Catastrophic DNA replication in unscheduled tetraploid cells.
cell cycle checkpoint
chromosomal instability
mitotic spindle
regulated cell death
replication stress
Journal
Trends in genetics : TIG
ISSN: 0168-9525
Titre abrégé: Trends Genet
Pays: England
ID NLM: 8507085
Informations de publication
Date de publication:
08 2022
08 2022
Historique:
received:
11
04
2022
accepted:
12
04
2022
pubmed:
1
5
2022
medline:
15
7
2022
entrez:
30
4
2022
Statut:
ppublish
Résumé
Unscheduled tetraploidy is a metastable state that rapidly evolves into aneuploidy. Recent findings reported by Gemble et al. demonstrate that freshly formed tetraploid cells fail to accumulate the required amounts of DNA replication factors during the first G
Identifiants
pubmed: 35490031
pii: S0168-9525(22)00085-3
doi: 10.1016/j.tig.2022.04.005
pii:
doi:
Substances chimiques
Cell Cycle Proteins
0
Types de publication
Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, Non-U.S. Gov't
Comment
Langues
eng
Sous-ensembles de citation
IM
Pagination
787-788Commentaires et corrections
Type : CommentOn
Informations de copyright
Copyright © 2022 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests L.G. has been holding research contracts with Lytix Biopharma and Phosplatin, has received consulting/advisory honoraria from Boehringer Ingelheim, AstraZeneca, OmniSEQ, Onxeo, The Longevity Labs, Inzen, Sotio, Phosplatin, Noxopharm, and the Luke Heller TECPR2 Foundation, and owns Phosplatin stock options. All other authors have no conflicts to declare.