Two HCN4 Channels Play Functional Roles in the Zebrafish Heart.
HCN4 channels
heart rate
ivabradine
morpholino
two-electrode voltage-clamp
zebrafish
Journal
Frontiers in physiology
ISSN: 1664-042X
Titre abrégé: Front Physiol
Pays: Switzerland
ID NLM: 101549006
Informations de publication
Date de publication:
2022
2022
Historique:
received:
22
03
2022
accepted:
31
05
2022
entrez:
18
7
2022
pubmed:
19
7
2022
medline:
19
7
2022
Statut:
epublish
Résumé
The HCN4 channel is essential for heart rate regulation in vertebrates by generating pacemaker potentials in the sinoatrial node. HCN4 channel abnormality may cause bradycardia and sick sinus syndrome, making it an important target for clinical research and drug discovery. The zebrafish is a popular animal model for cardiovascular research. They are potentially suitable for studying inherited heart diseases, including cardiac arrhythmia. However, it has not been determined how similar the ion channels that underlie cardiac automaticity are in zebrafish and humans. In the case of HCN4, humans have one gene, whereas zebrafish have two ortholog genes (
Identifiants
pubmed: 35846012
doi: 10.3389/fphys.2022.901571
pii: 901571
pmc: PMC9281569
doi:
Types de publication
Journal Article
Langues
eng
Pagination
901571Informations de copyright
Copyright © 2022 Liu, Kasuya, Zempo and Nakajo.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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