Accelerated aging with HIV begins at the time of initial HIV infection.

Epigenetics Human physiology Immunology Virology

Journal

iScience
ISSN: 2589-0042
Titre abrégé: iScience
Pays: United States
ID NLM: 101724038

Informations de publication

Date de publication:
15 Jul 2022
Historique:
received: 23 06 2021
revised: 06 12 2021
accepted: 23 05 2022
entrez: 26 7 2022
pubmed: 27 7 2022
medline: 27 7 2022
Statut: epublish

Résumé

Living with HIV infection is associated with early onset of aging-related chronic conditions, sometimes described as accelerated aging. Epigenetic DNA methylation patterns can evaluate acceleration of biological age relative to chronological age. The impact of initial HIV infection on five epigenetic measures of aging was examined before and approximately 3 years after HIV infection in the same individuals (n=102). Significant epigenetic age acceleration (median 1.9-4.8 years) and estimated telomere length shortening (all p

Identifiants

DOI: 10.1016/j.isci.2022.104488 PMID: 35880029 PMC: PMC9308149
pubmed: 35880029
doi: 10.1016/j.isci.2022.104488
pii: S2589-0042(22)00759-3
pmc: PMC9308149
doi:

Types de publication

Journal Article

Langues

eng

Pagination

104488

Subventions

Organisme : NHLBI NIH HHS
ID : U01 HL146333
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL146208
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG030327
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL146201
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL146193
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG052340
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR003098
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA016042
Pays : United States
Organisme : NIAID NIH HHS
ID : P30 AI028697
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001881
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL146240
Pays : United States

Commentaires et corrections

Type : ErratumIn

Informations de copyright

© 2022 The Author(s).

Déclaration de conflit d'intérêts

Peter Langfelder is a paid consultant for The Bioinformatics CRO, Inc and Quantigic Genomics, LLC. Steve Horvath is a founder of the non-profit Epigenetic Clock Development Foundation which plans to license several patents from his employer UC Regents. These patents list SH as inventor.

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Auteurs

Elizabeth Crabb Breen (EC)

Cousins Center for Psychoneuroimmunology, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, University of California Los Angeles, Los Angeles, CA 90095, USA.

Mary E Sehl (ME)

Division of Hematology-Oncology, Department of Medicine, David Geffen School of Medicine at UCLA, University of California Los Angeles, Los Angeles, CA 90095, USA.

Roger Shih (R)

Division of Hematology-Oncology, Department of Medicine, David Geffen School of Medicine at UCLA, University of California Los Angeles, Los Angeles, CA 90095, USA.

Peter Langfelder (P)

Center for Neurobehavioral Genetics, Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, Los Angeles, CA 90095, USA.
Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, University of California Los Angeles, Los Angeles, CA 90095, USA.

Ruibin Wang (R)

Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MA 21205, USA.

Steve Horvath (S)

Department of Human Genetics, David Geffen School of Medicine at UCLA, University of California Los Angeles, Los Angeles, CA 90095, USA.
Altos Labs, San Diego, CA 92121, USA.

Jay H Bream (JH)

Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Graduate Program in Immunology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.

Priya Duggal (P)

Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MA 21205, USA.

Jeremy Martinson (J)

Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA.

Steven M Wolinsky (SM)

Division of Infectious Diseases, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.

Otoniel Martínez-Maza (O)

Departments of Obstetrics & Gynecology and Microbiology, Immunology, & Molecular Genetics, David Geffen School of Medicine at UCLA, University of California Los Angeles, Los Angeles, CA 90095, USA.

Christina M Ramirez (CM)

Fielding School of Public Health, University of California Los Angeles, Los Angeles, CA 90095, USA.

Beth D Jamieson (BD)

Division of Hematology-Oncology, Department of Medicine, David Geffen School of Medicine at UCLA, University of California Los Angeles, Los Angeles, CA 90095, USA.

Classifications MeSH