Traction Bronchiectasis/Bronchiolectasis on CT Scans in Relationship to Clinical Outcomes and Mortality: The COPDGene Study.


Journal

Radiology
ISSN: 1527-1315
Titre abrégé: Radiology
Pays: United States
ID NLM: 0401260

Informations de publication

Date de publication:
09 2022
Historique:
pubmed: 1 6 2022
medline: 25 8 2022
entrez: 31 5 2022
Statut: ppublish

Résumé

Background The clinical impact of interstitial lung abnormalities (ILAs) on poor prognosis has been reported in many studies, but risk stratification in ILA will contribute to clinical practice. Purpose To investigate the association of traction bronchiectasis/bronchiolectasis index (TBI) with mortality and clinical outcomes in individuals with ILA by using the COPDGene cohort. Materials and Methods This study was a secondary analysis of prospectively collected data. Chest CT scans of participants with ILA for traction bronchiectasis/bronchiolectasis were evaluated and outcomes were compared with participants without ILA from the COPDGene study (January 2008 to June 2011). TBI was classified as follows: TBI-0, ILA without traction bronchiectasis/bronchiolectasis; TBI-1, ILA with bronchiolectasis but without bronchiectasis or architectural distortion; TBI-2, ILA with mild to moderate traction bronchiectasis; and TBI-3, ILA with severe traction bronchiectasis and/or honeycombing. Clinical outcomes and overall survival were compared among the TBI groups and the non-ILA group by using multivariable linear regression model and Cox proportional hazards model, respectively. Results Overall, 5295 participants (median age, 59 years; IQR, 52-66 years; 2779 men) were included, and 582 participants with ILA and 4713 participants without ILA were identified. TBI groups were associated with poorer clinical outcomes such as quality of life scores in the multivariable linear regression model (TBI-0: coefficient, 3.2 [95% CI: 0.6, 5.7;

Identifiants

pubmed: 35638925
doi: 10.1148/radiol.212584
pmc: PMC9434811
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

694-701

Subventions

Organisme : NHLBI NIH HHS
ID : R01 HL149877
Pays : United States
Organisme : NHLBI NIH HHS
ID : K08 HL140087
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL149861
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL089856
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL116473
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL122464
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA209414
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA203636
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL089897
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL135142
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL111024
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL130974
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA240592
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL137927
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL147148
Pays : United States

Commentaires et corrections

Type : CommentIn

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Auteurs

Akinori Hata (A)

From the Ctr for Pulmonary Functional Imaging, Dept of Radiology (A.H., T. Hino, T. Hida, M.N., V.I.V., G.M.H., H. Hatabu), Pulmonary and Critical Care Division (R.K.P., A.A.M., G.R.W., G.M.H.), Dept of Radiology (R.S.J.E.), and Channing Division of Network Medicine (M.H.C., E.K.S.), Brigham and Women's Hospital and Harvard Medical School, Boston, Mass; Dept of Radiology, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan (A.H., M.Y., N.T.); Dept of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan (T. Hida, H. Honda, K.I.); Dept of Radiology, Kansai Medical University, Hirakata, Japan (O.H.); Dept of Radiology, Keio University School of Medicine, Tokyo, Japan (Y.Y., M.J.); Dept of Radiology, Hospital of the University of Pennsylvania, Philadelphia, Pa (T.A.); Dept of Radiology, Kansai Rosai Hospital, Amagasaki, Japan (T.J.); Dept of Environmental Health, Harvard TH Chan School of Public Health, Boston, Mass (D.C.C.); and Dept of Radiology, National Jewish Health, Denver, Colo (D.A.L.).

