Malnutrition Is Highly Prevalent in Patients With Chronic Pancreatitis and Characterized by Loss of Skeletal Muscle Mass but Absence of Impaired Physical Function.
GLIM
chronic pancreatitis
handgrip strength
malnutrition
sarcopenia
Journal
Frontiers in nutrition
ISSN: 2296-861X
Titre abrégé: Front Nutr
Pays: Switzerland
ID NLM: 101642264
Informations de publication
Date de publication:
2022
2022
Historique:
received:
04
03
2022
accepted:
09
05
2022
entrez:
20
6
2022
pubmed:
21
6
2022
medline:
21
6
2022
Statut:
epublish
Résumé
Patients with chronic pancreatitis (CP) have an increased risk of malnutrition, a condition linked to reduced muscle mass and physical performance. We have investigated the risk factors, phenotypic presentation, and health implications associated with malnutrition in CP. In a multicenter cross-sectional study we recruited patients with confirmed CP and healthy volunteers as a control group. Malnutrition was diagnosed according to the criteria proposed by the Global Leadership Initiative on Malnutrition. We performed detailed examinations of body composition and physical function as well as testing of routine blood parameters and markers of inflammation. We included 66 patients [mean (±SD) age: 56.0 (±14.5) years; 51 males] and an equal number of age- and sex-matched controls. Moderate malnutrition was diagnosed in 21% ( Malnutrition is a frequent complication of CP characterized by loss of skeletal muscle mass. As this condition becomes evident only at an advanced stage, regular testing for altered body composition is recommended. Suitable biomarkers and the link between loss of muscle mass and physical function require further investigation. [https://clinicaltrials.gov/ct2/show/NCT04474743], identifier [NCT04474743].
Sections du résumé
Background/Aims
UNASSIGNED
Patients with chronic pancreatitis (CP) have an increased risk of malnutrition, a condition linked to reduced muscle mass and physical performance. We have investigated the risk factors, phenotypic presentation, and health implications associated with malnutrition in CP.
Materials and Methods
UNASSIGNED
In a multicenter cross-sectional study we recruited patients with confirmed CP and healthy volunteers as a control group. Malnutrition was diagnosed according to the criteria proposed by the Global Leadership Initiative on Malnutrition. We performed detailed examinations of body composition and physical function as well as testing of routine blood parameters and markers of inflammation.
Results
UNASSIGNED
We included 66 patients [mean (±SD) age: 56.0 (±14.5) years; 51 males] and an equal number of age- and sex-matched controls. Moderate malnutrition was diagnosed in 21% (
Conclusion
UNASSIGNED
Malnutrition is a frequent complication of CP characterized by loss of skeletal muscle mass. As this condition becomes evident only at an advanced stage, regular testing for altered body composition is recommended. Suitable biomarkers and the link between loss of muscle mass and physical function require further investigation.
Clinical Trial Registration
UNASSIGNED
[https://clinicaltrials.gov/ct2/show/NCT04474743], identifier [NCT04474743].
Identifiants
pubmed: 35719155
doi: 10.3389/fnut.2022.889489
pmc: PMC9202591
doi:
Banques de données
ClinicalTrials.gov
['NCT04474743']
Types de publication
Journal Article
Langues
eng
Pagination
889489Informations de copyright
Copyright © 2022 Wiese, Gärtner, von Essen, Doller, Frost, Tran, Weiss, Meyer, Valentini, Garbe, Metges, Bannert, Sautter, Ehlers, Jaster, Lamprecht, Steveling, Lerch and Aghdassi.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
J Am Med Dir Assoc. 2020 Mar;21(3):300-307.e2
pubmed: 32033882
Eur J Clin Nutr. 2022 Mar;76(3):397-400
pubmed: 34282291
World J Gastroenterol. 2021 Sep 14;27(34):5775-5792
pubmed: 34629801
Anticancer Res. 2012 May;32(5):1991-8
pubmed: 22593477
Nutr Clin Pract. 2019 Oct;34 Suppl 1:S13-S26
pubmed: 31535736
Clin Gastroenterol Hepatol. 2010 Apr;8(4):384-90
pubmed: 20036762
Dig Dis Sci. 1994 May;39(5):993-8
pubmed: 8174441
Clin Nutr ESPEN. 2021 Jun;43:290-295
pubmed: 34024529
Nutrition. 2006 Jul-Aug;22(7-8):750-7
pubmed: 16815489
J Gastroenterol Hepatol. 2008 Sep;23(9):1378-83
pubmed: 18554234
Ter Arkh. 2020 Dec 15;92(12):43-47
pubmed: 33720572
Nutr Clin Pract. 2014 Jun;29(3):348-54
pubmed: 24727205
Dig Liver Dis. 2022 May;54(5):654-662
pubmed: 34544675
Nutr Clin Pract. 2019 Jun;34(3):387-399
pubmed: 30101991
Pancreatology. 2021 Jan;21(1):34-41
pubmed: 33303371
Age Ageing. 2019 Jan 1;48(1):16-31
pubmed: 30312372
Clin Nutr. 2019 Feb;38(1):1-9
pubmed: 30181091
J Gastroenterol Hepatol. 2021 Mar;36(3):588-600
pubmed: 32864758
J Am Med Dir Assoc. 2019 Jan;20(1):22-27
pubmed: 30580819
Gut. 1998 Apr;42(4):551-4
pubmed: 9616319
Eur J Clin Nutr. 2013 Dec;67(12):1271-6
pubmed: 24129361
World J Gastroenterol. 2016 Feb 21;22(7):2304-13
pubmed: 26900292
Ageing Res Rev. 2016 Nov;31:1-8
pubmed: 27592340
Curr Opin Gastroenterol. 2015 Sep;31(5):395-9
pubmed: 26107390
Med Sci Sports Exerc. 2004 Mar;36(3):556
pubmed: 15076800
Pancreas. 2018 Sep;47(8):1015-1018
pubmed: 30074926
Dig Liver Dis. 2006 Feb;38(2):109-15
pubmed: 16243011
Clin Nutr. 2020 Mar;39(3):612-631
pubmed: 32008871
JOP. 2010 Mar 05;11(2):158-62
pubmed: 20208327
United European Gastroenterol J. 2017 Mar;5(2):153-199
pubmed: 28344786
Trop Gastroenterol. 2010 Jul-Sep;31(3):169-74
pubmed: 21560520
Pancreatology. 2019 Mar;19(2):245-251
pubmed: 30665702
Nutr J. 2010 Sep 14;9:36
pubmed: 20840739
Eur J Intern Med. 2013 Apr;24(3):203-6
pubmed: 23375619
Maturitas. 2017 Feb;96:10-15
pubmed: 28041587
Gastroenterology. 2017 Dec;153(6):1544-1554.e2
pubmed: 28918191
Z Gastroenterol. 2015 Dec;53(12):1447-95
pubmed: 26666283
Indian J Gastroenterol. 2011 Mar;30(2):78-83
pubmed: 21509539
Porto Biomed J. 2021 Feb 11;6(1):e123
pubmed: 33884319