Bioorganometallic Compounds as Novel Drug Targets against Schistosomiasis in Sub-Saharan Africa: An alternative to Praziquantel?
Bioorganometallic compounds
Praziquantel
Reactive oxygen species
Redox biology
Schistosoma mansoni
Schistosomiasis
Journal
Advanced pharmaceutical bulletin
ISSN: 2228-5881
Titre abrégé: Adv Pharm Bull
Pays: Iran
ID NLM: 101578021
Informations de publication
Date de publication:
Mar 2022
Mar 2022
Historique:
received:
03
08
2020
revised:
12
03
2021
accepted:
29
05
2021
entrez:
27
5
2022
pubmed:
28
5
2022
medline:
28
5
2022
Statut:
ppublish
Résumé
Human schistosomiasis is a disease that mostly plagues the destitute of various tropical and sub-tropical countries, particularly in sub-Saharan Africa (SSA) and South America. It has significant effects on various health and economic-related matters. Globally, the burden of schistosomiasis has been controlled with a single chemotherapeutic drug, praziquantel (PZQ), which has recently demonstrated several clinical issues, including its inability to destroy juvenile schistosome worms and drug resistance because of its extensive use. The use of organometallic moieties in biological and medicinal chemistry has developed greatly and has led to their use in various anti-cancer and anti-infectious agents. The abundance of a range of organometallic compounds that can cause damage to the parasite has received tremendous feedback, with many already at clinical trials. The distinct redox biology of the schistosome parasite is a vulnerable element to the survival of the worm and has steered attempts toward the use of redox-directed bioorganometallic compounds. Disruption of the schistosome redox homeostasis through organometallic ions provides a novel drug target that could be used in overcoming the drawbacks of the mainstream drug and one that could possibly bypass the emergence of drug resistance.
Identifiants
pubmed: 35620337
doi: 10.34172/apb.2022.029
pmc: PMC9106956
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
283-297Informations de copyright
©2022 The Authors.
Références
Tanzan J Health Res. 2010 Jan;12(1):86-99
pubmed: 20737834
Rev Obstet Gynecol. 2010 Winter;3(1):28-32
pubmed: 20508780
Int J Parasitol. 2001 Sep;31(11):1227-35
pubmed: 11513892
Antioxid Redox Signal. 2013 Sep 20;19(9):958-69
pubmed: 23198996
Trends Parasitol. 2004 Jul;20(7):340-6
pubmed: 15193566
Lancet Infect Dis. 2015 Aug;15(8):927-40
pubmed: 26004859
Infect Dis Poverty. 2017 Feb 20;6(1):42
pubmed: 28219412
Lancet. 2010 Jan 16;375(9710):239-47
pubmed: 20109925
Future Med Chem. 2015;7(6):821-30
pubmed: 25996072
Free Radic Biol Med. 2017 Jun;107:2-12
pubmed: 28363603
Afr Health Sci. 2019 Mar;19(1):1338-1345
pubmed: 31148959
Bioorg Med Chem. 2014 Jul 1;22(13):3239-44
pubmed: 24857776
Antimicrob Agents Chemother. 2009 Apr;53(4):1320-4
pubmed: 19171802
Am J Clin Nutr. 2000 Nov;72(5):1082-7
pubmed: 11063432
Braz J Infect Dis. 2015 Mar-Apr;19(2):196-205
pubmed: 25636189
Oxid Med Cell Longev. 2016;2016:2054650
pubmed: 26941887
Eur J Med Chem. 2014 Jun 23;81:289-300
pubmed: 24852276
Pharmaceuticals (Basel). 2018 Feb 05;11(1):
pubmed: 29401734
Dalton Trans. 2012 Jun 7;41(21):6350-8
pubmed: 22411216
Parasitol Res. 2012 Nov;111(5):1871-7
pubmed: 23052781
Int J Parasitol. 2017 Mar;47(4):171-183
pubmed: 28012717
Parasit Vectors. 2014 Sep 04;7:424
pubmed: 25190030
J Bacteriol. 2018 Aug 10;200(17):
pubmed: 29891640
Chimia (Aarau). 2015;69(7-8):442-6
pubmed: 26507597
Parasitology. 2001;123 Suppl:S211-28
pubmed: 11769285
Antimicrob Agents Chemother. 2016 Aug 22;60(9):5331-6
pubmed: 27324765
Antioxid Redox Signal. 2012 Aug 15;17(4):555-82
pubmed: 22122517
