Drug-Eluting Rubber Bands for Tissue Ligation.
controlled release
drug delivery
drug release
elastomer
hemorrhoids
pain management
rubber
Journal
ACS applied materials & interfaces
ISSN: 1944-8252
Titre abrégé: ACS Appl Mater Interfaces
Pays: United States
ID NLM: 101504991
Informations de publication
Date de publication:
22 Jun 2022
22 Jun 2022
Historique:
pubmed:
8
6
2022
medline:
24
6
2022
entrez:
7
6
2022
Statut:
ppublish
Résumé
Rubber band ligation is a commonly used method for the removal of tissue abnormalities. Most often, rubber band ligation is performed to remove internal hemorrhoids unresponsive to first line treatments to avoid surgery. While the procedure is considered safe, patients experience mild to significant pain and discomfort until the tissue sloughs off. As patients often require multiple bandings and sessions, reducing these side effects can have a considerable effect on patient adherence and quality of life. To reduce pain and discomfort, we developed drug-eluting rubber bands for ligation procedures. We investigated the potential for a band to elute anesthetics and drug combinations to durably manage pain for a period of up to 5 days while exhibiting similar mechanical properties to conventional rubber bands. We show that the rubber bands retain their mechanical properties despite significant drug loading. Lidocaine, released from the bands, successfully altered the calcium dynamics of cardiomyocytes
Identifiants
pubmed: 35670525
doi: 10.1021/acsami.2c06175
pmc: PMC10015968
mid: NIHMS1864918
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
27675-27685Subventions
Organisme : NIAMS NIH HHS
ID : F31 AR079215
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
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