Takuya Hino (T)

From the Ctr for Pulmonary Functional Imaging, Dept of Radiology (A.H., T. Hino, T. Hida, M.N., V.I.V., G.M.H., H. Hatabu), Pulmonary and Critical Care Division (R.K.P., A.A.M., G.R.W., G.M.H.), Dept of Radiology (R.S.J.E.), and Channing Division of Network Medicine (M.H.C., E.K.S.), Brigham and Women's Hospital and Harvard Medical School, Boston, Mass; Dept of Radiology, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan (A.H., M.Y., N.T.); Dept of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan (T. Hida, H. Honda, K.I.); Dept of Radiology, Kansai Medical University, Hirakata, Japan (O.H.); Dept of Radiology, Keio University School of Medicine, Tokyo, Japan (Y.Y., M.J.); Dept of Radiology, Hospital of the University of Pennsylvania, Philadelphia, Pa (T.A.); Dept of Radiology, Kansai Rosai Hospital, Amagasaki, Japan (T.J.); Dept of Environmental Health, Harvard TH Chan School of Public Health, Boston, Mass (D.C.C.); and Dept of Radiology, National Jewish Health, Denver, Colo (D.A.L.).

Rachel K Putman (RK)

From the Ctr for Pulmonary Functional Imaging, Dept of Radiology (A.H., T. Hino, T. Hida, M.N., V.I.V., G.M.H., H. Hatabu), Pulmonary and Critical Care Division (R.K.P., A.A.M., G.R.W., G.M.H.), Dept of Radiology (R.S.J.E.), and Channing Division of Network Medicine (M.H.C., E.K.S.), Brigham and Women's Hospital and Harvard Medical School, Boston, Mass; Dept of Radiology, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan (A.H., M.Y., N.T.); Dept of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan (T. Hida, H. Honda, K.I.); Dept of Radiology, Kansai Medical University, Hirakata, Japan (O.H.); Dept of Radiology, Keio University School of Medicine, Tokyo, Japan (Y.Y., M.J.); Dept of Radiology, Hospital of the University of Pennsylvania, Philadelphia, Pa (T.A.); Dept of Radiology, Kansai Rosai Hospital, Amagasaki, Japan (T.J.); Dept of Environmental Health, Harvard TH Chan School of Public Health, Boston, Mass (D.C.C.); and Dept of Radiology, National Jewish Health, Denver, Colo (D.A.L.).

Masahiro Yanagawa (M)

From the Ctr for Pulmonary Functional Imaging, Dept of Radiology (A.H., T. Hino, T. Hida, M.N., V.I.V., G.M.H., H. Hatabu), Pulmonary and Critical Care Division (R.K.P., A.A.M., G.R.W., G.M.H.), Dept of Radiology (R.S.J.E.), and Channing Division of Network Medicine (M.H.C., E.K.S.), Brigham and Women's Hospital and Harvard Medical School, Boston, Mass; Dept of Radiology, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan (A.H., M.Y., N.T.); Dept of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan (T. Hida, H. Honda, K.I.); Dept of Radiology, Kansai Medical University, Hirakata, Japan (O.H.); Dept of Radiology, Keio University School of Medicine, Tokyo, Japan (Y.Y., M.J.); Dept of Radiology, Hospital of the University of Pennsylvania, Philadelphia, Pa (T.A.); Dept of Radiology, Kansai Rosai Hospital, Amagasaki, Japan (T.J.); Dept of Environmental Health, Harvard TH Chan School of Public Health, Boston, Mass (D.C.C.); and Dept of Radiology, National Jewish Health, Denver, Colo (D.A.L.).

Tomoyuki Hida (T)

From the Ctr for Pulmonary Functional Imaging, Dept of Radiology (A.H., T. Hino, T. Hida, M.N., V.I.V., G.M.H., H. Hatabu), Pulmonary and Critical Care Division (R.K.P., A.A.M., G.R.W., G.M.H.), Dept of Radiology (R.S.J.E.), and Channing Division of Network Medicine (M.H.C., E.K.S.), Brigham and Women's Hospital and Harvard Medical School, Boston, Mass; Dept of Radiology, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan (A.H., M.Y., N.T.); Dept of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan (T. Hida, H. Honda, K.I.); Dept of Radiology, Kansai Medical University, Hirakata, Japan (O.H.); Dept of Radiology, Keio University School of Medicine, Tokyo, Japan (Y.Y., M.J.); Dept of Radiology, Hospital of the University of Pennsylvania, Philadelphia, Pa (T.A.); Dept of Radiology, Kansai Rosai Hospital, Amagasaki, Japan (T.J.); Dept of Environmental Health, Harvard TH Chan School of Public Health, Boston, Mass (D.C.C.); and Dept of Radiology, National Jewish Health, Denver, Colo (D.A.L.).

