Pronounced Orthostatic Hypotension in GBA-Related Parkinson's Disease.

Autonomic Nervous System Blood Pressure Glucosylceramidase / genetics Humans Hypotension, Orthostatic / etiology Mutation Parkinson Disease / complications
Autonomic symptoms GBA Parkinson’s disease orthostatic hypotension

Journal

Journal of Parkinson's disease
ISSN: 1877-718X
Titre abrégé: J Parkinsons Dis
Pays: Netherlands
ID NLM: 101567362

Informations de publication

Date de publication:
2022
Historique:
pubmed: 3 5 2022
medline: 14 7 2022
entrez: 2 5 2022
Statut: ppublish

Résumé

Patients with Parkinson's disease (PD) carrying variants in the Glucocerebrosidase (GBA) gene (GBA-PD) suffer from orthostatic symptoms more frequently than idiopathic PD patients (IPD). Systematic measurements of the blood pressure have not yet been performed. In the present study, a prospective analysis of 33 GBA-PD and 313 IPD patients was carried out. Systolic blood pressure upon changing from the supine to the upright position dropped more strongly in GBA-PD compared to IPD patients. Diastolic blood pressure and heart rate did not differ between groups. This study provides further evidence for a pronounced involvement of the autonomic nervous system in GBA-PD.

Identifiants

DOI: 10.3233/JPD-223197 PMID: 35491800
pubmed: 35491800
pii: JPD223197
doi: 10.3233/JPD-223197
doi:

Substances chimiques

Glucosylceramidase EC 3.2.1.45

Types de publication

Letter Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1539-1544

Auteurs

Tatiana Usnich (T)

Institute of Neurogenetics, University of Luebeck, Luebeck, Germany.

Henrike Hanssen (H)

Institute of Neurogenetics, University of Luebeck, Luebeck, Germany.
Department of Neurology, University of Luebeck, Luebeck, Germany.

Katja Lohmann (K)

Institute of Neurogenetics, University of Luebeck, Luebeck, Germany.

Christina Lohse (C)

Department of Neurology, University of Luebeck, Luebeck, Germany.

Christine Klein (C)

Institute of Neurogenetics, University of Luebeck, Luebeck, Germany.

Meike Kasten (M)

Institute of Neurogenetics, University of Luebeck, Luebeck, Germany.
Department of Psychiatry and Psychotherapy, University of Luebeck, Luebeck, Germany.

Norbert Brüggemann (N)

Institute of Neurogenetics, University of Luebeck, Luebeck, Germany.
Department of Neurology, University of Luebeck, Luebeck, Germany.

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Classifications MeSH

Recherchemedicale.com › Système nerveux › Système nerveux périphérique › Système nerveux autonome › Pronounced Orthostatic Hypotension in...
Recherchemedicale.com › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiologiques cardiovasculaires › Hémodynamique › Pression sanguine › Pronounced Orthostatic Hypotension in...
Recherchemedicale.com › Enzymes et coenzymes › Enzymes › Hydrolases › Glycosidases › Glucosidases › Glucosylceramidase › Pronounced Orthostatic Hypotension in...
Recherchemedicale.com › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Pronounced Orthostatic Hypotension in...
Recherchemedicale.com › Maladies cardiovasculaires › Maladies vasculaires › Hypotension artérielle › Hypotension orthostatique › Pronounced Orthostatic Hypotension in...
Recherchemedicale.com › Phénomènes génétiques › Variation génétique › Mutation › Pronounced Orthostatic Hypotension in...
Recherchemedicale.com › Maladies du système nerveux › Maladies neurodégénératives › Maladie de Parkinson › Pronounced Orthostatic Hypotension in...