Exploring the molecular interaction of mebendazole with bovine serum albumin using multi-spectroscopic approaches and molecular docking.


Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
08 07 2022
Historique:
received: 16 04 2022
accepted: 28 06 2022
entrez: 8 7 2022
pubmed: 9 7 2022
medline: 14 7 2022
Statut: epublish

Résumé

This article presents the binding interaction between mebendazole (MBZ) and bovine serum albumin. The interaction has been studied using different techniques, such as fluorescence quenching spectroscopy, UV-visible spectroscopy, synchronous fluorescence spectroscopy, fourier transform infrared, and fluorescence resonance energy transfer in addition to molecular docking. Results from Stern Volmer equation stated that the quenching for MBZ-BSA binding was static. The fluorescence quenching spectroscopic study was performed at three temperature settings. The binding constant (k

Identifiants

pubmed: 35804178
doi: 10.1038/s41598-022-15696-4
pii: 10.1038/s41598-022-15696-4
pmc: PMC9270458
doi:

Substances chimiques

Serum Albumin, Bovine 27432CM55Q
Mebendazole 81G6I5V05I

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

11582

Informations de copyright

© 2022. The Author(s).

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Auteurs

Reem N El Gammal (RN)

Department of Medicinal Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt. reemnashaat@std.mans.edu.eg.

Heba Elmansi (H)

Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt.

Ali A El-Emam (AA)

Department of Medicinal Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt.

Fathalla Belal (F)

Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt.

Mohammed E A Hammouda (MEA)

Department of Medicinal Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt.
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Horus University - Egypt (HUE), New Damietta, Egypt.

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Classifications MeSH