The effect of solution environment and the electrostatic factor on the crystallisation of desmotropes of irbesartan.
Journal
RSC advances
ISSN: 2046-2069
Titre abrégé: RSC Adv
Pays: England
ID NLM: 101581657
Informations de publication
Date de publication:
05 Feb 2019
05 Feb 2019
Historique:
received:
10
12
2018
accepted:
04
02
2019
entrez:
6
5
2022
pubmed:
11
2
2019
medline:
11
2
2019
Statut:
epublish
Résumé
The experimental conditions necessary for stabilising irbesartan (IBS) tautomers in solution and selectively obtaining the desmotropic crystal forms are presented herein. 1H and 2H tautomers were stabilized in specific solution conditions and the 2H-tetrazole⋯imidazole interaction was confirmed by solution-state NMR. The results showed that highly polar and polarisable solvents (higher values of the electrostatic factor (EF)) lead to the crystallisation of IBS form B. Furthermore, the variations of pH in methanol, in turn, determined the crystallisation of desmotropes A and/or B.
Identifiants
pubmed: 35514656
doi: 10.1039/c8ra10146a
pii: c8ra10146a
pmc: PMC9060688
doi:
Types de publication
Journal Article
Langues
eng
Pagination
5244-5250Informations de copyright
This journal is © The Royal Society of Chemistry.
Déclaration de conflit d'intérêts
There are no conflicts to declare.
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