The impact of prenatal and early-life arsenic exposure on epigenetic age acceleration among adults in Northern Chile.
arsenic
environmental exposure
epigenetic age acceleration
peripheral blood mononuclear cells
Journal
Environmental epigenetics
ISSN: 2058-5888
Titre abrégé: Environ Epigenet
Pays: England
ID NLM: 101675941
Informations de publication
Date de publication:
2022
2022
Historique:
received:
21
03
2022
revised:
02
05
2022
accepted:
31
05
2022
entrez:
30
6
2022
pubmed:
1
7
2022
medline:
1
7
2022
Statut:
epublish
Résumé
Exposure to arsenic affects millions of people globally. Changes in the epigenome may be involved in pathways linking arsenic to health or serve as biomarkers of exposure. This study investigated associations between prenatal and early-life arsenic exposure and epigenetic age acceleration (EAA) in adults, a biomarker of morbidity and mortality. DNA methylation was measured in peripheral blood mononuclear cells (PBMCs) and buccal cells from 40 adults (median age = 49 years) in Chile with and without high prenatal and early-life arsenic exposure. EAA was calculated using the Horvath, Hannum, PhenoAge, skin and blood, GrimAge, and DNA methylation telomere length clocks. We evaluated associations between arsenic exposure and EAA using robust linear models. Participants classified as with and without arsenic exposure had a median drinking water arsenic concentration at birth of 555 and 2 μg/l, respectively. In PBMCs, adjusting for sex and smoking, exposure was associated with a 6-year PhenoAge acceleration [
Identifiants
pubmed: 35769198
doi: 10.1093/eep/dvac014
pii: dvac014
pmc: PMC9235373
doi:
Types de publication
Journal Article
Langues
eng
Pagination
dvac014Subventions
Organisme : NIEHS NIH HHS
ID : P42 ES004705
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES031259
Pays : United States
Informations de copyright
© The Author(s) 2022. Published by Oxford University Press.
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