Macromolecular background signal and non-Gaussian metabolite diffusion determined in human brain using ultra-high diffusion weighting.
MR spectroscopy
apparent diffusion constants
brain
diffusion
fitting
macromolecules
microstructure
modeling
quantification
Journal
Magnetic resonance in medicine
ISSN: 1522-2594
Titre abrégé: Magn Reson Med
Pays: United States
ID NLM: 8505245
Informations de publication
Date de publication:
11 2022
11 2022
Historique:
revised:
08
05
2022
received:
01
02
2022
accepted:
31
05
2022
pubmed:
9
7
2022
medline:
27
8
2022
entrez:
8
7
2022
Statut:
ppublish
Résumé
Definition of a macromolecular MR spectrum based on diffusion properties rather than relaxation time differences and characterization of non-Gaussian diffusion of brain metabolites with strongly diffusion-weighted MR spectroscopy. Short echo time MRS with strong diffusion-weighting with b-values up to 25 ms/μm The motion compensation scheme prevented spurious signal decay reflected in very small apparent diffusion constants for macromolecular signal. Macromolecular background signal patterns were determined using multiple fit strategies. Signal decay corresponding to non-Gaussian metabolite diffusion was represented by biexponential fit models yielding parameter estimates for human gray matter that are in line with published rodent data. The optimal fit strategies used constraints for the signal decay of metabolites with limited signal contributions to the overall spectrum. The determined macromolecular spectrum based on diffusion properties deviates from the conventional one derived from longitudinal relaxation time differences calling for further investigation before use as experimental basis spectrum when fitting clinical MR spectra. The biexponential characterization of metabolite signal decay is the basis for investigations into pathologic alterations of microstructure.
Identifiants
pubmed: 35803740
doi: 10.1002/mrm.29367
pmc: PMC9545875
doi:
Substances chimiques
Macromolecular Substances
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1962-1977Informations de copyright
© 2022 The Authors. Magnetic Resonance in Medicine published by Wiley Periodicals LLC on behalf of International Society for Magnetic Resonance in Medicine.
Références
Magn Reson Med. 2022 Nov;88(5):1962-1977
pubmed: 35803740
Front Neurosci. 2018 Jan 19;12:2
pubmed: 29403347
Neuroimage. 2018 Nov 15;182:97-116
pubmed: 29155183
Neuroimage. 2013 Oct 15;80:220-33
pubmed: 23707579
Neuroimage. 2014 Feb 1;86:35-42
pubmed: 23639258
NMR Biomed. 2020 Sep;33(9):e4328
pubmed: 32542861
Magn Reson Med. 2015 Jun;73(6):2053-61
pubmed: 24986121
MAGMA. 2011 Jun;24(3):147-64
pubmed: 21424575
Magn Reson Med. 2018 Jun;79(6):3172-3193
pubmed: 29493816
Magn Reson Med. 1993 Dec;30(6):672-9
pubmed: 8139448
Radiology. 2014 Mar;270(3):658-79
pubmed: 24568703
Magn Reson Med. 2005 May;53(5):1025-32
pubmed: 15844150
Magn Reson Med. 2016 Nov 7;77(1):343-350
pubmed: 27851876
J Cereb Blood Flow Metab. 2012 Dec;32(12):2153-60
pubmed: 22929443
NMR Biomed. 2017 Jan;30(1):
pubmed: 27891691
Magn Reson Med. 2001 Nov;46(5):855-63
pubmed: 11675635
Magn Reson Med. 2018 Jun;79(6):2896-2901
pubmed: 29044690
Magn Reson Med. 2010 Oct;64(4):939-46
pubmed: 20564591
Magn Reson Med. 2013 Apr;69(4):931-6
pubmed: 22648904
J Cereb Blood Flow Metab. 2007 Mar;27(3):588-96
pubmed: 16788716
Magn Reson Med. 2018 Dec;80(6):2326-2338
pubmed: 29687927
Magn Reson Med. 2019 Oct;82(4):1424-1437
pubmed: 31148245
Neuroimage. 2019 Nov 15;202:116075
pubmed: 31398432
Magn Reson Med. 2018 Aug;80(2):462-473
pubmed: 29334141
Neuroimage. 2014 Apr 15;90:374-80
pubmed: 24382523
Magn Reson Med. 1994 Sep;32(3):294-302
pubmed: 7984061
NMR Biomed. 2001 Aug;14(5):325-31
pubmed: 11477653
Magn Reson Med. 2003 Jan;49(1):19-28
pubmed: 12509816
Magn Reson Med. 2017 Apr;77(4):1390-1398
pubmed: 27018415
J Alzheimers Dis. 2012;31 Suppl 3:S101-15
pubmed: 22543852
Brain Struct Funct. 2018 Nov;223(8):3841-3854
pubmed: 30088071
Proc Natl Acad Sci U S A. 2016 Jun 14;113(24):6671-6
pubmed: 27226303
NMR Biomed. 2017 Mar;30(3):
pubmed: 26797798
MAGMA. 2017 Oct;30(5):429-448
pubmed: 28382555
J Cereb Blood Flow Metab. 2000 Apr;20(4):736-46
pubmed: 10779018
Magn Reson Med. 2017 Jan;77(1):23-33
pubmed: 26715192
Magn Reson Med. 1993 Jul;30(1):38-44
pubmed: 8371672
NMR Biomed. 2014 May;27(5):495-506
pubmed: 24706330
NMR Biomed. 2021 May;34(5):e4257
pubmed: 32084297
Magn Reson Med. 2012 May;67(5):1203-9
pubmed: 22083562
NMR Biomed. 2021 May;34(5):e4206
pubmed: 31930768
NMR Biomed. 2021 May;34(5):e4393
pubmed: 33236818