Age- and sex-specific effects of a long-term lifestyle intervention on body weight and cardiometabolic health markers in adults with prediabetes: results from the diabetes prevention study PREVIEW.
Cardiovascular disease
Men
Middle-aged people
Obesity
Older people
Weight loss
Weight loss maintenance
Women
Young people
Journal
Diabetologia
ISSN: 1432-0428
Titre abrégé: Diabetologia
Pays: Germany
ID NLM: 0006777
Informations de publication
Date de publication:
08 2022
08 2022
Historique:
received:
18
01
2022
accepted:
31
03
2022
pubmed:
25
5
2022
medline:
19
7
2022
entrez:
24
5
2022
Statut:
ppublish
Résumé
Lifestyle interventions are the first-line treatment option for body weight and cardiometabolic health management. However, whether age groups or women and men respond differently to lifestyle interventions is under debate. We aimed to examine age- and sex-specific effects of a low-energy diet (LED) followed by a long-term lifestyle intervention on body weight, body composition and cardiometabolic health markers in adults with prediabetes (i.e. impaired fasting glucose and/or impaired glucose tolerance). This observational study used longitudinal data from 2223 overweight participants with prediabetes in the multicentre diabetes prevention study PREVIEW. The participants underwent a LED-induced rapid weight loss (WL) period followed by a 3 year lifestyle-based weight maintenance (WM) intervention. Changes in outcomes of interest in prespecified age (younger: 25-45 years; middle-aged: 46-54 years; older: 55-70 years) or sex (women and men) groups were compared. In total, 783 younger, 319 middle-aged and 1121 older adults and 1503 women and 720 men were included in the analysis. In the available case and complete case analyses, multivariable-adjusted linear mixed models showed that younger and older adults had similar weight loss after the LED, whereas older adults had greater sustained weight loss after the WM intervention (adjusted difference for older vs younger adults -1.25% [95% CI -1.92, -0.58], p<0.001). After the WM intervention, older adults lost more fat-free mass and bone mass and had smaller improvements in 2 h plasma glucose (adjusted difference for older vs younger adults 0.65 mmol/l [95% CI 0.50, 0.80], p<0.001) and systolic blood pressure (adjusted difference for older vs younger adults 2.57 mmHg [95% CI 1.37, 3.77], p<0.001) than younger adults. Older adults had smaller decreases in fasting and 2 h glucose, HbA Older adults benefited less from a lifestyle intervention in relation to body composition and cardiometabolic health markers than younger adults, despite greater sustained weight loss. Women benefited less from a LED followed by a lifestyle intervention in relation to body weight and body composition than men. Future interventions targeting older adults or women should take prevention of fat-free mass and bone mass loss into consideration. ClinicalTrials.gov NCT01777893.
Identifiants
pubmed: 35610522
doi: 10.1007/s00125-022-05716-3
pii: 10.1007/s00125-022-05716-3
pmc: PMC9283166
doi:
Substances chimiques
Biomarkers
0
Blood Glucose
0
Cholesterol, HDL
0
Cholesterol, LDL
0
Glucose
IY9XDZ35W2
Banques de données
ClinicalTrials.gov
['NCT01777893']
Types de publication
Journal Article
Observational Study
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1262-1277Subventions
Organisme : Department of Health
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
Pays : United Kingdom
Informations de copyright
© 2022. The Author(s).
