Engineering cryoelectrospun elastin-alginate scaffolds to serve as stromal extracellular matrices.
3D porous scaffold
alginate
cryoelectrospinning
elastin
extracellular matrix
salivary gland
soft tissue engineering
Journal
Biofabrication
ISSN: 1758-5090
Titre abrégé: Biofabrication
Pays: England
ID NLM: 101521964
Informations de publication
Date de publication:
17 05 2022
17 05 2022
Historique:
received:
15
01
2022
accepted:
26
04
2022
pubmed:
29
4
2022
medline:
20
5
2022
entrez:
28
4
2022
Statut:
epublish
Résumé
Scaffold-based regenerative strategies that emulate physical, biochemical, and mechanical properties of the native extracellular matrix (ECM) of the region of interest can influence cell growth and function. Existing ECM-mimicking scaffolds, including nanofiber (NF) mats, sponges, hydrogels, and NF-hydrogel composites are unable to simultaneously mimic typical composition, topography, pore size, porosity, and viscoelastic properties of healthy soft-tissue ECM. In this work, we used cryoelectrospinning to fabricate 3D porous scaffolds with minimal fibrous backbone, pore size and mechanical properties similar to soft-tissue connective tissue ECM. We used salivary glands as our soft tissue model and found the decellularized adult salivary gland (DSG) matrix to have a fibrous backbone, 10-30
Identifiants
pubmed: 35481854
doi: 10.1088/1758-5090/ac6b34
pmc: PMC9973022
mid: NIHMS1873135
doi:
Substances chimiques
Alginates
0
Hydrogels
0
Solvents
0
Water
059QF0KO0R
Elastin
9007-58-3
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIDCR NIH HHS
ID : R01 DE027953
Pays : United States
Informations de copyright
© 2022 IOP Publishing Ltd.
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