Recent clinical findings on the role of kinase inhibitors in COVID-19 management.
BTK
COVID-19
CRS
GSK-3
JAK/STAT
Kinase inhibitor
Signaling
p38 MAPK
Journal
Life sciences
ISSN: 1879-0631
Titre abrégé: Life Sci
Pays: Netherlands
ID NLM: 0375521
Informations de publication
Date de publication:
01 Oct 2022
01 Oct 2022
Historique:
received:
18
05
2022
revised:
07
07
2022
accepted:
11
07
2022
pubmed:
17
7
2022
medline:
24
8
2022
entrez:
16
7
2022
Statut:
ppublish
Résumé
The highly pathogenic, novel coronavirus disease (COVID-19) outbreak has emerged as a once-in-a-century pandemic with poor consequences, urgently calling for new therapeutics, cures, and supportive interventions. It has already affected over 250 million people worldwide; thereby, there is a need for novel therapies to alleviate the related complications. There is a paradigm shift in developing drugs and clinical practices to combat COVID-19. Several clinical trials have been performed or are testing diverse pharmacological interventions to alleviate viral load and complications such as cytokine release storm (CRS). Kinase-inhibitors have appeared as potential antiviral agents for COVID-19 patients due to their efficacy against CRS. Combination of kinase inhibitors with other therapies can achieve more efficacy against COVID-19. Based on the pre-clinical trials, kinase inhibitors such as Janus kinase-signal transducer and activator of transcription (JAK/STAT) inhibitors, Brutton's tyrosin kinase (BTK) inhibitors, p38 mitogen-activated protein kinases (p38 MAPK) inhibitors, Glycogen synthase kinase 3 (GSK-3) inhibitors can be a promising strategy against COVID-19. Kinase inhibitors possess crucial pharmacological properties for a successful re-purposing in terms of dual anti-inflammatory and anti-viral effects. This review will address the current clinical evidence and the newest discovery regarding the application of kinase inhibitors in COVID-19. An outlook on ongoing clinical trials (clinicaltrials.gov) and unpublished data is also presented here. Besides, Kinase inhibitors' function on COVID-19-mediated CRS is discussed.
Identifiants
pubmed: 35841979
pii: S0024-3205(22)00509-4
doi: 10.1016/j.lfs.2022.120809
pmc: PMC9278000
pii:
doi:
Substances chimiques
Antiviral Agents
0
p38 Mitogen-Activated Protein Kinases
EC 2.7.11.24
Glycogen Synthase Kinase 3
EC 2.7.11.26
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
120809Informations de copyright
Copyright © 2022 Elsevier Inc. All rights reserved.
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