Traction Bronchiectasis/Bronchiolectasis on CT Scans in Relationship to Clinical Outcomes and Mortality: The COPDGene Study.
Journal
Radiology
ISSN: 1527-1315
Titre abrégé: Radiology
Pays: United States
ID NLM: 0401260
Informations de publication
Date de publication:
09 2022
09 2022
Historique:
pubmed:
1
6
2022
medline:
25
8
2022
entrez:
31
5
2022
Statut:
ppublish
Résumé
Background The clinical impact of interstitial lung abnormalities (ILAs) on poor prognosis has been reported in many studies, but risk stratification in ILA will contribute to clinical practice. Purpose To investigate the association of traction bronchiectasis/bronchiolectasis index (TBI) with mortality and clinical outcomes in individuals with ILA by using the COPDGene cohort. Materials and Methods This study was a secondary analysis of prospectively collected data. Chest CT scans of participants with ILA for traction bronchiectasis/bronchiolectasis were evaluated and outcomes were compared with participants without ILA from the COPDGene study (January 2008 to June 2011). TBI was classified as follows: TBI-0, ILA without traction bronchiectasis/bronchiolectasis; TBI-1, ILA with bronchiolectasis but without bronchiectasis or architectural distortion; TBI-2, ILA with mild to moderate traction bronchiectasis; and TBI-3, ILA with severe traction bronchiectasis and/or honeycombing. Clinical outcomes and overall survival were compared among the TBI groups and the non-ILA group by using multivariable linear regression model and Cox proportional hazards model, respectively. Results Overall, 5295 participants (median age, 59 years; IQR, 52-66 years; 2779 men) were included, and 582 participants with ILA and 4713 participants without ILA were identified. TBI groups were associated with poorer clinical outcomes such as quality of life scores in the multivariable linear regression model (TBI-0: coefficient, 3.2 [95% CI: 0.6, 5.7;
Identifiants
pubmed: 35638925
doi: 10.1148/radiol.212584
pmc: PMC9434811
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
694-701Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL149877
Pays : United States
Organisme : NHLBI NIH HHS
ID : K08 HL140087
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL149861
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL089856
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL116473
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL122464
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA209414
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA203636
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL089897
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL135142
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL111024
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL130974
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA240592
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL137927
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL147148
Pays : United States
Commentaires et corrections
Type : CommentIn
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