Aravind A Menon (AA)

From the Ctr for Pulmonary Functional Imaging, Dept of Radiology (A.H., T. Hino, T. Hida, M.N., V.I.V., G.M.H., H. Hatabu), Pulmonary and Critical Care Division (R.K.P., A.A.M., G.R.W., G.M.H.), Dept of Radiology (R.S.J.E.), and Channing Division of Network Medicine (M.H.C., E.K.S.), Brigham and Women's Hospital and Harvard Medical School, Boston, Mass; Dept of Radiology, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan (A.H., M.Y., N.T.); Dept of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan (T. Hida, H. Honda, K.I.); Dept of Radiology, Kansai Medical University, Hirakata, Japan (O.H.); Dept of Radiology, Keio University School of Medicine, Tokyo, Japan (Y.Y., M.J.); Dept of Radiology, Hospital of the University of Pennsylvania, Philadelphia, Pa (T.A.); Dept of Radiology, Kansai Rosai Hospital, Amagasaki, Japan (T.J.); Dept of Environmental Health, Harvard TH Chan School of Public Health, Boston, Mass (D.C.C.); and Dept of Radiology, National Jewish Health, Denver, Colo (D.A.L.).

Osamu Honda (O)

From the Ctr for Pulmonary Functional Imaging, Dept of Radiology (A.H., T. Hino, T. Hida, M.N., V.I.V., G.M.H., H. Hatabu), Pulmonary and Critical Care Division (R.K.P., A.A.M., G.R.W., G.M.H.), Dept of Radiology (R.S.J.E.), and Channing Division of Network Medicine (M.H.C., E.K.S.), Brigham and Women's Hospital and Harvard Medical School, Boston, Mass; Dept of Radiology, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan (A.H., M.Y., N.T.); Dept of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan (T. Hida, H. Honda, K.I.); Dept of Radiology, Kansai Medical University, Hirakata, Japan (O.H.); Dept of Radiology, Keio University School of Medicine, Tokyo, Japan (Y.Y., M.J.); Dept of Radiology, Hospital of the University of Pennsylvania, Philadelphia, Pa (T.A.); Dept of Radiology, Kansai Rosai Hospital, Amagasaki, Japan (T.J.); Dept of Environmental Health, Harvard TH Chan School of Public Health, Boston, Mass (D.C.C.); and Dept of Radiology, National Jewish Health, Denver, Colo (D.A.L.).

Yoshitake Yamada (Y)

From the Ctr for Pulmonary Functional Imaging, Dept of Radiology (A.H., T. Hino, T. Hida, M.N., V.I.V., G.M.H., H. Hatabu), Pulmonary and Critical Care Division (R.K.P., A.A.M., G.R.W., G.M.H.), Dept of Radiology (R.S.J.E.), and Channing Division of Network Medicine (M.H.C., E.K.S.), Brigham and Women's Hospital and Harvard Medical School, Boston, Mass; Dept of Radiology, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan (A.H., M.Y., N.T.); Dept of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan (T. Hida, H. Honda, K.I.); Dept of Radiology, Kansai Medical University, Hirakata, Japan (O.H.); Dept of Radiology, Keio University School of Medicine, Tokyo, Japan (Y.Y., M.J.); Dept of Radiology, Hospital of the University of Pennsylvania, Philadelphia, Pa (T.A.); Dept of Radiology, Kansai Rosai Hospital, Amagasaki, Japan (T.J.); Dept of Environmental Health, Harvard TH Chan School of Public Health, Boston, Mass (D.C.C.); and Dept of Radiology, National Jewish Health, Denver, Colo (D.A.L.).

