRNA vaccine-induced myositis. This study comprehensively characterizes the clinical and molecular features of BNT162b2 mRNA vaccine-associated myositis in which the patient was severely affected.

Identifiants

pubmed: 35891299
pii: vaccines10071135
doi: 10.3390/vaccines10071135
pmc: PMC9324661
pii:
doi:

Types de publication

Case Reports

Langues

eng

Références

FEBS Open Bio. 2022 Jan;12(1):106-117
pubmed: 34608759
ACS Nano. 2021 Jun 28;:
pubmed: 34181394
Neurol Int. 2022 Apr 27;14(2):406-416
pubmed: 35645352
Vaccines (Basel). 2020 Jun 09;8(2):
pubmed: 32526960
Int J Biol Macromol. 2022 Apr 15;204:161-168
pubmed: 35074332
J Korean Med Sci. 2022 Feb 07;37(5):e32
pubmed: 35132838
Front Immunol. 2021 Sep 30;12:762006
pubmed: 34659268
Vaccine. 2021 Jun 29;39(29):3790-3793
pubmed: 34092429
Cureus. 2021 Oct 23;13(10):e18985
pubmed: 34820240
Eur Heart J. 2022 Jan 28;:
pubmed: 35090032
Rev Esp Cardiol (Engl Ed). 2022 Jul;75(7):614-616
pubmed: 35277352
Nano Today. 2022 Apr;43:101403
pubmed: 35079274
Nature. 2022 Jul;607(7917):18-19
pubmed: 35760853
Allergo J Int. 2021;30(2):51-55
pubmed: 33643776
Nucleic Acids Res. 2021 Jan 8;49(D1):D1113-D1121
pubmed: 33166390
Neuromuscul Disord. 2022 Mar;32(3):230-235
pubmed: 35227552
Proc Natl Acad Sci U S A. 2020 Nov 3;117(44):27456-27464
pubmed: 33051302
N Engl J Med. 2021 Dec 2;385(23):2140-2149
pubmed: 34614328
Int Immunopharmacol. 2021 Oct;99:107970
pubmed: 34280851
Vaccines (Basel). 2021 Jul 03;9(7):
pubmed: 34358150
Nature. 2020 Oct;586(7830):594-599
pubmed: 32998157
Hum Vaccin Immunother. 2021 Dec 2;17(12):5013-5015
pubmed: 34715003
Rheumatol Int. 2021 Mar;41(3):509-518
pubmed: 33515320
J Autoimmun. 2022 Jun;130:102830
pubmed: 35461018
BMJ. 2020 Dec 11;371:m4799
pubmed: 33310748
Vaccines (Basel). 2021 Aug 31;9(9):
pubmed: 34579211
J Prim Care Community Health. 2021 Jan-Dec;12:21501327211051933
pubmed: 34709075
Science. 2022 Jul 5;:eabq0839
pubmed: 35857620
Front Med (Lausanne). 2021 Sep 30;8:751598
pubmed: 34660652
Vaccines (Basel). 2022 Jun 06;10(6):
pubmed: 35746508
Muscle Nerve. 2020 Sep;62(3):E57-E60
pubmed: 32535934
J Neurol Sci. 2022 May 15;436:120225
pubmed: 35290838
Vaccines (Basel). 2022 Jun 11;10(6):
pubmed: 35746543
Ann Intern Med. 2021 Feb;174(2):JC15
pubmed: 33524290
Ann Rheum Dis. 2021 Oct;80(10):1330-1338
pubmed: 34127481
Signal Transduct Target Ther. 2022 Mar 23;7(1):94
pubmed: 35322018
Cleve Clin J Med. 2021 Dec 2;88(12):648-650
pubmed: 34857596
N Engl J Med. 2021 Feb 4;384(5):403-416
pubmed: 33378609
Nature. 2022 Jan;601(7894):617-622
pubmed: 34814158
J Med Case Rep. 2022 Jan 30;16(1):57
pubmed: 35094715
Nat Methods. 2012 Mar 04;9(4):357-9
pubmed: 22388286
N Engl J Med. 2021 Sep 16;385(12):1078-1090
pubmed: 34432976
QJM. 2021 Oct 7;114(6):424-425
pubmed: 33647971
J Neurol. 2022 Aug;269(8):3965-3981
pubmed: 35503373
J Travel Med. 2021 Oct 11;28(7):
pubmed: 34128049
JAMA Neurol. 2021 Nov 1;78(11):1409-1411
pubmed: 34468703
J Neurol Sci. 2022 Mar 15;434:120102
pubmed: 34953348
Curr Rheumatol Rep. 2021 Jul 3;23(8):63
pubmed: 34216297
JAMA. 2022 Apr 26;327(16):1611-1612
pubmed: 35297962
Neurol Sci. 2022 Mar;43(3):1491-1493
pubmed: 34981285
RNA. 2014 Oct;20(10):1645-52
pubmed: 25161313
IDCases. 2021;25:e01245
pubmed: 34381692
Neurol Sci. 2021 Nov;42(11):4401-4402
pubmed: 34346014
Am J Hematol. 2021 May 1;96(5):534-537
pubmed: 33606296
Diabetes Metab Syndr. 2021 Jul-Aug;15(4):102170
pubmed: 34186348
JAMA Netw Open. 2021 Aug 2;4(8):e2122255
pubmed: 34463744
J Infect Chemother. 2022 Apr;28(4):576-581
pubmed: 35058126
Elife. 2018 Sep 07;7:
pubmed: 30192227
QJM. 2022 May 10;115(5):331-333
pubmed: 35426946
N Engl J Med. 2020 Dec 31;383(27):2603-2615
pubmed: 33301246
Brief Bioinform. 2013 Mar;14(2):178-92
pubmed: 22517427
J Korean Med Sci. 2022 Mar 21;37(11):e91
pubmed: 35315602