Références
Global Burden of Disease Obesity Collaborators (2017) Health effects of overweight and obesity in 195 countries over 25 years. N Engl J Med 377(1):13–27. https://doi.org/10.1056/NEJMoa1614362
doi: 10.1056/NEJMoa1614362
Heymsfield SB, Wadden TA (2017) Mechanisms, pathophysiology, and Management of Obesity. N Engl J Med 376(15):1492. https://doi.org/10.1056/NEJMc1701944
doi: 10.1056/NEJMc1701944
pubmed: 28402780
Eckel RH, Jakicic JM, Ard JD et al (2014) 2013 AHA/ACC guideline on lifestyle management to reduce cardiovascular risk: a report of the American College of Cardiology/American Heart Association task force on practice guidelines. Circulation 129(25 Suppl 2):S76–S99. https://doi.org/10.1161/01.cir.0000437740.48606.d1
doi: 10.1161/01.cir.0000437740.48606.d1
pubmed: 24222015
American College of Cardiology/American Heart Association Task Force on Practice Guidelines, Obesity Expert Panel, 2013 (2014) Executive summary: guidelines (2013) for the management of overweight and obesity in adults: a report of the American College of Cardiology/American Heart Association task force on practice guidelines and the obesity society published by the obesity society and American college of cardiology/American heart association task force on practice guidelines. Based on a systematic review from the the obesity expert panel, 2013. Obesity (Silver Spring) 22(Suppl 2):S5–S39. https://doi.org/10.1002/oby.20821
Jensen MD, Ryan DH, Apovian CM et al (2014) 2013 AHA/ACC/TOS guideline for the management of overweight and obesity in adults: a report of the American College of Cardiology/American Heart Association task force on practice guidelines and the obesity society. J Am Coll Cardiol 63(25 Pt B):2985–3023. https://doi.org/10.1016/j.jacc.2013.11.004
doi: 10.1016/j.jacc.2013.11.004
pubmed: 24239920
American Diabetes Association (2016) 3. Foundations of care and comprehensive medical evaluation. Diabetes Care 39(Suppl 1):S23–S35. https://doi.org/10.2337/dc16-S006
doi: 10.2337/dc16-S006
Diabetes Prevention Program Outcomes Study Research G, Orchard TJ, Temprosa M et al (2013) Long-term effects of the diabetes prevention program interventions on cardiovascular risk factors: a report from the DPP outcomes study. Diabet Med 30(1):46–55. https://doi.org/10.1111/j.1464-5491.2012.03750.x
doi: 10.1111/j.1464-5491.2012.03750.x
Salas-Salvado J, Diaz-Lopez A, Ruiz-Canela M et al (2019) Effect of a lifestyle intervention program with energy-restricted Mediterranean diet and exercise on weight loss and cardiovascular risk factors: one-year results of the PREDIMED-plus trial. Diabetes Care 42(5):777–788. https://doi.org/10.2337/dc18-0836
doi: 10.2337/dc18-0836
pubmed: 30389673
Höchsmann C, Dorling JL, Martin CK et al (2021) Effects of a 2-year primary care lifestyle intervention on cardiometabolic risk factors: a cluster-randomized trial. Circulation 143(12):1202–1214
doi: 10.1161/CIRCULATIONAHA.120.051328
Wing RR, Bolin P, Brancati FL et al (2013) Cardiovascular effects of intensive lifestyle intervention in type 2 diabetes. N Engl J Med 369(2):145–154. https://doi.org/10.1056/NEJMoa1212914
doi: 10.1056/NEJMoa1212914
pubmed: 23796131
Waters DL, Ward AL, Villareal DT (2013) Weight loss in obese adults 65 years and older: a review of the controversy. Exp Gerontol 48(10):1054–1061
doi: 10.1016/j.exger.2013.02.005
Haywood C, Sumithran P (2019) Treatment of obesity in older persons-a systematic review. Obes Rev 20(4):588–598. https://doi.org/10.1111/obr.12815
doi: 10.1111/obr.12815
pubmed: 30645010
Espeland MA, Rejeski WJ, West DS et al (2013) Intensive weight loss intervention in older individuals: results from the action for health in diabetes type 2 diabetes mellitus trial. J Am Geriatr Soc 61(6):912–922. https://doi.org/10.1111/jgs.12271