Mizuki Nishino (M)

From the Ctr for Pulmonary Functional Imaging, Dept of Radiology (A.H., T. Hino, T. Hida, M.N., V.I.V., G.M.H., H. Hatabu), Pulmonary and Critical Care Division (R.K.P., A.A.M., G.R.W., G.M.H.), Dept of Radiology (R.S.J.E.), and Channing Division of Network Medicine (M.H.C., E.K.S.), Brigham and Women's Hospital and Harvard Medical School, Boston, Mass; Dept of Radiology, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan (A.H., M.Y., N.T.); Dept of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan (T. Hida, H. Honda, K.I.); Dept of Radiology, Kansai Medical University, Hirakata, Japan (O.H.); Dept of Radiology, Keio University School of Medicine, Tokyo, Japan (Y.Y., M.J.); Dept of Radiology, Hospital of the University of Pennsylvania, Philadelphia, Pa (T.A.); Dept of Radiology, Kansai Rosai Hospital, Amagasaki, Japan (T.J.); Dept of Environmental Health, Harvard TH Chan School of Public Health, Boston, Mass (D.C.C.); and Dept of Radiology, National Jewish Health, Denver, Colo (D.A.L.).

Tetsuro Araki (T)

From the Ctr for Pulmonary Functional Imaging, Dept of Radiology (A.H., T. Hino, T. Hida, M.N., V.I.V., G.M.H., H. Hatabu), Pulmonary and Critical Care Division (R.K.P., A.A.M., G.R.W., G.M.H.), Dept of Radiology (R.S.J.E.), and Channing Division of Network Medicine (M.H.C., E.K.S.), Brigham and Women's Hospital and Harvard Medical School, Boston, Mass; Dept of Radiology, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan (A.H., M.Y., N.T.); Dept of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan (T. Hida, H. Honda, K.I.); Dept of Radiology, Kansai Medical University, Hirakata, Japan (O.H.); Dept of Radiology, Keio University School of Medicine, Tokyo, Japan (Y.Y., M.J.); Dept of Radiology, Hospital of the University of Pennsylvania, Philadelphia, Pa (T.A.); Dept of Radiology, Kansai Rosai Hospital, Amagasaki, Japan (T.J.); Dept of Environmental Health, Harvard TH Chan School of Public Health, Boston, Mass (D.C.C.); and Dept of Radiology, National Jewish Health, Denver, Colo (D.A.L.).

Vladimir I Valtchinov (VI)

From the Ctr for Pulmonary Functional Imaging, Dept of Radiology (A.H., T. Hino, T. Hida, M.N., V.I.V., G.M.H., H. Hatabu), Pulmonary and Critical Care Division (R.K.P., A.A.M., G.R.W., G.M.H.), Dept of Radiology (R.S.J.E.), and Channing Division of Network Medicine (M.H.C., E.K.S.), Brigham and Women's Hospital and Harvard Medical School, Boston, Mass; Dept of Radiology, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan (A.H., M.Y., N.T.); Dept of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan (T. Hida, H. Honda, K.I.); Dept of Radiology, Kansai Medical University, Hirakata, Japan (O.H.); Dept of Radiology, Keio University School of Medicine, Tokyo, Japan (Y.Y., M.J.); Dept of Radiology, Hospital of the University of Pennsylvania, Philadelphia, Pa (T.A.); Dept of Radiology, Kansai Rosai Hospital, Amagasaki, Japan (T.J.); Dept of Environmental Health, Harvard TH Chan School of Public Health, Boston, Mass (D.C.C.); and Dept of Radiology, National Jewish Health, Denver, Colo (D.A.L.).

