Development of quantum dot-phthalocyanine integrated G-quadruplex /double-stranded DNA biosensor.

Animals Biosensing Techniques DNA Ions Isoindoles Mammals Quantum Dots
Biosensor G-quadruplex Phthalocyanine Quantum dot

Journal

Analytical biochemistry
ISSN: 1096-0309
Titre abrégé: Anal Biochem
Pays: United States
ID NLM: 0370535

Informations de publication

Date de publication:
01 10 2022
Historique:
received: 21 03 2022
revised: 31 05 2022
accepted: 08 06 2022
pubmed: 25 6 2022
medline: 24 8 2022
entrez: 24 6 2022
Statut: ppublish

Résumé

In the present study, the phthalocyanine (Pc) integrated mercaptopropionic acid capped quantum dot (mpa@QD) biosensor has been developed for the quantitative determination of G-quadruplex and double-stranded DNA. The working principle of the developed biosensor platform is based on the quenching of the emission signal of the mpa@QD in the presence of Pc (closed position) and the recovery of the fluorescence signal in the presence of DNA (open position). The parameters affecting biosensor performance, such as Pc type and concentration, were optimized. Since the developed biosensor aimed to determine G-quadruplex and double-stranded DNA in biological samples, the effect of common ions (such as Na

Identifiants

DOI: 10.1016/j.ab.2022.114777 PMID: 35750250
pubmed: 35750250
pii: S0003-2697(22)00233-0
doi: 10.1016/j.ab.2022.114777
pii:
doi:

Substances chimiques

Ions 0
Isoindoles 0
DNA 9007-49-2
phthalocyanine V5PUF4VLGY

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

114777

Informations de copyright

Copyright © 2022 Elsevier Inc. All rights reserved.

Auteurs

Ayşe Topcu (A)

Department of Basic Pharmaceutical Sciences, Analytical Chemistry Division, Faculty of Pharmacy, Sivas Cumhuriyet University, 58140, Sivas, Turkey.

Esra Bağda (E)

Department of Basic Pharmaceutical Sciences, Analytical Chemistry Division, Faculty of Pharmacy, Sivas Cumhuriyet University, 58140, Sivas, Turkey. Electronic address: esraer@cumhuriyet.edu.tr.

Tülay Oymak (T)

Department of Basic Pharmaceutical Sciences, Analytical Chemistry Division, Faculty of Pharmacy, Sivas Cumhuriyet University, 58140, Sivas, Turkey.

Mahmut Durmuş (M)

Gebze Technical University, Department of Chemistry, Gebze, 41400, Kocaeli, Turkey.

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Classifications MeSH

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Recherchemedicale.com › Techniques d'investigation › Techniques de sonde moléculaire › Techniques de biocapteur › Development of quantum dot-phthalocyanine...
Recherchemedicale.com › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ADN › Development of quantum dot-phthalocyanine...
Recherchemedicale.com › Produits chimiques inorganiques › Électrolytes › Ions › Development of quantum dot-phthalocyanine...
Recherchemedicale.com › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Isoindoles › Development of quantum dot-phthalocyanine...
Recherchemedicale.com › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Development of quantum dot-phthalocyanine...
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