Gain-of-Signal Assays for Probing Inhibition of SARS-CoV-2 M

Amino Acids Antiviral Agents / pharmacology Coronavirus 3C Proteases / antagonists & inhibitors Luciferases, Firefly Protease Inhibitors / pharmacology SARS-CoV-2 / drug effects
SARS-CoV-2 (SARS2) coronavirus gain-of-signal cell-based systems main protease (Mpro/3CLpro) viral protease inhibitors

Journal

mBio
ISSN: 2150-7511
Titre abrégé: mBio
Pays: United States
ID NLM: 101519231

Informations de publication

Date de publication:
28 06 2022
Historique:
pubmed: 27 4 2022
medline: 1 7 2022
entrez: 26 4 2022
Statut: ppublish

Résumé

The main protease, M

Identifiants

DOI: 10.1128/mbio.00784-22 PMID: 35471084 PMC: PMC9239272
pubmed: 35471084
doi: 10.1128/mbio.00784-22
pmc: PMC9239272
doi:

Substances chimiques

Amino Acids 0
Antiviral Agents 0
Protease Inhibitors 0
Luciferases, Firefly EC 1.13.12.7
3C-like proteinase, SARS-CoV-2 EC 3.4.22.-
Coronavirus 3C Proteases EC 3.4.22.28

Types de publication

Journal Article Research Support, Non-U.S. Gov't Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

e0078422

Subventions

Organisme : NIAID NIH HHS
ID : T32 AI083196
Pays : United States
Organisme : NIAID NIH HHS
ID : R37 AI064046
Pays : United States
Organisme : NIH HHS
ID : S10 OD025279
Pays : United States
Organisme : NIH HHS
ID : S10 OD026857
Pays : United States
Organisme : Howard Hughes Medical Institute
Pays : United States
Organisme : NCI NIH HHS
ID : P01 CA234228
Pays : United States
Organisme : NIAID NIH HHS
ID : F32 AI147813
Pays : United States
Organisme : NIGMS NIH HHS
ID : P30 GM124165
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM118047
Pays : United States
Organisme : NIH HHS
ID : S10 OD030330
Pays : United States
Organisme : NCRR NIH HHS
ID : S10 RR029205
Pays : United States

Commentaires et corrections

Type : UpdateOf

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Auteurs

Seyed Arad Moghadasi (SA)

Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesotagrid.17635.36, Minneapolis, Minnesota, USA.
Masonic Cancer Center, University of Minnesotagrid.17635.36, Minneapolis, Minnesota, USA.
Institute for Molecular Virology, University of Minnesotagrid.17635.36, Minneapolis, Minnesota, USA.

Morgan A Esler (MA)

Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesotagrid.17635.36, Minneapolis, Minnesota, USA.
Institute for Molecular Virology, University of Minnesotagrid.17635.36, Minneapolis, Minnesota, USA.

Yuka Otsuka (Y)

Department of Molecular Medicine, Scripps Research, The Scripps Research Molecular Screening Center, Jupiter, Florida, USA.

Jordan T Becker (JT)

Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesotagrid.17635.36, Minneapolis, Minnesota, USA.
Masonic Cancer Center, University of Minnesotagrid.17635.36, Minneapolis, Minnesota, USA.
Institute for Molecular Virology, University of Minnesotagrid.17635.36, Minneapolis, Minnesota, USA.

Sofia N Moraes (SN)

Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesotagrid.17635.36, Minneapolis, Minnesota, USA.
Masonic Cancer Center, University of Minnesotagrid.17635.36, Minneapolis, Minnesota, USA.
Institute for Molecular Virology, University of Minnesotagrid.17635.36, Minneapolis, Minnesota, USA.

Constance B Anderson (CB)

Department of Medicinal Chemistry, University of Minnesotagrid.17635.36, Minneapolis, Minnesota, USA.

Srinivas Chamakuri (S)

Center for Drug Discovery, Department of Pathology & Immunology, Baylor College of Medicine, Houston, Texas, USA.