doi: 10.1111/jgs.12271
pubmed: 23668423
pmcid: 4123658
Williams RL, Wood LG, Collins CE, Callister R (2015) Effectiveness of weight loss interventions--is there a difference between men and women: a systematic review. Obes Rev 16(2):171–186. https://doi.org/10.1111/obr.12241
doi: 10.1111/obr.12241
pubmed: 25494712
Christensen P, Meinert Larsen T, Westerterp-Plantenga M et al (2018) Men and women respond differently to rapid weight loss: metabolic outcomes of a multi-Centre intervention study after a low-energy diet in 2500 overweight, individuals with pre-diabetes (PREVIEW). Diabetes Obes Metab 20(12):2840–2851. https://doi.org/10.1111/dom.13466
doi: 10.1111/dom.13466
pubmed: 30088336
pmcid: 6282840
Jesuthasan A, Zhyzhneuskaya S, Peters C et al (2021) Sex differences in intraorgan fat levels and hepatic lipid metabolism: implications for cardiovascular health and remission of type 2 diabetes after dietary weight loss. Diabetologia. https://doi.org/10.1007/s00125-021-05583-4
Raben A, Vestentoft PS, Brand-Miller J et al (2020) PREVIEW-results from a 3-year randomised 2 x 2 factorial multinational trial investigating the role of protein, glycemic index and physical activity for prevention of type-2 diabetes. Diabetes Obes Metab 23:324–337. https://doi.org/10.1111/dom.14219
doi: 10.1111/dom.14219
pubmed: 33026154
pmcid: 8120810
Cai X, Zhang Y, Li M et al (2020) Association between prediabetes and risk of all cause mortality and cardiovascular disease: updated meta-analysis. BMJ 370:m2297
doi: 10.1136/bmj.m2297
Almourani R, Chinnakotla B, Patel R, Kurukulasuriya LR, Sowers J (2019) Diabetes and cardiovascular disease: an update. Curr Diab Rep 19(12):161. https://doi.org/10.1007/s11892-019-1239-x
doi: 10.1007/s11892-019-1239-x
pubmed: 31828525
Welsh C, Welsh P, Celis-Morales CA et al (2020) Glycated hemoglobin, prediabetes, and the links to cardiovascular disease: data from UK biobank. Diabetes Care 43(2):440–445. https://doi.org/10.2337/dc19-1683
doi: 10.2337/dc19-1683
pubmed: 31852727
Fogelholm M, Larsen TM, Westerterp-Plantenga M et al (2017) PREVIEW: prevention of diabetes through lifestyle intervention and population studies in Europe and around the world. Design, methods, and baseline participant description of an adult cohort enrolled into a three-year randomised clinical trial. Nutrients 9(6):632. https://doi.org/10.3390/nu9060632
doi: 10.3390/nu9060632
pmcid: 5490611
American Diabetes Association Professional Practice Committee (2022) 2. Classification and diagnosis of diabetes: standards of medical care in diabetes—2022. Diabetes Care 45(Suppl 1):S17–S38. https://doi.org/10.2337/dc22-S002
doi: 10.2337/dc22-S002
Dyussenbayev A (2017) Age periods of human life. Adv Soc Sci Res J 4(6):258–263. https://doi.org/10.14738/assrj.46.2924
doi: 10.14738/assrj.46.2924
Zhu D, Chung H-F, Dobson AJ et al (2019) Age at natural menopause and risk of incident cardiovascular disease: a pooled analysis of individual patient data. Lancet Public Health 4(11):e553–e564
doi: 10.1016/S2468-2667(19)30155-0
Kahlert D, Unyi-Reicherz A, Stratton G et al (2016) PREVIEW behavior modification intervention toolbox (PREMIT): a study protocol for a psychological element of a multicenter project. Front Psychol 7:1136. https://doi.org/10.3389/fpsyg.2016.01136
doi: 10.3389/fpsyg.2016.01136
pubmed: 27559319
pmcid: 4978707
World Health Organization (2006) Definition and Diagnosis of Diabetes Mellitus and Intermediate Hyperglycaemia. Available from www.who.int/diabetes/publications/diagnosis_diabetes2006/en/ . Accessed July 19 2017.
