Phosphodiesterase-5 Inhibitory Activity of Canthin-6-One Alkaloids and the Roots of Eurycoma longifolia and Eurycoma harmandiana.
Eurycoma harmandiana
Eurycoma longifolia
canthin-6-one alkaloids
erectile dysfunction
in vitro root culture
phosphodiesterase-5
Journal
Chemistry & biodiversity
ISSN: 1612-1880
Titre abrégé: Chem Biodivers
Pays: Switzerland
ID NLM: 101197449
Informations de publication
Date de publication:
Jul 2022
Jul 2022
Historique:
received:
10
02
2022
accepted:
01
06
2022
pubmed:
3
6
2022
medline:
28
7
2022
entrez:
2
6
2022
Statut:
ppublish
Résumé
Eurycoma longifolia (EL) and Eurycoma harmandiana (EH) are natural medicinal plants belonging to the Simaroubaceae family, and are well-known for their ability to enhance male sexual performance. The present study investigated the phosphodiesterase-5 (PDE-5) inhibitory activity of intact roots of EL and EH. Additionally, canthin-6-one alkaloids, β-carboline alkaloids, and quassinoids were also screened for PDE-5 inhibitory activity. We developed in vitro root and callus cultures of EL and EH to determine their PDE-5 inhibitory activity. Our results indicated that canthin-6-one alkaloids, which include canthin-6-one-9-O-β-D-glucopyranoside, 9-methoxycanthin-6-one, canthin-6-one, and 9-hydroxycanthin-6-one, exhibited PDE-5 enzymatic inhibitory activity, with IC
Identifiants
pubmed: 35652145
doi: 10.1002/cbdv.202200121
doi:
Substances chimiques
Alkaloids
0
Carbolines
0
Indole Alkaloids
0
Plant Extracts
0
canthin-6-one
3FK17S759N
Cyclic Nucleotide Phosphodiesterases, Type 5
EC 3.1.4.35
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e202200121Subventions
Organisme : Faculty of Pharmaceutical Sciences, Khon Kaen University, Thailand
ID : 64-1(1)/2564
Organisme : NSRF
ID : C00SC65030008
Informations de copyright
© 2022 Wiley-VHCA AG, Zurich, Switzerland.
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