Distinct but overlapping roles of LRRTM1 and LRRTM2 in developing and mature hippocampal circuits.

Animals Hippocampus / physiology Long-Term Potentiation / physiology Membrane Proteins / metabolism Mice Nerve Tissue Proteins / metabolism Neural Cell Adhesion Molecules / metabolism Synapses / physiology
LRRTMs cognition hippocampus mouse neuroscience synapse development synapse organization synaptic plasticity

Journal

eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614

Informations de publication

Date de publication:
06 06 2022
Historique:
received: 09 11 2020
accepted: 20 05 2022
entrez: 6 6 2022
pubmed: 7 6 2022
medline: 9 6 2022
Statut: epublish

Résumé

LRRTMs are postsynaptic cell adhesion proteins that have region-restricted expression in the brain. To determine their role in the molecular organization of synapses in vivo, we studied synapse development and plasticity in hippocampal neuronal circuits in mice lacking both

Identifiants

DOI: 10.7554/eLife.64742 PMID: 35662394 PMC: PMC9170246
pubmed: 35662394
doi: 10.7554/eLife.64742
pii: 64742
pmc: PMC9170246
doi:
pii:

Substances chimiques

LRRTM1 protein, mouse 0
LRRTM2 protein, mouse 0
Membrane Proteins 0
Nerve Tissue Proteins 0
Neural Cell Adhesion Molecules 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : CIHR
ID : MOP-130526
Pays : Canada
Organisme : CIHR
ID : FND-154286
Pays : Canada
Organisme : CIHR
ID : FDN-143206
Pays : Canada
Organisme : CIHR
ID : MOP-84241
Pays : Canada
Organisme : CIHR
ID : MOP-142209
Pays : Canada
Organisme : CIHR
ID : PJT-173550
Pays : Canada

Informations de copyright

© 2022, Dhume et al.

Déclaration de conflit d'intérêts

SD, SC, FM, PT, SA, BK, SO, RR, HK, SB, YW, MJ, AC, TS No competing interests declared, NB Reviewing editor, eLife

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Auteurs

Shreya H Dhume (SH)

Neuroscience Research Program, Kleysen Institute for Advanced Medicine, Health Sciences Centre, Winnipeg, Canada.
Department of Physiology and Pathophysiology, University of Manitoba, Winnipeg, Canada.

Steven A Connor (SA)

Department of Psychiatry and Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, Canada.
Department of Biology, York University, Toronto, Canada.

Fergil Mills (F)

Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, Canada.

Parisa Karimi Tari (PK)

Department of Psychiatry and Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, Canada.
Department of Biology, York University, Toronto, Canada.

Sarah H M Au-Yeung (SHM)

Department of Psychiatry and Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, Canada.

Benjamin Karimi (B)

Neuroscience Research Program, Kleysen Institute for Advanced Medicine, Health Sciences Centre, Winnipeg, Canada.
Department of Physiology and Pathophysiology, University of Manitoba, Winnipeg, Canada.

Shinichiro Oku (S)

Neuroscience Research Program, Kleysen Institute for Advanced Medicine, Health Sciences Centre, Winnipeg, Canada.
Department of Physiology and Pathophysiology, University of Manitoba, Winnipeg, Canada.
Department of Psychiatry and Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, Canada.
ORCID: 0000-0002-1916-1870

Reiko T Roppongi (RT)

Neuroscience Research Program, Kleysen Institute for Advanced Medicine, Health Sciences Centre, Winnipeg, Canada.
Department of Physiology and Pathophysiology, University of Manitoba, Winnipeg, Canada.

Hiroshi Kawabe (H)

Department of Molecular Neurobiology, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.
Division of Pathogenetic Signaling, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe, Japan.
Department of Gerontology, Laboratory of Molecular Life Science, Institute of Biomedical Research and Innovation, Foundation for Biomedical Research and Innovation at Kobe, Kobe, Japan.
Department of Pharmacology, Gunma University Graduate School of Medicine, Gunma, Japan.
ORCID: 0000-0001-5650-8696

Shernaz X Bamji (SX)

Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, Canada.
ORCID: 0000-0003-0102-9297

Yu Tian Wang (YT)

Division of Neurology, Department of Medicine and Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, Canada.
ORCID: 0000-0001-8592-0698

Nils Brose (N)

Department of Molecular Neurobiology, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.

Michael F Jackson (MF)

Department of Pharmacology and Therapeutics, University of Manitoba, Winnipeg, Canada.

Ann Marie Craig (AM)

Department of Psychiatry and Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, Canada.
ORCID: 0000-0002-8651-8200

Tabrez J Siddiqui (TJ)

Neuroscience Research Program, Kleysen Institute for Advanced Medicine, Health Sciences Centre, Winnipeg, Canada.
Department of Physiology and Pathophysiology, University of Manitoba, Winnipeg, Canada.
The Children's Hospital Research Institute of Manitoba, Winnipeg, Canada.
Program in Biomedical Engineering, University of Manitoba, Winnipeg, Canada.
ORCID: 0000-0002-6938-7827

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Classifications MeSH

Recherchemedicale.com › Eucaryotes › Animaux › Distinct but overlapping roles of LRRTM1 and...
Recherchemedicale.com › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Cortex cérébral › Hippocampe › Distinct but overlapping roles of LRRTM1 and...
Recherchemedicale.com › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Plasticité neuronale › Potentialisation à long terme › Distinct but overlapping roles of LRRTM1 and...
Recherchemedicale.com › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Distinct but overlapping roles of LRRTM1 and...
Recherchemedicale.com › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Distinct but overlapping roles of LRRTM1 and...
Recherchemedicale.com › Acides aminés, peptides et protéines › Protéines › Protéines de tissu nerveux › Distinct but overlapping roles of LRRTM1 and...
Recherchemedicale.com › Facteurs biologiques › Antigènes › Antigènes de surface › Molécules d'adhérence cellulaire › Molécules d'adhérence cellulaire neuronale › Molécules d'adhérence cellulaire neurales › Distinct but overlapping roles of LRRTM1 and...
Recherchemedicale.com › Cellules › Structures cellulaires › Membrane cellulaire › Structures de la membrane cellulaire › Jonctions intercellulaires › Synapses › Distinct but overlapping roles of LRRTM1 and...