Immunodominant MHC-II (Major Histocompatibility Complex II) Restricted Epitopes in Human Apolipoprotein B.

Animals Apolipoproteins B / metabolism CD4-Positive T-Lymphocytes Coronary Artery Disease / metabolism Epitopes, T-Lymphocyte / genetics Humans Interferon-gamma / metabolism Major Histocompatibility Complex Mice Peptides / genetics
alleles autoimmunity coronary artery disease peptides workflow

Journal

Circulation research
ISSN: 1524-4571
Titre abrégé: Circ Res
Pays: United States
ID NLM: 0047103

Informations de publication

Date de publication:
22 07 2022
Historique:
pubmed: 30 6 2022
medline: 26 7 2022
entrez: 29 6 2022
Statut: ppublish

Résumé

CD (cluster of differentiation) 4 We selected 20 APOB-derived peptides (APOB Using stringent positive, negative, and crossover stimulation controls, we confirmed specificity of expansion-based protocols to detect CD4 Using 3 cohorts, each with ≈20 donors, we discovered and validated 6 immunodominant, HLA-II-restricted APOB epitopes. The immune response to these APOB epitopes correlated with coronary artery disease severity.

Sections du résumé

BACKGROUND
CD (cluster of differentiation) 4
METHODS
We selected 20 APOB-derived peptides (APOB
RESULTS
Using stringent positive, negative, and crossover stimulation controls, we confirmed specificity of expansion-based protocols to detect CD4
CONCLUSIONS
Using 3 cohorts, each with ≈20 donors, we discovered and validated 6 immunodominant, HLA-II-restricted APOB epitopes. The immune response to these APOB epitopes correlated with coronary artery disease severity.

Identifiants

DOI: 10.1161/CIRCRESAHA.122.321116 PMID: 35766025 PMC: PMC9536649
pubmed: 35766025
doi: 10.1161/CIRCRESAHA.122.321116
pmc: PMC9536649
mid: NIHMS1817996
doi:

Substances chimiques

Apolipoproteins B 0
Epitopes, T-Lymphocyte 0
Peptides 0
Interferon-gamma 82115-62-6

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

258-276

Subventions

Organisme : NHLBI NIH HHS
ID : P01 HL136275
Pays : United States
Organisme : NHLBI NIH HHS
ID : R35 HL145241
Pays : United States

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Auteurs

Payel Roy (P)

Center for Autoimmune Disease, Laboratory of Inflammation Biology (P.R., S.S.A.S., M.B., J.V., V.S., M.O., J.M., K.L.), La Jolla Institute for Immunology, CA.
ORCID: 0000-0003-2511-068X

John Sidney (J)

Center for Infectious Disease and Vaccine Research (J.S., C.S.L.A., P.R., D.M., B.P., A.S.), La Jolla Institute for Immunology, CA.

Cecilia S Lindestam Arlehamn (CS)

Center for Infectious Disease and Vaccine Research (J.S., C.S.L.A., P.R., D.M., B.P., A.S.), La Jolla Institute for Immunology, CA.
ORCID: 0000-0001-7302-8002

Elizabeth Phillips (E)

Department of Medicine, Department of Pharmacology, Department of Pathology, Microbiology and Immunology (E.P.), Vanderbilt University Medical Center, Nashville, TN.
Institute for Immunology and Infectious Diseases, Murdoch University, Perth, WA (E.P., S.M.).

Simon Mallal (S)

Department of Medicine (S.M.), Vanderbilt University Medical Center, Nashville, TN.
Institute for Immunology and Infectious Diseases, Murdoch University, Perth, WA (E.P., S.M.).
ORCID: 0000-0002-7036-1309

Sujit Silas Armstrong Suthahar (SS)

Center for Autoimmune Disease, Laboratory of Inflammation Biology (P.R., S.S.A.S., M.B., J.V., V.S., M.O., J.M., K.L.), La Jolla Institute for Immunology, CA.

Monica Billitti (M)

Center for Autoimmune Disease, Laboratory of Inflammation Biology (P.R., S.S.A.S., M.B., J.V., V.S., M.O., J.M., K.L.), La Jolla Institute for Immunology, CA.