Auteurs

Eli Magen (E)

Medicine C Department, Clinical Immunology and Allergy Division, Barzilai University Medical Center, Ben-Gurion University of the Negev, Ashkelon 7830604, Israel.
Leumit Health Services, Tel Aviv 6473817, Israel.

Sumit Mukherjee (S)

Azrieli Faculty of Medicine, Bar-Ilan University, Safed 1311502, Israel.
Department of Computer Science, Ben-Gurion University, Beer-Sheva 8410501, Israel.

Mahua Bhattacharya (M)

Azrieli Faculty of Medicine, Bar-Ilan University, Safed 1311502, Israel.

Rajesh Detroja (R)

Azrieli Faculty of Medicine, Bar-Ilan University, Safed 1311502, Israel.

Eugene Merzon (E)

Leumit Health Services, Tel Aviv 6473817, Israel.
Department of Family Medicine, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel.

Idan Blum (I)

Medicine C Department, Clinical Immunology and Allergy Division, Barzilai University Medical Center, Ben-Gurion University of the Negev, Ashkelon 7830604, Israel.

Alejandro Livoff (A)

Pathology Department, Barzilai University Medical Center, Ashkelon 7830604, Israel.

Mark Shlapobersky (M)

Pathology Department, Barzilai University Medical Center, Ashkelon 7830604, Israel.

Gideon Baum (G)

Azrieli Faculty of Medicine, Bar-Ilan University, Safed 1311502, Israel.

Ran Talisman (R)

Plastic Surgery Department, Barzilai University Medical Center, Ashkelon 7830604, Israel.

Evgenia Cherniavsky (E)

Imaging Department, Barzilai University Medical Center, Ashkelon 7830604, Israel.

Amir Dori (A)

Department of Neurology, Sheba Medical Center, Ramat Gan 5262000, Israel.
Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel.

Milana Frenkel-Morgenstern (M)

Azrieli Faculty of Medicine, Bar-Ilan University, Safed 1311502, Israel.

Classifications MeSH