The Role of the Microbiota-Gut-Brain Axis in the Development of Alzheimer's Disease.
Alzheimer’s disease
microbiome
neuroinflammation
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
27 Apr 2022
27 Apr 2022
Historique:
received:
18
03
2022
revised:
16
04
2022
accepted:
21
04
2022
entrez:
14
5
2022
pubmed:
15
5
2022
medline:
18
5
2022
Statut:
epublish
Résumé
Along with the increase in life expectancy in the populations of developed and developing countries resulting from better access and improved health care, the number of patients with dementia, including Alzheimer's disease (AD), is growing. The disease was first diagnosed and described at the beginning of the 20th century. However, to this day, there is no effective causal therapy, and symptomatic treatment often improves patients' quality of life only for a short time. The current pharmacological therapies are based mainly on the oldest hypotheses of the disease-cholinergic (drugs affecting the cholinergic system are available), the hypothesis of amyloid-β aggregation (an anti-amyloid drug was conditionally approved by the FDA in 2020), and one drug is an N-methyl-D-aspartate receptor (NMDAR) antagonist (memantine). Hypotheses about AD pathogenesis focus on the nervous system and the brain. As research progresses, it has become known that AD can be caused by diseases that have been experienced over the course of a lifetime, which could also affect other organs. In this review, we focus on the potential association of AD with the digestive system, primarily the gut microbiota. The role of diet quality in preventing and alleviating Alzheimer's disease is also discussed. The problem of neuroinflammation, which may be the result of microbiota disorders, is also described. An important aspect of the work is the chapter on the treatment strategies for changing the microbiota, potentially protecting against the disease and alleviating its course in the initial stages.
Identifiants
pubmed: 35563253
pii: ijms23094862
doi: 10.3390/ijms23094862
pmc: PMC9104401
pii:
doi:
Substances chimiques
Cholinergic Agents
0
Receptors, N-Methyl-D-Aspartate
0
Memantine
W8O17SJF3T
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Références
Integr Med (Encinitas). 2014 Dec;13(6):17-22
pubmed: 26770121
Neuropsychiatr Dis Treat. 2020 Nov 13;16:2765-2777
pubmed: 33223831
Science. 2012 Jun 8;336(6086):1268-73
pubmed: 22674334
Pharmacol Res. 2018 Apr;130:331-365
pubmed: 29458203
Alzheimers Dement. 2016 Jun;12(6):719-32
pubmed: 27179961
Neuropsychiatr Dis Treat. 2021 May 04;17:1311-1339
pubmed: 33976546
Front Aging Neurosci. 2015 Feb 10;7:9
pubmed: 25713531
Biomed Pharmacother. 2022 May;149:112880
pubmed: 35367762
Sci Rep. 2017 Oct 19;7(1):13537
pubmed: 29051531
J Mol Biol. 2005 Sep 16;352(2):245-52
pubmed: 16083908
Adv Skin Wound Care. 2012 Jul;25(7):304-14
pubmed: 22713781
J Neuroinflammation. 2012 Jun 29;9:150
pubmed: 22747709
Oxid Med Cell Longev. 2021 Jul 8;2021:5525306