Curr Med Chem. 2005;12(10):1161-208
pubmed: 15892631
Pharmaceuticals (Basel). 2015 Apr 02;8(2):151-75
pubmed: 25850012
Curr Opin Infect Dis. 2008 Dec;21(6):659-67
pubmed: 18978535
PLoS One. 2012;7(2):e31456
pubmed: 22384025
J Mol Graph Model. 2009 Feb;27(6):665-75
pubmed: 19070522
Int J Parasitol. 2004 Mar 29;34(4):527-33
pubmed: 15013742
PLoS One. 2014 Aug 13;9(8):e104875
pubmed: 25119882
Clin Microbiol Rev. 1999 Jan;12(1):97-111
pubmed: 9880476
PLoS Med. 2007 Jun;4(6):e206
pubmed: 17579510
IUBMB Life. 2007 Apr-May;59(4-5):293-8
pubmed: 17505968
Int J Parasitol. 2005 Jan;35(1):1-9
pubmed: 15619510
Arch Biochem Biophys. 2004 Jan 1;421(1):54-60
pubmed: 14678784
Acta Trop. 2003 May;86(2-3):125-39
pubmed: 12745133
Future Med Chem. 2015;7(6):701-5
pubmed: 25996063
Lancet. 2014 Jun 28;383(9936):2253-64
pubmed: 24698483
J Biol Chem. 2001 Oct 5;276(40):36873-6
pubmed: 11500482
Int J Parasitol. 2015 Jul;45(8):505-16
pubmed: 25910674
Parasitology. 2003 Oct;127(Pt 4):349-56
pubmed: 14636021
J Egypt Natl Canc Inst. 2012 Dec;24(4):151-9
pubmed: 23159285
In Vivo. 1999 May-Jun;13(3):295-309
pubmed: 10459507
J Med Chem. 2013 Nov 27;56(22):9192-8
pubmed: 24219617
Pharmacol Ther. 1995;68(1):35-85
pubmed: 8604437
World J Surg Oncol. 2017 Aug 2;15(1):146
pubmed: 28768520
Biochim Biophys Acta. 2007 Feb;1773(2):93-104
pubmed: 17023064
PLoS Negl Trop Dis. 2016 Sep 09;10(9):e0004986
pubmed: 27611863
Biochem Biophys Res Commun. 2017 Jan 15;482(3):419-425
pubmed: 28212725
Curr Pharm Des. 2012;18(24):3539-66
pubmed: 22607146
Antioxid Redox Signal. 2008 Aug;10(8):1343-74
pubmed: 18522489
J Med Chem. 2012 Oct 25;55(20):8790-8
pubmed: 23005702
Microbiol Spectr. 2019 Jul;7(4):
pubmed: 31325285
J Biol Chem. 2006 Jun 23;281(25):17001-17010
pubmed: 16606626
Front Immunol. 2018 Dec 20;9:3042
pubmed: 30619372
Int J Parasitol Drugs Drug Resist. 2014 Jul 30;4(3):185-200
pubmed: 25516827
Mem Inst Oswaldo Cruz. 2011 Mar;106(2):153-7
pubmed: 21537673
Curr Pharm Des. 2012;18(24):3595-611
pubmed: 22607149
Acta Trop. 2000 Oct 23;77(1):41-51
pubmed: 10996119
Proc Natl Acad Sci U S A. 2008 Aug 19;105(33):11628-33
pubmed: 18687892
Trop Med Infect Dis. 2018 Dec 19;3(4):
pubmed: 30572592
Dalton Trans. 2012 Jun 7;41(21):6335-49
pubmed: 22362072
Parasit Vectors. 2015 Mar 13;8:156
pubmed: 25884172
Chem Rev. 2019 Jan 23;119(2):730-796
pubmed: 30507157
Int J Environ Res Public Health. 2016 Sep 30;13(10):
pubmed: 27706050
ACS Infect Dis. 2017 Sep 8;3(9):645-652
pubmed: 28686009
Lancet. 2019 Dec 14;394(10215):2126
pubmed: 31839179
Lancet. 2006 Sep 23;368(9541):1106-18
pubmed: 16997665
Bioorg Med Chem Lett. 2012 Jan 15;22(2):1103-6
pubmed: 22217873
PLoS One. 2016 Jul 05;11(7):e0158429
pubmed: 27380021
J Parasitol. 2009 Dec;95(6):1421-8
pubmed: 19604033
Curr Med Chem. 2006;13(6):711-27
pubmed: 16529561
Int J Colorectal Dis. 2007 Feb;22(2):175-81
pubmed: 16786317
BMC Infect Dis. 2019 Aug 22;19(1):734
pubmed: 31438865
Parasitology. 2009 Nov;136(13):1825-35
pubmed: 19281637
Parasitol Int. 2017 Aug;66(4):390-395
pubmed: 27238582
Clin Infect Dis. 2010 May 1;50(9):1205-13
pubmed: 20350194
Parasitology. 2009 Nov;136(13):1665-75
pubmed: 19814845
Am J Trop Med Hyg. 1999 Jun;60(6):932-5
pubmed: 10403323
PLoS Negl Trop Dis. 2009 Aug 18;3(8):e504
pubmed: 19688043
Antimicrob Agents Chemother. 2017 Apr 24;61(5):
pubmed: 28264841
Curr Opin Chem Biol. 2012 Apr;16(1-2):84-91
pubmed: 22366385
J Clin Invest. 2008 Apr;118(4):1311-21
pubmed: 18382743
J Org Chem. 1999 Apr 16;64(8):2683-2689
pubmed: 11674337
Int J Parasitol. 2006 May 31;36(6):625-32
pubmed: 16545816
PLoS Negl Trop Dis. 2009 Aug 25;3(8):e412
pubmed: 19707588
Infect Disord Drug Targets. 2019;19(4):337-349
pubmed: 30599112