Paul Rubiro (P)

Center for Infectious Disease and Vaccine Research (J.S., C.S.L.A., P.R., D.M., B.P., A.S.), La Jolla Institute for Immunology, CA.
ORCID: 0000-0002-6001-643X

Daniel Marrama (D)

Center for Infectious Disease and Vaccine Research (J.S., C.S.L.A., P.R., D.M., B.P., A.S.), La Jolla Institute for Immunology, CA.

Fabrizio Drago (F)

Cardiovascular Division, Department of Medicine, Cardiovascular Research Center, University of Virginia, Charlottesville (F.D., C.A.M.).
ORCID: 0000-0002-8591-7103

Jenifer Vallejo (J)

Center for Autoimmune Disease, Laboratory of Inflammation Biology (P.R., S.S.A.S., M.B., J.V., V.S., M.O., J.M., K.L.), La Jolla Institute for Immunology, CA.

Vasantika Suryawanshi (V)

Center for Autoimmune Disease, Laboratory of Inflammation Biology (P.R., S.S.A.S., M.B., J.V., V.S., M.O., J.M., K.L.), La Jolla Institute for Immunology, CA.
ORCID: 0000-0003-1497-7480

Marco Orecchioni (M)

Center for Autoimmune Disease, Laboratory of Inflammation Biology (P.R., S.S.A.S., M.B., J.V., V.S., M.O., J.M., K.L.), La Jolla Institute for Immunology, CA.
ORCID: 0000-0002-3602-8510

Jeffrey Makings (J)

Center for Autoimmune Disease, Laboratory of Inflammation Biology (P.R., S.S.A.S., M.B., J.V., V.S., M.O., J.M., K.L.), La Jolla Institute for Immunology, CA.

Paul J Kim (PJ)

Division of Cardiovascular Medicine, Department of Medicine (P.J.K.), University of California, San Diego, La Jolla.

Coleen A McNamara (CA)

Cardiovascular Division, Department of Medicine, Cardiovascular Research Center, University of Virginia, Charlottesville (F.D., C.A.M.).
ORCID: 0000-0002-0049-9986

Bjoern Peters (B)

Center for Infectious Disease and Vaccine Research (J.S., C.S.L.A., P.R., D.M., B.P., A.S.), La Jolla Institute for Immunology, CA.
Department of Medicine (B.P., A.S.), University of California, San Diego, La Jolla.

Alessandro Sette (A)

Center for Infectious Disease and Vaccine Research (J.S., C.S.L.A., P.R., D.M., B.P., A.S.), La Jolla Institute for Immunology, CA.
Department of Medicine (B.P., A.S.), University of California, San Diego, La Jolla.

Klaus Ley (K)

Center for Autoimmune Disease, Laboratory of Inflammation Biology (P.R., S.S.A.S., M.B., J.V., V.S., M.O., J.M., K.L.), La Jolla Institute for Immunology, CA.
Department of Bioengineering (K.L.), University of California, San Diego, La Jolla.
ORCID: 0000-0001-9339-3672

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Classifications MeSH

Recherchemedicale.com › Eucaryotes › Animaux › Immunodominant MHC-II (Major...
Recherchemedicale.com › Acides aminés, peptides et protéines › Protéines › Lipoprotéines › Apolipoprotéines › Apolipoprotéines B › Immunodominant MHC-II (Major...
Recherchemedicale.com › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Lymphocytes T CD4+ › Immunodominant MHC-II (Major...
Recherchemedicale.com › Maladies cardiovasculaires › Maladies vasculaires › Ischémie myocardique › Maladie coronarienne › Maladie des artères coronaires › Immunodominant MHC-II (Major...
Recherchemedicale.com › Facteurs biologiques › Antigènes › Épitopes › Déterminants antigéniques des lymphocytes T › Immunodominant MHC-II (Major...
Recherchemedicale.com › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Immunodominant MHC-II (Major...
Recherchemedicale.com › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Lymphokines › Facteurs d'activation des macrophages › Interféron gamma › Immunodominant MHC-II (Major...
Recherchemedicale.com › Phénomènes du système immunitaire › Phénomènes immunogénétiques › Complexe majeur d'histocompatibilité › Immunodominant MHC-II (Major...
Recherchemedicale.com › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Immunodominant MHC-II (Major...
Recherchemedicale.com › Acides aminés, peptides et protéines › Peptides › Immunodominant MHC-II (Major...