Masahiro Jinzaki (M)

From the Ctr for Pulmonary Functional Imaging, Dept of Radiology (A.H., T. Hino, T. Hida, M.N., V.I.V., G.M.H., H. Hatabu), Pulmonary and Critical Care Division (R.K.P., A.A.M., G.R.W., G.M.H.), Dept of Radiology (R.S.J.E.), and Channing Division of Network Medicine (M.H.C., E.K.S.), Brigham and Women's Hospital and Harvard Medical School, Boston, Mass; Dept of Radiology, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan (A.H., M.Y., N.T.); Dept of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan (T. Hida, H. Honda, K.I.); Dept of Radiology, Kansai Medical University, Hirakata, Japan (O.H.); Dept of Radiology, Keio University School of Medicine, Tokyo, Japan (Y.Y., M.J.); Dept of Radiology, Hospital of the University of Pennsylvania, Philadelphia, Pa (T.A.); Dept of Radiology, Kansai Rosai Hospital, Amagasaki, Japan (T.J.); Dept of Environmental Health, Harvard TH Chan School of Public Health, Boston, Mass (D.C.C.); and Dept of Radiology, National Jewish Health, Denver, Colo (D.A.L.).

Hiroshi Honda (H)

From the Ctr for Pulmonary Functional Imaging, Dept of Radiology (A.H., T. Hino, T. Hida, M.N., V.I.V., G.M.H., H. Hatabu), Pulmonary and Critical Care Division (R.K.P., A.A.M., G.R.W., G.M.H.), Dept of Radiology (R.S.J.E.), and Channing Division of Network Medicine (M.H.C., E.K.S.), Brigham and Women's Hospital and Harvard Medical School, Boston, Mass; Dept of Radiology, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan (A.H., M.Y., N.T.); Dept of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan (T. Hida, H. Honda, K.I.); Dept of Radiology, Kansai Medical University, Hirakata, Japan (O.H.); Dept of Radiology, Keio University School of Medicine, Tokyo, Japan (Y.Y., M.J.); Dept of Radiology, Hospital of the University of Pennsylvania, Philadelphia, Pa (T.A.); Dept of Radiology, Kansai Rosai Hospital, Amagasaki, Japan (T.J.); Dept of Environmental Health, Harvard TH Chan School of Public Health, Boston, Mass (D.C.C.); and Dept of Radiology, National Jewish Health, Denver, Colo (D.A.L.).

Kousei Ishigami (K)

From the Ctr for Pulmonary Functional Imaging, Dept of Radiology (A.H., T. Hino, T. Hida, M.N., V.I.V., G.M.H., H. Hatabu), Pulmonary and Critical Care Division (R.K.P., A.A.M., G.R.W., G.M.H.), Dept of Radiology (R.S.J.E.), and Channing Division of Network Medicine (M.H.C., E.K.S.), Brigham and Women's Hospital and Harvard Medical School, Boston, Mass; Dept of Radiology, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan (A.H., M.Y., N.T.); Dept of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan (T. Hida, H. Honda, K.I.); Dept of Radiology, Kansai Medical University, Hirakata, Japan (O.H.); Dept of Radiology, Keio University School of Medicine, Tokyo, Japan (Y.Y., M.J.); Dept of Radiology, Hospital of the University of Pennsylvania, Philadelphia, Pa (T.A.); Dept of Radiology, Kansai Rosai Hospital, Amagasaki, Japan (T.J.); Dept of Environmental Health, Harvard TH Chan School of Public Health, Boston, Mass (D.C.C.); and Dept of Radiology, National Jewish Health, Denver, Colo (D.A.L.).

Takeshi Johkoh (T)

From the Ctr for Pulmonary Functional Imaging, Dept of Radiology (A.H., T. Hino, T. Hida, M.N., V.I.V., G.M.H., H. Hatabu), Pulmonary and Critical Care Division (R.K.P., A.A.M., G.R.W., G.M.H.), Dept of Radiology (R.S.J.E.), and Channing Division of Network Medicine (M.H.C., E.K.S.), Brigham and Women's Hospital and Harvard Medical School, Boston, Mass; Dept of Radiology, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan (A.H., M.Y., N.T.); Dept of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan (T. Hida, H. Honda, K.I.); Dept of Radiology, Kansai Medical University, Hirakata, Japan (O.H.); Dept of Radiology, Keio University School of Medicine, Tokyo, Japan (Y.Y., M.J.); Dept of Radiology, Hospital of the University of Pennsylvania, Philadelphia, Pa (T.A.); Dept of Radiology, Kansai Rosai Hospital, Amagasaki, Japan (T.J.); Dept of Environmental Health, Harvard TH Chan School of Public Health, Boston, Mass (D.C.C.); and Dept of Radiology, National Jewish Health, Denver, Colo (D.A.L.).

