Impact of Positive Lymph Nodes and Resection Margin Status on the Overall Survival of Patients with Resected Perihilar Cholangiocarcinoma: The ENSCCA Registry.
lymph nodes
overall survival
perihilar cholangiocarcinoma
recurrence-free survival
resection margin
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
12 May 2022
12 May 2022
Historique:
received:
25
03
2022
revised:
09
05
2022
accepted:
10
05
2022
entrez:
28
5
2022
pubmed:
29
5
2022
medline:
29
5
2022
Statut:
epublish
Résumé
Background: Lymph node metastasis and positive resection margins have been reported to be major determinants of overall survival (OS) and poor recurrence-free survival (RFS) for patients who underwent resection for perihilar cholangiocarcinoma (pCCA). However, the prognostic value of positive lymph nodes independently from resection margin status on OS has not been evaluated. Methods: From the European Cholangiocarcinoma (ENSCCA) registry, patients who underwent resection for pCCA between 1994 and 2021 were included in this retrospective cohort study. The primary outcome was OS stratified for resection margin and lymph node status. The secondary outcome was recurrence-free survival. Results: A total of 325 patients from 11 different centers and six European countries were included. Of these, 194 (59.7%) patients had negative resection margins. In 113 (34.8%) patients, positive lymph nodes were found. Lymph node status, histological grade, and ECOG performance status were independent prognostic factors for survival. The median OS for N0R0, N0R1, N+R0, and N+R1 was 38, 30, 18, and 12 months, respectively (p < 0.001). Conclusion: These data indicate that in the presence of positive regional lymph nodes, resection margin status does not determine OS or RFS in patients with pCCA. Achieving negative margins in patients with positive nodes should not come at the expense of more extensive surgery and associated higher mortality.
Identifiants
pubmed: 35625993
pii: cancers14102389
doi: 10.3390/cancers14102389
pmc: PMC9140174
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : the European Association for the Study of the Liver (EASL; Registry grant awards 2016 and 2019 to JMB)
ID : grant awards 2016 and 2019
Organisme : Incyte Bioscience International Sàrl
ID : grant award 2020
Organisme : European Union's Horizon 2020 Research and Innovation Program
ID : 825510
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