Cerebrospinal fluid can exit into the skull bone marrow and instruct cranial hematopoiesis in mice with bacterial meningitis.

Animals Bone Marrow Brain / blood supply Cerebrospinal Fluid Glymphatic System / physiology Hematopoiesis Meningitis, Bacterial Mice Skull

Journal

Nature neuroscience
ISSN: 1546-1726
Titre abrégé: Nat Neurosci
Pays: United States
ID NLM: 9809671

Informations de publication

Date de publication:
05 2022
Historique:
received: 19 10 2021
accepted: 23 03 2022
pubmed: 3 5 2022
medline: 11 5 2022
entrez: 2 5 2022
Statut: ppublish

Résumé

Interactions between the immune and central nervous systems strongly influence brain health. Although the blood-brain barrier restricts this crosstalk, we now know that meningeal gateways through brain border tissues facilitate intersystem communication. Cerebrospinal fluid (CSF), which interfaces with the glymphatic system and thereby drains the brain's interstitial and perivascular spaces, facilitates outward signaling beyond the blood-brain barrier. In the present study, we report that CSF can exit into the skull bone marrow. Fluorescent tracers injected into the cisterna magna of mice migrate along perivascular spaces of dural blood vessels and then travel through hundreds of sub-millimeter skull channels into the calvarial marrow. During meningitis, bacteria hijack this route to invade the skull's hematopoietic niches and initiate cranial hematopoiesis ahead of remote tibial sites. As skull channels also directly provide leukocytes to meninges, the privileged sampling of brain-derived danger signals in CSF by regional marrow may have broad implications for inflammatory neurological disorders.

Identifiants

DOI: 10.1038/s41593-022-01060-2 PMID: 35501382 PMC: PMC9081225
pubmed: 35501382
doi: 10.1038/s41593-022-01060-2
pii: 10.1038/s41593-022-01060-2
pmc: PMC9081225
mid: NIHMS1792336
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

567-576

Subventions

Organisme : NINDS NIH HHS
ID : R01 NS108419
Pays : United States
Organisme : NHLBI NIH HHS
ID : R00 HL151750
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL125428
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL158534
Pays : United States
Organisme : NHLBI NIH HHS
ID : R35 HL135752
Pays : United States
Organisme : NHLBI NIH HHS
ID : P01 HL142494
Pays : United States
Organisme : NHLBI NIH HHS
ID : R35 HL139598
Pays : United States
Organisme : NHLBI NIH HHS
ID : F32 HL158040
Pays : United States
Organisme : NCI NIH HHS
ID : T32 CA079443
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK043351
Pays : United States

Commentaires et corrections

Type : CommentIn
Type : CommentIn

Informations de copyright

© 2022. The Author(s), under exclusive licence to Springer Nature America, Inc.

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Auteurs

Fadi E Pulous (FE)

Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
ORCID: 0000-0002-0794-8078

Jean C Cruz-Hernández (JC)

Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Wellman Center for Photomedicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

Chongbo Yang (C)

Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

Ζeynep Kaya (Ζ)

Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

Alexandre Paccalet (A)

Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
ORCID: 0000-0002-6331-562X

Gregory Wojtkiewicz (G)

Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
ORCID: 0000-0002-3148-8411

Diane Capen (D)

Program in Membrane Biology, Division of Nephrology, Department of Medicine, Harvard Medical School and Massachusetts General Hospital, Boston, MA, USA.

Dennis Brown (D)

Program in Membrane Biology, Division of Nephrology, Department of Medicine, Harvard Medical School and Massachusetts General Hospital, Boston, MA, USA.

Juwell W Wu (JW)

Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Wellman Center for Photomedicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

Maximilian J Schloss (MJ)

Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

Claudio Vinegoni (C)

Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
ORCID: 0000-0002-9818-3639

Dmitry Richter (D)

Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Wellman Center for Photomedicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

Masahiro Yamazoe (M)

Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

Maarten Hulsmans (M)

Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
ORCID: 0000-0003-1009-658X

Noor Momin (N)

Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

Jana Grune (J)

Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

David Rohde (D)

Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
ORCID: 0000-0002-3785-9375

Cameron S McAlpine (CS)

Cardiovascular Research Institute and Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Peter Panizzi (P)

Department of Drug Discovery and Development, Harrison School of Pharmacy, Auburn University, Auburn, AL, USA.

Ralph Weissleder (R)

Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

Dong-Eog Kim (DE)

Molecular Imaging and Neurovascular Research Laboratory, Department of Neurology, Dongguk University College of Medicine, Goyang, South Korea.

Filip K Swirski (FK)

Cardiovascular Research Institute and Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
ORCID: 0000-0002-3163-9152

Charles P Lin (CP)

Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. charles_lin@hms.harvard.edu.
Wellman Center for Photomedicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. charles_lin@hms.harvard.edu.
ORCID: 0000-0002-7450-627X

Michael A Moskowitz (MA)

Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. moskowitz@helix.mgh.harvard.edu.
Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. moskowitz@helix.mgh.harvard.edu.
Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. moskowitz@helix.mgh.harvard.edu.
ORCID: 0000-0002-9052-4937

Matthias Nahrendorf (M)

Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. mnahrendorf@mgh.harvard.edu.
Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. mnahrendorf@mgh.harvard.edu.
Cardiovascular Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. mnahrendorf@mgh.harvard.edu.
Department of Internal Medicine I, University Hospital Wuerzburg, Wuerzburg, Germany. mnahrendorf@mgh.harvard.edu.
ORCID: 0000-0002-4021-1887

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Classifications MeSH

Recherchemedicale.com › Eucaryotes › Animaux › Cerebrospinal fluid can exit into the skull...
Recherchemedicale.com › Systèmes sanguin et immunitaire › Système immunitaire › Moelle osseuse › Cerebrospinal fluid can exit into the skull...
Recherchemedicale.com › Système nerveux › Système nerveux central › Encéphale › Cerebrospinal fluid can exit into the skull...
Recherchemedicale.com › Liquides et sécrétions biologiques › Liquides biologiques › Liquide extracellulaire › Liquide cérébrospinal › Cerebrospinal fluid can exit into the skull...
Recherchemedicale.com › Systèmes sanguin et immunitaire › Système immunitaire › Système lymphatique › Système glymphatique › Cerebrospinal fluid can exit into the skull...
Recherchemedicale.com › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiogiques du sang › Hématopoïèse › Cerebrospinal fluid can exit into the skull...
Recherchemedicale.com › Maladies du système nerveux › Méningite › Méningite bactérienne › Cerebrospinal fluid can exit into the skull...
Recherchemedicale.com › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Cerebrospinal fluid can exit into the skull...
Recherchemedicale.com › Appareil locomoteur › Squelette › Crâne › Cerebrospinal fluid can exit into the skull...