Noriyuki Tomiyama (N)

From the Ctr for Pulmonary Functional Imaging, Dept of Radiology (A.H., T. Hino, T. Hida, M.N., V.I.V., G.M.H., H. Hatabu), Pulmonary and Critical Care Division (R.K.P., A.A.M., G.R.W., G.M.H.), Dept of Radiology (R.S.J.E.), and Channing Division of Network Medicine (M.H.C., E.K.S.), Brigham and Women's Hospital and Harvard Medical School, Boston, Mass; Dept of Radiology, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan (A.H., M.Y., N.T.); Dept of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan (T. Hida, H. Honda, K.I.); Dept of Radiology, Kansai Medical University, Hirakata, Japan (O.H.); Dept of Radiology, Keio University School of Medicine, Tokyo, Japan (Y.Y., M.J.); Dept of Radiology, Hospital of the University of Pennsylvania, Philadelphia, Pa (T.A.); Dept of Radiology, Kansai Rosai Hospital, Amagasaki, Japan (T.J.); Dept of Environmental Health, Harvard TH Chan School of Public Health, Boston, Mass (D.C.C.); and Dept of Radiology, National Jewish Health, Denver, Colo (D.A.L.).

David C Christiani (DC)

From the Ctr for Pulmonary Functional Imaging, Dept of Radiology (A.H., T. Hino, T. Hida, M.N., V.I.V., G.M.H., H. Hatabu), Pulmonary and Critical Care Division (R.K.P., A.A.M., G.R.W., G.M.H.), Dept of Radiology (R.S.J.E.), and Channing Division of Network Medicine (M.H.C., E.K.S.), Brigham and Women's Hospital and Harvard Medical School, Boston, Mass; Dept of Radiology, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan (A.H., M.Y., N.T.); Dept of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan (T. Hida, H. Honda, K.I.); Dept of Radiology, Kansai Medical University, Hirakata, Japan (O.H.); Dept of Radiology, Keio University School of Medicine, Tokyo, Japan (Y.Y., M.J.); Dept of Radiology, Hospital of the University of Pennsylvania, Philadelphia, Pa (T.A.); Dept of Radiology, Kansai Rosai Hospital, Amagasaki, Japan (T.J.); Dept of Environmental Health, Harvard TH Chan School of Public Health, Boston, Mass (D.C.C.); and Dept of Radiology, National Jewish Health, Denver, Colo (D.A.L.).

David A Lynch (DA)

From the Ctr for Pulmonary Functional Imaging, Dept of Radiology (A.H., T. Hino, T. Hida, M.N., V.I.V., G.M.H., H. Hatabu), Pulmonary and Critical Care Division (R.K.P., A.A.M., G.R.W., G.M.H.), Dept of Radiology (R.S.J.E.), and Channing Division of Network Medicine (M.H.C., E.K.S.), Brigham and Women's Hospital and Harvard Medical School, Boston, Mass; Dept of Radiology, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan (A.H., M.Y., N.T.); Dept of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan (T. Hida, H. Honda, K.I.); Dept of Radiology, Kansai Medical University, Hirakata, Japan (O.H.); Dept of Radiology, Keio University School of Medicine, Tokyo, Japan (Y.Y., M.J.); Dept of Radiology, Hospital of the University of Pennsylvania, Philadelphia, Pa (T.A.); Dept of Radiology, Kansai Rosai Hospital, Amagasaki, Japan (T.J.); Dept of Environmental Health, Harvard TH Chan School of Public Health, Boston, Mass (D.C.C.); and Dept of Radiology, National Jewish Health, Denver, Colo (D.A.L.).