Duncan MS, Freiberg MS, Greevy RA Jr, Kundu S, Vasan RS, Tindle HA (2019) Association of smoking cessation with subsequent risk of cardiovascular disease. JAMA 322(7):642–650. https://doi.org/10.1001/jama.2019.10298
doi: 10.1001/jama.2019.10298
pubmed: 31429895
pmcid: 6704757
Chiva-Blanch G, Badimon L (2020) Benefits and risks of moderate alcohol consumption on cardiovascular disease: current findings and controversies. Nutrients 12(1):108. https://doi.org/10.3390/nu12010108
doi: 10.3390/nu12010108
Malik MO, Govan L, Petrie JR et al (2015) Ethnicity and risk of cardiovascular disease (CVD): 4.8 year follow-up of patients with type 2 diabetes living in Scotland. Diabetologia 58(4):716–725. https://doi.org/10.1007/s00125-015-3492-0
doi: 10.1007/s00125-015-3492-0
pubmed: 25669630
Barbaresko J, Rienks J, Nothlings U (2018) Lifestyle indices and cardiovascular disease risk: a Meta-analysis. Am J Prev Med 55(4):555–564. https://doi.org/10.1016/j.amepre.2018.04.046
doi: 10.1016/j.amepre.2018.04.046
pubmed: 30241617
Mau T, Yung R (2018) Adipose tissue inflammation in aging. Exp Gerontol 105:27–31
doi: 10.1016/j.exger.2017.10.014
Lovejoy JC, Sainsbury A, Stock Conference Working G (2009) Sex differences in obesity and the regulation of energy homeostasis. Obes Rev 10(2):154–167. https://doi.org/10.1111/j.1467-789X.2008.00529.x
doi: 10.1111/j.1467-789X.2008.00529.x
pubmed: 19021872
Kologrivova IV, Vinnitskaya IV, Koshelskaya OA, Suslova TE (2017) Visceral obesity and cardiometabolic risk: features of hormonal and immune regulation. Obes Metab 14(3):3–10
doi: 10.14341/omet201733-10
Arpón A, Milagro FI, Santos JL, García-Granero M, Riezu-Boj J-I, Martínez JA (2019) Interaction among sex, aging, and epigenetic processes concerning visceral fat, insulin resistance, and dyslipidaemia. Front Endocrinol 10:496
doi: 10.3389/fendo.2019.00496
Svetkey LP, Clark JM, Funk K et al (2014) Greater weight loss with increasing age in the weight loss maintenance trial. Obesity (Silver Spring) 22(1):39–44. https://doi.org/10.1002/oby.20506
doi: 10.1002/oby.20506
Brokaw SM, Carpenedo D, Campbell P et al (2015) Effectiveness of an adapted diabetes prevention program lifestyle intervention in older and younger adults. J Am Geriatr Soc 63(6):1067–1074. https://doi.org/10.1111/jgs.13428
doi: 10.1111/jgs.13428
pubmed: 26031428
Armamento-Villareal R, Aguirre L, Waters DL, Napoli N, Qualls C, Villareal DT (2020) Effect of aerobic or resistance exercise, or both, on bone mineral density and bone metabolism in obese older adults while dieting: a randomized controlled trial. J Bone Miner Res 35(3):430–439. https://doi.org/10.1002/jbmr.3905
doi: 10.1002/jbmr.3905
pubmed: 31797417
Pinheiro MB, Oliveira J, Bauman A, Fairhall N, Kwok W, Sherrington C (2020) Evidence on physical activity and osteoporosis prevention for people aged 65+ years: a systematic review to inform the WHO guidelines on physical activity and sedentary behaviour. Int J Behav Nutr Phys Act 17(1):150. https://doi.org/10.1186/s12966-020-01040-4
doi: 10.1186/s12966-020-01040-4
pubmed: 33239014
pmcid: 7690138
