Safety and immunogenicity of synchronous COVID19 and influenza vaccination.
COVID-19
HCW, healthcare workers
Healthcare workers
Influenzavirus
NPS, nasopharyngeal swab
SARS-CoV-2
Serology
VBT, vaccine breakthrough
Vaccination
Journal
Journal of clinical virology plus
ISSN: 2667-0380
Titre abrégé: J Clin Virol Plus
Pays: England
ID NLM: 9918283581506676
Informations de publication
Date de publication:
Aug 2022
Aug 2022
Historique:
received:
28
04
2022
accepted:
06
05
2022
entrez:
16
5
2022
pubmed:
17
5
2022
medline:
17
5
2022
Statut:
ppublish
Résumé
Given the ongoing COVID19 pandemic, the decline in serological response since dose 2, and the upcoming flu season, COVID19 vaccines will increasingly be administered in combination with vaccines against seasonal pathogens. It is of interest to confirm that concurrent vaccination against influenzavirus has no negative impact on serological response to SARS CoV-2. Anti-Spike IgG and Anti-Receptor Binding Domain (RBD) Neutralizing Antibodies (NAb) in serum was assessed in 64 immunocompetent healthcare workers (HCW) before and 14 days post the third dose of BNT162b2 vaccine (Comirnaty®, Pfizer/BioNTech) or BNT162b2 plus quadrivalent flu vaccine (Vaxigript Tetra ®Sanofi Pasteur) on the same day. We report here safety and efficacy of combined BNT162b2 and flu vaccine in 64 healthcare workers at a single institution. No differences were found in adverse events or anti-Spike antibody levels.
Identifiants
pubmed: 35571072
doi: 10.1016/j.jcvp.2022.100082
pii: S2667-0380(22)00021-7
pmc: PMC9077796
doi:
Types de publication
Journal Article
Langues
eng
Pagination
100082Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2022 The Authors.
Déclaration de conflit d'intérêts
We declare we have no conflict of interest related to this manuscript.
Références
Cell Res. 2021 Apr;31(4):395-403
pubmed: 33603116
Lancet. 2021 Dec 4;398(10316):2093-2100
pubmed: 34756184
Nat Med. 2021 Dec;27(12):2108-2110
pubmed: 34728830
JAMA. 2021 Dec 7;326(21):2203-2204
pubmed: 34739043
MMWR Recomm Rep. 2021 Aug 27;70(5):1-28
pubmed: 34448800