Raúl San José Estépar (R)

From the Ctr for Pulmonary Functional Imaging, Dept of Radiology (A.H., T. Hino, T. Hida, M.N., V.I.V., G.M.H., H. Hatabu), Pulmonary and Critical Care Division (R.K.P., A.A.M., G.R.W., G.M.H.), Dept of Radiology (R.S.J.E.), and Channing Division of Network Medicine (M.H.C., E.K.S.), Brigham and Women's Hospital and Harvard Medical School, Boston, Mass; Dept of Radiology, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan (A.H., M.Y., N.T.); Dept of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan (T. Hida, H. Honda, K.I.); Dept of Radiology, Kansai Medical University, Hirakata, Japan (O.H.); Dept of Radiology, Keio University School of Medicine, Tokyo, Japan (Y.Y., M.J.); Dept of Radiology, Hospital of the University of Pennsylvania, Philadelphia, Pa (T.A.); Dept of Radiology, Kansai Rosai Hospital, Amagasaki, Japan (T.J.); Dept of Environmental Health, Harvard TH Chan School of Public Health, Boston, Mass (D.C.C.); and Dept of Radiology, National Jewish Health, Denver, Colo (D.A.L.).

George R Washko (GR)

From the Ctr for Pulmonary Functional Imaging, Dept of Radiology (A.H., T. Hino, T. Hida, M.N., V.I.V., G.M.H., H. Hatabu), Pulmonary and Critical Care Division (R.K.P., A.A.M., G.R.W., G.M.H.), Dept of Radiology (R.S.J.E.), and Channing Division of Network Medicine (M.H.C., E.K.S.), Brigham and Women's Hospital and Harvard Medical School, Boston, Mass; Dept of Radiology, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan (A.H., M.Y., N.T.); Dept of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan (T. Hida, H. Honda, K.I.); Dept of Radiology, Kansai Medical University, Hirakata, Japan (O.H.); Dept of Radiology, Keio University School of Medicine, Tokyo, Japan (Y.Y., M.J.); Dept of Radiology, Hospital of the University of Pennsylvania, Philadelphia, Pa (T.A.); Dept of Radiology, Kansai Rosai Hospital, Amagasaki, Japan (T.J.); Dept of Environmental Health, Harvard TH Chan School of Public Health, Boston, Mass (D.C.C.); and Dept of Radiology, National Jewish Health, Denver, Colo (D.A.L.).

Michael H Cho (MH)

From the Ctr for Pulmonary Functional Imaging, Dept of Radiology (A.H., T. Hino, T. Hida, M.N., V.I.V., G.M.H., H. Hatabu), Pulmonary and Critical Care Division (R.K.P., A.A.M., G.R.W., G.M.H.), Dept of Radiology (R.S.J.E.), and Channing Division of Network Medicine (M.H.C., E.K.S.), Brigham and Women's Hospital and Harvard Medical School, Boston, Mass; Dept of Radiology, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan (A.H., M.Y., N.T.); Dept of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan (T. Hida, H. Honda, K.I.); Dept of Radiology, Kansai Medical University, Hirakata, Japan (O.H.); Dept of Radiology, Keio University School of Medicine, Tokyo, Japan (Y.Y., M.J.); Dept of Radiology, Hospital of the University of Pennsylvania, Philadelphia, Pa (T.A.); Dept of Radiology, Kansai Rosai Hospital, Amagasaki, Japan (T.J.); Dept of Environmental Health, Harvard TH Chan School of Public Health, Boston, Mass (D.C.C.); and Dept of Radiology, National Jewish Health, Denver, Colo (D.A.L.).

Edwin K Silverman (EK)

From the Ctr for Pulmonary Functional Imaging, Dept of Radiology (A.H., T. Hino, T. Hida, M.N., V.I.V., G.M.H., H. Hatabu), Pulmonary and Critical Care Division (R.K.P., A.A.M., G.R.W., G.M.H.), Dept of Radiology (R.S.J.E.), and Channing Division of Network Medicine (M.H.C., E.K.S.), Brigham and Women's Hospital and Harvard Medical School, Boston, Mass; Dept of Radiology, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan (A.H., M.Y., N.T.); Dept of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan (T. Hida, H. Honda, K.I.); Dept of Radiology, Kansai Medical University, Hirakata, Japan (O.H.); Dept of Radiology, Keio University School of Medicine, Tokyo, Japan (Y.Y., M.J.); Dept of Radiology, Hospital of the University of Pennsylvania, Philadelphia, Pa (T.A.); Dept of Radiology, Kansai Rosai Hospital, Amagasaki, Japan (T.J.); Dept of Environmental Health, Harvard TH Chan School of Public Health, Boston, Mass (D.C.C.); and Dept of Radiology, National Jewish Health, Denver, Colo (D.A.L.).