Weinheimer EM, Sands LP, Campbell WW (2010) A systematic review of the separate and combined effects of energy restriction and exercise on fat-free mass in middle-aged and older adults: implications for sarcopenic obesity. Nutr Rev 68(7):375–388. https://doi.org/10.1111/j.1753-4887.2010.00298.x
doi: 10.1111/j.1753-4887.2010.00298.x
pubmed: 20591106
Wing RR, Espeland MA, Clark JM et al (2016) Association of weight loss maintenance and weight regain on 4-year changes in CVD risk factors: the action for health in diabetes (look AHEAD) clinical trial. Diabetes Care 39(8):1345–1355. https://doi.org/10.2337/dc16-0509
doi: 10.2337/dc16-0509
pubmed: 27271190
Berger SE, Huggins GS, McCaffery JM, Jacques PF, Lichtenstein AH (2019) Change in cardiometabolic risk factors associated with magnitude of weight regain 3 years after a 1-year intensive lifestyle intervention in type 2 diabetes mellitus: the look AHEAD trial. J Am Heart Assoc 8(20):e010951. https://doi.org/10.1161/JAHA.118.010951
doi: 10.1161/JAHA.118.010951
pubmed: 31594431
pmcid: 6818027
Wing RR, Lang W, Wadden TA et al (2011) Benefits of modest weight loss in improving cardiovascular risk factors in overweight and obese individuals with type 2 diabetes. Diabetes Care 34(7):1481–1486. https://doi.org/10.2337/dc10-2415
doi: 10.2337/dc10-2415
pubmed: 21593294
pmcid: 3120182
Slopien R, Wender-Ozegowska E, Rogowicz-Frontczak A et al (2018) Menopause and diabetes: EMAS clinical guide. Maturitas 117:6–10
doi: 10.1016/j.maturitas.2018.08.009
Robertson C, Avenell A, Boachie C et al (2016) Should weight loss and maintenance programmes be designed differently for men? A systematic review of long-term randomised controlled trials presenting data for men and women: the ROMEO project. Obes Res Clin Pract 10(1):70–84
doi: 10.1016/j.orcp.2015.04.005
Evans EM, Mojtahedi MC, Thorpe MP, Valentine RJ, Kris-Etherton PM, Layman DK (2012) Effects of protein intake and gender on body composition changes: a randomized clinical weight loss trial. Nutr Metab (Lond) 9(1):55. https://doi.org/10.1186/1743-7075-9-55
doi: 10.1186/1743-7075-9-55
Tirosh A, de Souza RJ, Sacks F, Bray GA, Smith SR, LeBoff MS (2015) Sex differences in the effects of weight loss diets on bone mineral density and body composition: POUNDS LOST trial. J Clin Endocrinol Metab 100(6):2463–2471. https://doi.org/10.1210/jc.2015-1050
doi: 10.1210/jc.2015-1050
pubmed: 25825948
pmcid: 4454797
Stiegler P, Cunliffe A (2006) The role of diet and exercise for the maintenance of fat-free mass and resting metabolic rate during weight loss. Sports Med 36(3):239–262. https://doi.org/10.2165/00007256-200636030-00005
doi: 10.2165/00007256-200636030-00005
pubmed: 16526835
Goossens GH, Jocken JWE, Blaak EE (2021) Sexual dimorphism in cardiometabolic health: the role of adipose tissue, muscle and liver. Nat Rev Endocrinol 17(1):47–66. https://doi.org/10.1038/s41574-020-00431-8
doi: 10.1038/s41574-020-00431-8
pubmed: 33173188
Perreault L, Ma Y, Dagogo-Jack S et al (2008) Sex differences in diabetes risk and the effect of intensive lifestyle modification in the diabetes prevention program. Diabetes Care 31(7):1416–1421. https://doi.org/10.2337/dc07-2390
doi: 10.2337/dc07-2390
pubmed: 18356403
pmcid: 2453677