pubmed: 34306309
Curr Opin Gastroenterol. 2012 Nov;28(6):557-62
pubmed: 23010679
Arch Med Res. 2017 Nov;48(8):681-689
pubmed: 29229199
Front Aging Neurosci. 2018 Feb 22;10:42
pubmed: 29520228
Curr Neuropharmacol. 2013 Jul;11(4):338-78
pubmed: 24381528
J Gerontol A Biol Sci Med Sci. 2021 Jan 1;76(1):32-40
pubmed: 32300799
Front Neurol. 2018 Mar 19;9:145
pubmed: 29615954
Nutrients. 2018 Jul 12;10(7):
pubmed: 30002347
Int J Cell Biol. 2013;2013:576383
pubmed: 24223593
Mucosal Immunol. 2018 Sep;11(5):1386-1397
pubmed: 29867078
Sci Rep. 2021 Oct 19;11(1):20659
pubmed: 34667205
Nutrients. 2020 Jan 13;12(1):
pubmed: 31941117
Nutrients. 2021 Jun 19;13(6):
pubmed: 34205336
FASEB J. 2004 Jan;18(1):203-5
pubmed: 14597556
Int J Mol Sci. 2021 Mar 09;22(5):
pubmed: 33803217
J Neurochem. 2016 Feb;136(3):457-74
pubmed: 26509334
Maturitas. 2013 May;75(1):44-50
pubmed: 23489554
J Clin Immunol. 2014 Jul;34 Suppl 1:S64-9
pubmed: 24711006
J Psychopharmacol. 2021 Mar;35(3):265-272
pubmed: 33586518
Aging (Albany NY). 2020 Feb 15;12(4):4010-4039
pubmed: 32062613
J Alzheimers Dis. 2021;82(s1):S195-S214
pubmed: 33492296
Alzheimers Dement. 2015 Jan;11(1):51-7
pubmed: 24637300
Front Aging Neurosci. 2016 Nov 10;8:256
pubmed: 27891089
Mol Neurobiol. 2021 Apr;58(4):1453-1464
pubmed: 33188619
Clin Nutr. 2019 Dec;38(6):2569-2575
pubmed: 30642737
Front Immunol. 2017 Sep 04;8:1064
pubmed: 28928740
Nutrients. 2011 Jun;3(6):637-82
pubmed: 22254115
Am J Physiol Gastrointest Liver Physiol. 2012 Dec 1;303(11):G1288-95
pubmed: 23064760
Mol Neurobiol. 2019 Mar;56(3):1841-1851
pubmed: 29936690
Br J Pharmacol. 2015 Aug;172(15):3714-27
pubmed: 25939581
Curr Opin Clin Nutr Metab Care. 2016 Jan;19(1):12-8
pubmed: 26560524
Science. 2012 Jun 8;336(6086):1262-7
pubmed: 22674330
Neurosci Lett. 2016 Jun 20;625:56-63
pubmed: 26868600
Sci Transl Med. 2016 May 25;8(340):340ra72
pubmed: 27225182
Curr Opin Gastroenterol. 2016 Mar;32(2):96-102
pubmed: 26760398
PLoS One. 2016 Jan 05;11(1):e0144589
pubmed: 26731277
Curr Neuropharmacol. 2007 Dec;5(4):232-43
pubmed: 19305740
Front Aging Neurosci. 2017 Dec 12;9:407
pubmed: 29311897
Can J Gastroenterol Hepatol. 2019 Jan 17;2019:6757524
pubmed: 30792972
Cell Host Microbe. 2015 May 13;17(5):565-76
pubmed: 25974299
Semin Fetal Neonatal Med. 2016 Dec;21(6):410-417
pubmed: 27255860
Nat Rev Microbiol. 2012 Nov;10(11):735-42
pubmed: 23000955
Curr Rheumatol Rep. 2014 Mar;16(3):408
pubmed: 24458478
Front Pharmacol. 2019 May 22;10:540
pubmed: 31191302
Science. 2015 Dec 4;350(6265):1214-5
pubmed: 26785481
Protein Cell. 2017 Feb;8(2):90-102
pubmed: 27866330
Biofactors. 2020 Jan;46(1):5-20
pubmed: 31580521
Chem Biol Interact. 2008 Sep 25;175(1-3):222-6
pubmed: 18571635
Sci Rep. 2017 May 25;7(1):2426
pubmed: 28546539
Clin Transl Gastroenterol. 2016 Oct 20;7(10):e196
pubmed: 27763627
Behav Brain Res. 2015 Jan 15;277:32-48
pubmed: 25078296
Brain Behav Immun. 2021 Jul;95:330-343
pubmed: 33839232
Sci Rep. 2019 Jan 30;9(1):1008
pubmed: 30700769
