The Emerging Role of the Gut Microbiome in the Cancer Response to Immune Checkpoint Inhibitors: A Narrative Review.
cancer treatment
dysbiosis
immune checkpoint inhibitors
immunotherapy response
microbiome
Journal
Journal of immunotherapy and precision oncology
ISSN: 2590-017X
Titre abrégé: J Immunother Precis Oncol
Pays: United States
ID NLM: 101768397
Informations de publication
Date de publication:
Feb 2022
Feb 2022
Historique:
received:
14
04
2021
revised:
10
08
2021
accepted:
16
09
2021
entrez:
6
6
2022
pubmed:
7
6
2022
medline:
7
6
2022
Statut:
epublish
Résumé
The discovery of immune checkpoint inhibitors (ICIs) has revolutionized the care of cancer patients. However, the response to ICI therapy exhibits substantial interindividual variability. Efforts have been directed to identify biomarkers that predict the clinical response to ICIs. In recent years, the gut microbiome has emerged as a critical player that influences the efficacy of immunotherapy. An increasing number of studies have suggested that the baseline composition of a patient's gut microbiota and its dysbiosis are correlated with the outcome of cancer immunotherapy. This review tackles the rapidly growing body of evidence evaluating the relationship between the gut microbiome and the response to ICI therapy. Additionally, this review highlights the impact of antibiotic-induced dysbiosis on ICI efficacy and discusses the possible therapeutic interventions to optimize the gut microbiota composition to augment immunotherapy efficacy.
Identifiants
pubmed: 35663831
doi: 10.36401/JIPO-21-10
pmc: PMC9138420
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
13-25Déclaration de conflit d'intérêts
Conflict of Interest: Dr. Yeung is a member of an expert panel for Celgene, Inc. The other authors have nothing to disclose.
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