Direct reprogramming of adult adipose-derived regenerative cells toward cardiomyocytes using six transcriptional factors.
Cell biology
Molecular biology
Stem cells research
Journal
iScience
ISSN: 2589-0042
Titre abrégé: iScience
Pays: United States
ID NLM: 101724038
Informations de publication
Date de publication:
15 Jul 2022
15 Jul 2022
Historique:
received:
05
08
2021
revised:
30
04
2022
accepted:
16
06
2022
entrez:
11
7
2022
pubmed:
12
7
2022
medline:
12
7
2022
Statut:
epublish
Résumé
It is widely accepted that adipose-derived regenerative cells (ADRCs) can differentiate into mesodermal lineage cells. However, reprogramming adult ADRCs into mature cardiomyocytes is challenging. We investigated the induction of myocardial differentiation in ADRCs via direct reprogramming using lentiviral gene transfer. First, we identified candidate transcriptional factors by performing RNA sequencing and ultimately confirmed that the combination of six unique factors (
Identifiants
pubmed: 35811849
doi: 10.1016/j.isci.2022.104651
pii: S2589-0042(22)00923-3
pmc: PMC9263527
doi:
Types de publication
Journal Article
Langues
eng
Pagination
104651Informations de copyright
© 2022 The Author(s).
Déclaration de conflit d'intérêts
All authors declare no competing interests.
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