Deciphering the balance of IL-6/IL-10 cytokines in severe to critical COVID-19 patients.
COVID-19
Cytokine storm
Interleukin 10
Interleukin 6
SARS-CoV-2
Journal
Immunobiology
ISSN: 1878-3279
Titre abrégé: Immunobiology
Pays: Netherlands
ID NLM: 8002742
Informations de publication
Date de publication:
07 2022
07 2022
Historique:
received:
14
02
2022
revised:
29
05
2022
accepted:
06
06
2022
pubmed:
13
6
2022
medline:
3
8
2022
entrez:
12
6
2022
Statut:
ppublish
Résumé
The severity of COVID-19 is largely determined by the inflammatory response, a "Cytokine storm," that involves both pro- and anti-inflammatory cytokines. In the current study we investigated the balance of pro- and anti-inflammatory status as represented by the levels of IL-6/IL-10 in severe to critical COVID-19 patients. 66 confirmed COVID-19 patients admitted to the ICU were categorized into groups according to the mortality and respiratory failure. Data were collected retrospectively in ICU, including a peripheral immune cells and infection-related biomarker CRP. The measurements of cytokine levels were performed by Immulite analyzer for IL-6 and ELISA sandwich for IL-10. In addition, longitudinal measurement of IL-6 was performed during 5 days post admission. Longitudinal assays showed that IL-6 was sustained at a medium level within 5 days post admission in severe cases who survived or not requiring mechanical ventilation, whereas it was sustained at high levels throughout the disease course in either deceased cases or who developed respiratory failure. The ratio of IL-6/lymphocytes was positively correlated with the risk of mortality, while IL-10/lymphocytes ratio could predict respiratory failure in ICU. IL-6/IL-10 profiling revealed that deceased patients have different magnitudes of both IL-6 and IL-10 cytokine release. Notably, excessive levels of IL-6 concomitant with high levels of IL-10 were more common in diseased COVID-19 patients. Taking into account the IL-6/IL-10 profiling may help clinicians to identify the right time of anti-inflammation treatment and select patients who will respond to anti-cytokine therapies and maintain an adequate inflammatory response for SARS-CoV-2 clearance.
Identifiants
pubmed: 35691133
pii: S0171-2985(22)00062-6
doi: 10.1016/j.imbio.2022.152236
pmc: PMC9173832
pii:
doi:
Substances chimiques
Anti-Inflammatory Agents
0
Cytokines
0
IL10 protein, human
0
IL6 protein, human
0
Interleukin-6
0
Interleukin-10
130068-27-8
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
152236Informations de copyright
Copyright © 2022. Published by Elsevier GmbH.
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