Synthesis and Evaluation of Anti-HIV Activity of Mono- and Di-Substituted Phosphonamidate Conjugates of Tenofovir.
anti-HIV activity
ester conjugates of TFV
phosphonamidate
tenofovir (TFV)
tenofovir alafenamide (TAF)
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
12 Jul 2022
12 Jul 2022
Historique:
received:
05
05
2022
revised:
04
07
2022
accepted:
05
07
2022
entrez:
27
7
2022
pubmed:
28
7
2022
medline:
29
7
2022
Statut:
epublish
Résumé
The activity of nucleoside and nucleotide analogs as antiviral agents requires phosphorylation by endogenous enzymes. Phosphate-substituted analogs have low bioavailability due to the presence of ionizable negatively-charged groups. To circumvent these limitations, several prodrug approaches have been proposed. Herein, we hypothesized that the conjugation or combination of the lipophilic amide bond with nucleotide-based tenofovir (TFV) (
Identifiants
pubmed: 35889320
pii: molecules27144447
doi: 10.3390/molecules27144447
pmc: PMC9316519
pii:
doi:
Substances chimiques
Amides
0
Anti-HIV Agents
0
Esters
0
Naphthols
0
Nucleotides
0
Oleic Acid
2UMI9U37CP
Tenofovir
99YXE507IL
Alanine
OF5P57N2ZX
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Chapman University School of Pharmacy
ID : NA
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