Gary M Hunninghake (GM)

From the Ctr for Pulmonary Functional Imaging, Dept of Radiology (A.H., T. Hino, T. Hida, M.N., V.I.V., G.M.H., H. Hatabu), Pulmonary and Critical Care Division (R.K.P., A.A.M., G.R.W., G.M.H.), Dept of Radiology (R.S.J.E.), and Channing Division of Network Medicine (M.H.C., E.K.S.), Brigham and Women's Hospital and Harvard Medical School, Boston, Mass; Dept of Radiology, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan (A.H., M.Y., N.T.); Dept of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan (T. Hida, H. Honda, K.I.); Dept of Radiology, Kansai Medical University, Hirakata, Japan (O.H.); Dept of Radiology, Keio University School of Medicine, Tokyo, Japan (Y.Y., M.J.); Dept of Radiology, Hospital of the University of Pennsylvania, Philadelphia, Pa (T.A.); Dept of Radiology, Kansai Rosai Hospital, Amagasaki, Japan (T.J.); Dept of Environmental Health, Harvard TH Chan School of Public Health, Boston, Mass (D.C.C.); and Dept of Radiology, National Jewish Health, Denver, Colo (D.A.L.).

Hiroto Hatabu (H)

From the Ctr for Pulmonary Functional Imaging, Dept of Radiology (A.H., T. Hino, T. Hida, M.N., V.I.V., G.M.H., H. Hatabu), Pulmonary and Critical Care Division (R.K.P., A.A.M., G.R.W., G.M.H.), Dept of Radiology (R.S.J.E.), and Channing Division of Network Medicine (M.H.C., E.K.S.), Brigham and Women's Hospital and Harvard Medical School, Boston, Mass; Dept of Radiology, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan (A.H., M.Y., N.T.); Dept of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan (T. Hida, H. Honda, K.I.); Dept of Radiology, Kansai Medical University, Hirakata, Japan (O.H.); Dept of Radiology, Keio University School of Medicine, Tokyo, Japan (Y.Y., M.J.); Dept of Radiology, Hospital of the University of Pennsylvania, Philadelphia, Pa (T.A.); Dept of Radiology, Kansai Rosai Hospital, Amagasaki, Japan (T.J.); Dept of Environmental Health, Harvard TH Chan School of Public Health, Boston, Mass (D.C.C.); and Dept of Radiology, National Jewish Health, Denver, Colo (D.A.L.).
From the Ctr for Pulmonary Functional Imaging, Dept of Radiology (A.H., T. Hino, T. Hida, M.N., V.I.V., G.M.H., H. Hatabu), Pulmonary and Critical Care Division (R.K.P., A.A.M., G.R.W., G.M.H.), Dept of Radiology (R.S.J.E.), and Channing Division of Network Medicine (M.H.C., E.K.S.), Brigham and Women's Hospital and Harvard Medical School, Boston, Mass; Dept of Radiology, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan (A.H., M.Y., N.T.); Dept of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan (T. Hida, H. Honda, K.I.); Dept of Radiology, Kansai Medical University, Hirakata, Japan (O.H.); Dept of Radiology, Keio University School of Medicine, Tokyo, Japan (Y.Y., M.J.); Dept of Radiology, Hospital of the University of Pennsylvania, Philadelphia, Pa (T.A.); Dept of Radiology, Kansai Rosai Hospital, Amagasaki, Japan (T.J.); Dept of Environmental Health, Harvard TH Chan School of Public Health, Boston, Mass (D.C.C.); and Dept of Radiology, National Jewish Health, Denver, Colo (D.A.L.).

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