Cells. 2021 Sep 09;10(9):
pubmed: 34572019
Eur J Med Chem. 2011 Aug;46(8):3250-7
pubmed: 21570751
Front Psychiatry. 2018 Nov 06;9:561
pubmed: 30459657
Neurobiol Stress. 2017 Mar 19;7:124-136
pubmed: 29276734
Neurobiol Aging. 2018 Oct;70:203-216
pubmed: 30031930
J Alzheimers Dis. 2016 Jun 27;53(4):1271-6
pubmed: 27372648
J Neurogastroenterol Motil. 2019 Jan 31;25(1):48-60
pubmed: 30646475
Microbiome. 2018 Mar 21;6(1):55
pubmed: 29562936
Neurobiol Aging. 2017 Jan;49:60-68
pubmed: 27776263
Neural Regen Res. 2021 Sep;16(9):1768-1769
pubmed: 33510069
Sci Adv. 2019 Jan 23;5(1):eaau3333
pubmed: 30746447
J Physiol. 2017 Jan 15;595(2):489-503
pubmed: 27641441
Biomed Res Int. 2020 May 24;2020:8456596
pubmed: 32596386
Mol Med Rep. 2020 Aug;22(2):1489-1497
pubmed: 32626959
Curr Neurol Neurosci Rep. 2017 Oct 17;17(12):94
pubmed: 29039142
Brain Behav Immun. 2021 Nov;98:357-365
pubmed: 34500036
Nutrients. 2021 May 11;13(5):
pubmed: 34064762
Eur J Med Chem. 2018 Jan 20;144:128-136
pubmed: 29268129
Alzheimers Res Ther. 2017 Mar 4;9(1):14
pubmed: 28259169
Brain Res. 2018 Aug 15;1693(Pt B):128-133
pubmed: 29903615
Nutrients. 2020 Sep 29;12(10):
pubmed: 33003412
Front Aging Neurosci. 2018 Apr 25;10:118
pubmed: 29922148
Pharmacol Biochem Behav. 2019 Oct;185:172760
pubmed: 31422081
J Nat Sci. 2015 Jul;1(7):
pubmed: 26097896
Biogerontology. 2020 Dec;21(6):807-815
pubmed: 32812166
Curr Opin Microbiol. 2013 Feb;16(1):93-9
pubmed: 23313395
Nutrients. 2018 Mar 27;10(4):
pubmed: 29584644
Sci Rep. 2016 Jul 21;6:30028
pubmed: 27443609
Neurology. 2017 Jun 13;88(24):2338
pubmed: 28607142
Sci Rep. 2017 Feb 08;7:41802
pubmed: 28176819
Alzheimers Dement. 2013 Mar;9(2):169-75
pubmed: 23159044
Eur J Clin Microbiol Infect Dis. 2014 Jul;33(7):1125-32
pubmed: 24452965
Front Microbiol. 2016 Sep 26;7:1544
pubmed: 27725817
J Neuroinflammation. 2011 Aug 09;8:92
pubmed: 21827663
Front Bioeng Biotechnol. 2020 Dec 14;8:537847
pubmed: 33384986
Curr Opin Pharmacol. 2012 Dec;12(6):667-72
pubmed: 23041079
Front Cell Infect Microbiol. 2017 Jul 11;7:318
pubmed: 28744452
J Am Geriatr Soc. 2010 Apr;58(4):713-8
pubmed: 20398152
Front Microbiol. 2018 May 07;9:890
pubmed: 29867803
Front Aging Neurosci. 2014 Jun 16;6:127
pubmed: 24982633
Front Cell Neurosci. 2013 Sep 17;7:153
pubmed: 24062644
Transl Res. 2017 Jan;179:223-244
pubmed: 27832936
J Alzheimers Dis. 2014;41(1):301-11
pubmed: 24614898
J Alzheimers Dis. 2017;56(2):775-788
pubmed: 28035935
Br J Nutr. 2017 Jun;117(12):1645-1655
pubmed: 28789729
PLoS One. 2010 Mar 03;5(3):e9505
pubmed: 20209079
Wiley Interdiscip Rev Syst Biol Med. 2013 Mar-Apr;5(2):153-80
pubmed: 22899644
J Alzheimers Dis. 2010;20(3):785-94
pubmed: 20182018
Int J Mol Sci. 2020 Apr 11;21(8):
pubmed: 32290475
Front Pharmacol. 2021 Jul 23;12:666502
pubmed: 34366841
Proc Natl Acad Sci U S A. 2011 Feb 15;108(7):3047-52
pubmed: 21282636
Trends Microbiol. 2012 Feb;20(2):66-73
pubmed: 22197327
J Alzheimers Dis. 2020;76(4):1199-1213
pubmed: 32597798