Gender Differences in Medication Adverse Effects Experienced by People Living With Chronic Pain.
adverse effects
chronic pain
gender
sex
side effects
Journal
Frontiers in pain research (Lausanne, Switzerland)
ISSN: 2673-561X
Titre abrégé: Front Pain Res (Lausanne)
Pays: Switzerland
ID NLM: 9918227269806676
Informations de publication
Date de publication:
2022
2022
Historique:
received:
06
12
2021
accepted:
18
04
2022
entrez:
27
5
2022
pubmed:
28
5
2022
medline:
28
5
2022
Statut:
epublish
Résumé
Understanding gender differences in chronic pain (CP) outcome research is essential to optimal treatment delivery. This study explored the associations between gender identity, gender roles, and the number of non-life-threatening pain medication adverse effects reported as severe by people living with CP. The analyses were conducted using the COPE Cohort, a dataset generated through a web-based recruitment of adults with CP. Participants were asked how they identified themselves (women, men, unknown, unspecified) and gender roles were measured using the Bem Sex-Role Inventory (subgroups were formed applying the median split method). Pain medication adverse effects were assessed using a standardized checklist (none/mild/moderate/severe). A zero-inflated Poisson model was used to assess gender identity, gender roles and their interaction as potential predictors of the number of pain medication adverse effects. A total of 1,343 participants reported using pain medications. Adjusting for potential confounders, both gender identity (men vs. women: ß = -0.32, Although we are unable to confirm whether the associations can be explained by differences in the experience or in the reporting of effects, gender identity and gender roles should both be explored when studying pain medication adverse effects.
Identifiants
pubmed: 35620635
doi: 10.3389/fpain.2022.830153
pmc: PMC9128021
doi:
Types de publication
Journal Article
Langues
eng
Pagination
830153Informations de copyright
Copyright © 2022 Nguena Nguefack, Gabrielle Pagé, Guénette, Blais, Diallo, Godbout-Parent, Angarita-Fonseca and Lacasse.
Déclaration de conflit d'intérêts
AL holds a Junior 2 research scholarship from the FRQS in partnership with the Quebec SUPPORT Unit (Support for People and Patient-Oriented Research and Trials). MGP holds a Junior 1 research scholarship from the FRQS. MG-P and AA-F, respectively, hold Canadian Institutes of Health Research (CIHR) master's degree and FRQS postdoctoral scholarships. The Chronic Pain Epidemiology Laboratory led by AL was funded by the Fondation de l'Université du Québec en Abitibi-Témiscamingue (FUQAT), in partnership with local businesses: the Pharmacie Jean-Coutu de Rouyn-Noranda (community pharmacy) and Glencore Fonderie Horne (copper smelter). LB received research grants from AstraZeneca, TEVA and Genentech, as well as consultation fees from AstraZeneca, TEVA and Genentech for projects unrelated to this study. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
J Pain. 2009 May;10(5):447-85
pubmed: 19411059
Pain. 2011 Jun;152(6):1249-1255
pubmed: 21397401
Epidemiology (Sunnyvale). 2016 Apr;6(2):
pubmed: 27274911
