Distorted time perception in patients with transient global amnesia: time perception task and imaging analysis.
Amnesia
Hippocampus
Magnetic resonance imaging
Memory disorders
Time perception
Transient global
Journal
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
ISSN: 1590-3478
Titre abrégé: Neurol Sci
Pays: Italy
ID NLM: 100959175
Informations de publication
Date de publication:
Oct 2022
Oct 2022
Historique:
received:
06
05
2022
accepted:
13
06
2022
pubmed:
19
7
2022
medline:
17
9
2022
entrez:
18
7
2022
Statut:
ppublish
Résumé
Transient global amnesia (TGA) is defined as a sudden and transient episode of memory loss and accompanied by temporal disorientation. However, the mechanism by which time distortion occurs is not clearly elucidated yet. Between March 2019 and November 2020, we subjected 30 TGA patients to several time perception tasks and analyzed their magnetic resonance image (MRI) scans and compared the results with age- and sex-matched control group. Among the 60 recruited subjects (64.5 ± 6.3 years), 70% were women. Fourteen patients had only anterograde amnesia. Furthermore, 46% of the patients with TGA (n = 14) had a history of Valsalva maneuver, and 70% of the patients (n = 21) had a pre-attack stress factor. The MRI scans of 14 patients (46.67%) showed hippocampal hyperintensity. With regard to the time production task, patients with TGA exhibited shorter times in all trials compared with their counterparts (5 s, 4.90 ± 1.16 vs. 5.53 ± 0.87; p value = 0.02: 15 s, 12.18 ± 4.55 vs. 14.42 ± 2.54; p value = 0.021). For the time comparison task, the number of correct answers given by patients with TGA was significantly lesser than that given by the control group (6.07 ± 1.23 vs. 6.90 ± 1.24; p value = 0.006). This is the first study to invesgating an altered time perception in patients with TGA. Although the exact neurophysiological mechanism remains unclear, our findings could aid in the elucidation of brain function across specific time frames.
Identifiants
pubmed: 35849197
doi: 10.1007/s10072-022-06219-0
pii: 10.1007/s10072-022-06219-0
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
5951-5958Subventions
Organisme : the Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Science and ICT
ID : NRF-2018R1C1B5086320
Organisme : Kangdong Sacred Heart Hospital Fund
ID : a grant no. 2020-07
Informations de copyright
© 2022. Fondazione Società Italiana di Neurologia.
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