Christopher Belica (C)

Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesotagrid.17635.36, Minneapolis, Minnesota, USA.
Masonic Cancer Center, University of Minnesotagrid.17635.36, Minneapolis, Minnesota, USA.
Institute for Molecular Virology, University of Minnesotagrid.17635.36, Minneapolis, Minnesota, USA.

Chloe Wick (C)

Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesotagrid.17635.36, Minneapolis, Minnesota, USA.
Masonic Cancer Center, University of Minnesotagrid.17635.36, Minneapolis, Minnesota, USA.
Institute for Molecular Virology, University of Minnesotagrid.17635.36, Minneapolis, Minnesota, USA.

Daniel A Harki (DA)

Masonic Cancer Center, University of Minnesotagrid.17635.36, Minneapolis, Minnesota, USA.
Department of Medicinal Chemistry, University of Minnesotagrid.17635.36, Minneapolis, Minnesota, USA.

Damian W Young (DW)

Center for Drug Discovery, Department of Pathology & Immunology, Baylor College of Medicine, Houston, Texas, USA.
Department of Pharmacology and Chemical Biology, Baylor College of Medicine, Houston, Texas, USA.
Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas, USA.

Louis Scampavia (L)

Department of Molecular Medicine, Scripps Research, The Scripps Research Molecular Screening Center, Jupiter, Florida, USA.

Timothy P Spicer (TP)

Department of Molecular Medicine, Scripps Research, The Scripps Research Molecular Screening Center, Jupiter, Florida, USA.

Ke Shi (K)

Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesotagrid.17635.36, Minneapolis, Minnesota, USA.
Masonic Cancer Center, University of Minnesotagrid.17635.36, Minneapolis, Minnesota, USA.
Institute for Molecular Virology, University of Minnesotagrid.17635.36, Minneapolis, Minnesota, USA.

Hideki Aihara (H)

Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesotagrid.17635.36, Minneapolis, Minnesota, USA.
Masonic Cancer Center, University of Minnesotagrid.17635.36, Minneapolis, Minnesota, USA.
Institute for Molecular Virology, University of Minnesotagrid.17635.36, Minneapolis, Minnesota, USA.

William L Brown (WL)

Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesotagrid.17635.36, Minneapolis, Minnesota, USA.
Masonic Cancer Center, University of Minnesotagrid.17635.36, Minneapolis, Minnesota, USA.
Institute for Molecular Virology, University of Minnesotagrid.17635.36, Minneapolis, Minnesota, USA.

Reuben S Harris (RS)

Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesotagrid.17635.36, Minneapolis, Minnesota, USA.
Masonic Cancer Center, University of Minnesotagrid.17635.36, Minneapolis, Minnesota, USA.
Institute for Molecular Virology, University of Minnesotagrid.17635.36, Minneapolis, Minnesota, USA.
Howard Hughes Medical Institute, University of Minnesotagrid.17635.36, Minneapolis, Minnesota, USA.
ORCID: 0000-0002-9034-9112

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Classifications MeSH

Recherchemedicale.com › Acides aminés, peptides et protéines › Acides aminés › Gain-of-Signal Assays for Probing Inhibition...
Recherchemedicale.com › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antiviraux › Gain-of-Signal Assays for Probing Inhibition...
Recherchemedicale.com › Acides aminés, peptides et protéines › Protéines › Protéines virales › Protéines virales non structurales › Protéases virales › Protéases virales 3C › Protéases 3C des coronavirus › Gain-of-Signal Assays for Probing Inhibition...
Recherchemedicale.com › Acides aminés, peptides et protéines › Protéines › Protéines luminescentes › Luciferases › Luciférases des lucioles › Gain-of-Signal Assays for Probing Inhibition...
Recherchemedicale.com › Actions chimiques et utilisations › Actions pharmacologiques › Mécanismes moléculaires de l'action pharmacologique › Antienzymes › Inhibiteurs de protéases › Gain-of-Signal Assays for Probing Inhibition...
Recherchemedicale.com › Virus › Virus à ARN › Virus à ARN à brin positif › Nidovirales › Coronaviridae › Coronavirus › Betacoronavirus › Virus du SRAS › SARS-CoV-2 › Gain-of-Signal Assays for Probing Inhibition...