Pilot Feasibility Stud. 2018 Jun 12;4:95
pubmed: 30026961
Can J Psychiatry. 2008 Apr;53(4):213-23
pubmed: 18478824
Ann Ist Super Sanita. 2016 Apr-Jun;52(2):184-9
pubmed: 27364392
Curr Med Res Opin. 2015;31(7):1403-11
pubmed: 25868712
Can J Anaesth. 2010 Jun;57(6):539-48
pubmed: 20393821
Pain Med. 2009 Jul;10 Suppl 2:S53-66
pubmed: 19691685
Pain Res Manag. 2017;2017:8123812
pubmed: 28280406
Eur J Anaesthesiol Suppl. 2002;26:5-15
pubmed: 12512211
Neuropsychopharmacology. 2019 Jan;44(1):140-154
pubmed: 30082889
Thorax. 2007 Mar;62(3):219-23
pubmed: 17105779
Res Integr Peer Rev. 2017 Sep 01;2:15
pubmed: 29451565
Ther Adv Musculoskelet Dis. 2011 Aug;3(4):179-90
pubmed: 22870477
J Consult Clin Psychol. 1974 Apr;42(2):155-62
pubmed: 4823550
Psychol Bull. 2007 Jul;133(4):581-624
pubmed: 17592957
Am J Psychiatry. 2000 Sep;157(9):1445-52
pubmed: 10964861
Pain. 2003 Dec;106(3):337-345
pubmed: 14659516
Pain. 2005 Jan;113(1-2):9-19
pubmed: 15621359
Annu Rev Stat Appl. 2017 Mar;4:283-315
pubmed: 28890906
Pain. 2019 Jan;160(1):19-27
pubmed: 30586067
Res Integr Peer Rev. 2016 May 03;1:2
pubmed: 29451543
Pain Res Manag. 2013 May-Jun;18(3):119-26
pubmed: 23748251
Pain Res Manag. 2015 Jan-Feb;20(1):23-8
pubmed: 25664538
Respir Med. 2007 Jun;101(6):1313-20
pubmed: 17113277
J Pain. 2005 Feb;6(2):116-24
pubmed: 15694878
Arch Public Health. 2012 Jun 07;70(1):12
pubmed: 22958224
PLoS One. 2019 Feb 6;14(2):e0210701
pubmed: 30726245
Pharm Pract (Granada). 2016 Jan-Mar;14(1):708
pubmed: 27011778
J Pain. 2014 Jun;15(6):569-85
pubmed: 24787228
Pharmacoepidemiol Drug Saf. 2021 Aug;30(8):1012-1026
pubmed: 33901339
Lancet. 2020 Aug 22;396(10250):565-582
pubmed: 32828189
Pain. 2005 Mar;114(1-2):29-36
pubmed: 15733628
Pain Med. 2006 Jan-Feb;7(1):25-9
pubmed: 16533193
CMAJ. 2019 Oct 28;191(43):E1189-E1193
pubmed: 31659059
Clin J Pain. 2008 Mar-Apr;24(3):192-8
pubmed: 18287823
Int J Equity Health. 2019 Dec 21;18(1):199
pubmed: 31864366
CMAJ Open. 2017 Mar 10;5(1):E237-E248
pubmed: 28401140
Handb Exp Pharmacol. 2012;(214):107-26
pubmed: 23027448
Womens Health (Lond). 2009 Jan;5(1):79-90
pubmed: 19102644
Arch Intern Med. 2012 May 28;172(10):781-8
pubmed: 22507695
Int Rev Neurobiol. 2008;83:1-10
pubmed: 18929073
Harefuah. 2014 Jul;153(7):380-4, 434
pubmed: 25189025
J Pain. 2008 Apr;9(4):373-9
pubmed: 18203665
Can J Psychiatry. 2013 Apr;58(4):233-9
pubmed: 23547647
Pain. 2018 Nov;159(11):2137-2141
pubmed: 29781962
J Pain. 2015 Sep;16(9):852-61
pubmed: 26080044
Endocrinol Metab Clin North Am. 2019 Jun;48(2):303-321
pubmed: 31027541
Br J Clin Pharmacol. 2008 Mar;65(3):407-17
pubmed: 17922886
J Sex Marital Ther. 1997 Fall;23(3):176-94
pubmed: 9292833
BMJ Open. 2013 May 03;3(5):
pubmed: 23645921
J Clin Epidemiol. 1994 Jul;47(7):731-7
pubmed: 7722586
J Epidemiol Community Health. 1999 Aug;53(8):503-9
pubmed: 10562870
Acta Anaesthesiol Scand. 2016 Apr;60(4):416-31
pubmed: 26860919
BMJ Open. 2021 Jun 30;11(6):e044157
pubmed: 34193479
Trials. 2009 Jun 03;10:37
pubmed: 19493350
Eur J Neurol. 2010 Sep;17(9):1113-e88
pubmed: 20402746
Support Care Cancer. 2012 Oct;20(10):2553-7
pubmed: 22270087
Int J Equity Health. 2009 May 06;8:14
pubmed: 19419579