Epidemiological and genomic findings of the first documented Italian outbreak of SARS-CoV-2 Alpha variant of concern.
Abruzzo
Epidemiology
Genomic surveillance
Reproduction number
SARS-CoV-2, Alpha variant
Journal
Epidemics
ISSN: 1878-0067
Titre abrégé: Epidemics
Pays: Netherlands
ID NLM: 101484711
Informations de publication
Date de publication:
06 2022
06 2022
Historique:
received:
17
09
2021
revised:
14
04
2022
accepted:
09
05
2022
pubmed:
1
6
2022
medline:
16
6
2022
entrez:
31
5
2022
Statut:
ppublish
Résumé
From 24 December 2020 to 8 February 2021, 163 cases of SARS-CoV-2 Alpha variant of concern (VOC) were identified in Chieti province, Abruzzo region. Epidemiological data allowed the identification of 14 epi-clusters. With one exception, all the epi-clusters were linked to the town of Guardiagrele: 149 contacts formed the network, two-thirds of which were referred to the family/friends context. Real data were then used to estimate transmission parameters. According to our method, the calculated Re(t) was higher than 2 before the 12 December 2020. Similar values were obtained from other studies considering Alpha VOC. Italian sequence data were combined with a random subset of sequences obtained from the GISAID database. Genomic analysis showed close identity between the sequences from Guardiagrele, forming one distinct clade. This would suggest one or limited unspecified viral introductions from outside to Abruzzo region in early December 2020, which led to the diffusion of Alpha VOC in Guardiagrele and in neighbouring municipalities, with very limited inter-regional mixing.
Identifiants
pubmed: 35636310
pii: S1755-4365(22)00028-7
doi: 10.1016/j.epidem.2022.100578
pmc: PMC9098518
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
100578Informations de copyright
Copyright © 2022 The Authors. Published by Elsevier B.V. All rights reserved.
Références
PLoS One. 2020 Nov 11;15(11):e0242128
pubmed: 33175914
Microorganisms. 2020 Jun 16;8(6):
pubmed: 32560207
Emerg Microbes Infect. 2021 Dec;10(1):1148-1155
pubmed: 34019466
Clin Infect Dis. 2022 Mar 1;74(4):703-706
pubmed: 34105720
Am J Epidemiol. 2012 Aug 1;176(3):196-203
pubmed: 22791742
One Health. 2020 Apr 19;10:100135
pubmed: 32313828
PLoS Comput Biol. 2020 Dec 10;16(12):e1008409
pubmed: 33301457
Epidemics. 2019 Dec;29:100356
pubmed: 31624039
BMJ Open. 2020 Nov 23;10(11):e040263
pubmed: 33234640
Int J Infect Dis. 2021 Apr;105:753-755
pubmed: 33684558
Nature. 2021 May;593(7858):270-274
pubmed: 33723411
Philos Trans R Soc Lond B Biol Sci. 2021 Jul 19;376(1829):20200283
pubmed: 34053260
Nature. 2021 May;593(7858):266-269
pubmed: 33767447
Am J Epidemiol. 2013 Nov 1;178(9):1505-12
pubmed: 24043437
Science. 2021 Mar 12;371(6534):1152-1153
pubmed: 33514629
Microorganisms. 2020 Jul 26;8(8):
pubmed: 32722621
Viruses. 2020 Dec 14;12(12):
pubmed: 33327566
Science. 2021 Apr 9;372(6538):
pubmed: 33658326
Microorganisms. 2020 Oct 31;8(11):
pubmed: 33142840
Epidemics. 2021 Dec;37:100480
pubmed: 34488035
Wellcome Open Res. 2021 May 19;6:121
pubmed: 34095513
Lancet Infect Dis. 2021 Nov;21(11):1507-1517
pubmed: 34171231