Regioselective pyrrolizidine bis-spirooxindoles as efficient anti-amyloidogenic agents.
Alzheimer's disease
Amyloid-β
Protein misfolding
Raman spectroscopy
Spirooxindole
Journal
European journal of medicinal chemistry
ISSN: 1768-3254
Titre abrégé: Eur J Med Chem
Pays: France
ID NLM: 0420510
Informations de publication
Date de publication:
05 Oct 2022
05 Oct 2022
Historique:
received:
03
05
2022
revised:
13
06
2022
accepted:
21
06
2022
pubmed:
6
7
2022
medline:
17
8
2022
entrez:
5
7
2022
Statut:
ppublish
Résumé
Here, we report a microwave-assisted, one-pot, three-component, 1,3-dipolar cycloaddition reaction to produce highly regioselective and stereoselective bis-spirooxindoles as potential inhibitors against amyloid-β fibrillation. Ease of synthesis, promising anti-amyloidogenic activity, low toxicity, and in vitro blood brain barrier permeability makes these compounds attractive therapeutic leads to treat Alzheimer's disease.
Identifiants
pubmed: 35785723
pii: S0223-5234(22)00468-8
doi: 10.1016/j.ejmech.2022.114566
pii:
doi:
Substances chimiques
Amyloid beta-Peptides
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
114566Informations de copyright
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