Mean Platelet Volume in the Diagnosis of Acute Appendicitis in the Pediatric Population: A Systematic Review and Meta-Analysis.
acute appendicitis
biomarker
children
mean platelet volume
non-specific abdominal pain
Journal
Diagnostics (Basel, Switzerland)
ISSN: 2075-4418
Titre abrégé: Diagnostics (Basel)
Pays: Switzerland
ID NLM: 101658402
Informations de publication
Date de publication:
30 Jun 2022
30 Jun 2022
Historique:
received:
07
06
2022
revised:
26
06
2022
accepted:
28
06
2022
entrez:
27
7
2022
pubmed:
28
7
2022
medline:
28
7
2022
Statut:
epublish
Résumé
Mean Platelet Volume (MPV) has been suggested as a biomarker for acute appendicitis (AA) in the adult population. The utility of MPV in pediatric AA remains vague. This systematic review and meta-analysis aimed to systematically summarize and compare all relevant data on MPV as a diagnostic biomarker for AA in children. Databases were systematically searched using keywords ((mean platelet volume) OR mpv) AND (appendicitis). The inclusion criteria were all comparative studies of MPV in children aged less than 18 years and diagnosed with AA. Two authors independently assessed the methodological quality using the Downs and Black scale. We included fourteen studies in the final meta-analysis; most were retrospective. Eight studies compared the MPV values between AA and non-AA; four studies compared the same between AA and healthy controls; two studies compared the MPV values among all three groups. The estimated heterogeneity among the studies for all outcomes was high and statistically significant. The pooling the data showed no statistically significant difference in MPV (weighted mean difference (WMD) = -0.42, 95% CI = (-1.04, 0.20), While MPV levels seem to have some utility in adult AA diagnosis, MPV levels should not dictate treatment options in pediatric AA.
Sections du résumé
BACKGROUND
BACKGROUND
Mean Platelet Volume (MPV) has been suggested as a biomarker for acute appendicitis (AA) in the adult population. The utility of MPV in pediatric AA remains vague. This systematic review and meta-analysis aimed to systematically summarize and compare all relevant data on MPV as a diagnostic biomarker for AA in children.
METHODS
METHODS
Databases were systematically searched using keywords ((mean platelet volume) OR mpv) AND (appendicitis). The inclusion criteria were all comparative studies of MPV in children aged less than 18 years and diagnosed with AA. Two authors independently assessed the methodological quality using the Downs and Black scale.
RESULTS
RESULTS
We included fourteen studies in the final meta-analysis; most were retrospective. Eight studies compared the MPV values between AA and non-AA; four studies compared the same between AA and healthy controls; two studies compared the MPV values among all three groups. The estimated heterogeneity among the studies for all outcomes was high and statistically significant. The pooling the data showed no statistically significant difference in MPV (weighted mean difference (WMD) = -0.42, 95% CI = (-1.04, 0.20),
CONCLUSION
CONCLUSIONS
While MPV levels seem to have some utility in adult AA diagnosis, MPV levels should not dictate treatment options in pediatric AA.
Identifiants
pubmed: 35885500
pii: diagnostics12071596
doi: 10.3390/diagnostics12071596
pmc: PMC9318144
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Références
Emerg Med Int. 2012;2012:823095
pubmed: 22970376
Pediatr Emerg Care. 2000 Jun;16(3):160-2
pubmed: 10888451
Updates Surg. 2022 Jun;74(3):1169-1170
pubmed: 33528798
BMC Pediatr. 2020 Apr 6;20(1):151
pubmed: 32248803
Eur Rev Med Pharmacol Sci. 2021 Dec;25(23):7346-7353
pubmed: 34919234
Emerg Med Int. 2019 Sep 19;2019:4608053
pubmed: 31641539
Diagnostics (Basel). 2022 Apr 17;12(4):
pubmed: 35454059
J Int Med Res. 2020 Sep;48(9):300060520946515
pubmed: 32962484
Acad Emerg Med. 2017 May;24(5):523-551
pubmed: 28214369
J Pak Med Assoc. 2019 May;69(5):647-654
pubmed: 31926114
JAMA. 2018 Sep 25;320(12):1259-1265
pubmed: 30264120
J Epidemiol Community Health. 1998 Jun;52(6):377-84
pubmed: 9764259
J Immunol Res. 2020 Sep 01;2020:2670527
pubmed: 32953890
Updates Surg. 2021 Aug;73(4):1327-1341
pubmed: 33439467
Am J Emerg Med. 2019 Mar;37(3):411-414
pubmed: 29866415
Ann Clin Lab Sci. 2017 Nov;47(6):768-772
pubmed: 29263055
Pediatr Surg Int. 2021 Jul;37(7):843-849
pubmed: 33677613
Surgery. 2010 Mar;147(3):366-72
pubmed: 19892382
Turk J Pediatr. 2018;60(2):173-179
pubmed: 30325124
BJS Open. 2021 Jan 8;5(1):
pubmed: 33609379
J Coll Physicians Surg Pak. 2020 Apr;30(4):420-424
pubmed: 32513365
Wien Med Wochenschr. 2022 Jan 10;:
pubmed: 35006517
Afr Health Sci. 2011 Sep;11(3):427-32
pubmed: 22275934
Ulus Travma Acil Cerrahi Derg. 2017 Jul;23(4):317-321
pubmed: 28762455
Br J Surg. 2022 May 16;109(6):503-509
pubmed: 35576384
Clin Exp Immunol. 2006 Jan;143(1):117-24
pubmed: 16367942
Abdom Radiol (NY). 2021 Mar;46(3):948-959
pubmed: 32914350
Int J Clin Exp Med. 2015 Jan 15;8(1):1291-5
pubmed: 25785128
Eur J Pediatr Surg. 2020 Aug;30(4):350-356
pubmed: 31022754
BMC Pediatr. 2021 Jun 8;21(1):268
pubmed: 34103023
BMJ. 2009 Jul 21;339:b2535
pubmed: 19622551
Arch Argent Pediatr. 2019 Dec 1;117(6):375-380
pubmed: 31758879
Cochrane Database Syst Rev. 2021 Dec 14;12:CD012028
pubmed: 34905621
Ann Med Surg (Lond). 2021 May 27;66:102448
pubmed: 34136215
JAMA. 2020 Aug 11;324(6):581-593
pubmed: 32730561
Pediatr Emerg Care. 2022 Feb 1;38(2):e739-e742
pubmed: 35100771
Biometrics. 1977 Mar;33(1):159-74
pubmed: 843571
Ann Surg. 2007 Jun;245(6):886-92
pubmed: 17522514
PLoS One. 2019 Jul 25;14(7):e0220202
pubmed: 31344073