Synthetically trained convolutional neural networks for improved tensor estimation from free-breathing cardiac DTI.

Cardiac diffusion tensor imaging (cDTI) provides invaluable information about the state of myocardial microstructure. For further clinical dissemination, free-breathing acquisitions are desired, which however require image registration prior to tensor estimation. Due to the varying contrast and the intrinsically low signal-to-noise ratio (SNR), registration is very challenging and thus can introduce additional errors in the tensor estimation. In the work at hand it is hypothesized, that by incorporating spatial information and physiologically plausible priors into the fitting algorithm, the robustness of diffusion tensor estimation can be improved. To this end, we present a parameterized pipeline to generate synthetic data, that captures the statistics including spatial correlations of diffusion tensors and motion of the heart. The synthetic data is used to train a residual convolutional neural network (CNN) to estimate diffusion tensors from unregistered in-vivo cDTI data. Using in-silico data, the synthetically trained CNN is demonstrated to yield increased tensor estimation accuracy and precision when compared to conventional registration followed by least squares fitting. The network outputs fewer outliers especially at the myocardial borders. In-vivo feasibility using data from five healthy subjects demonstrates the utility of the synthetically trained network. The in-vivo results predicted by the synthetically trained CNN are found to be consistent with the registered least-squares estimates while showing fewer outliers and reduced noise. Even in low SNR regimes, the network results in robust tensor estimation, enabling scan time reduction by reduced-average acquisition in-vivo. Finally, to investigate the network's capability of discriminating between healthy and lesioned tissue, the in-vivo data was artificially augmented showing preserved classification of tissue states based on diffusion metrics.

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