Effects of heroin self-administration and forced withdrawal on the expression of genes related to the mTOR network in the basolateral complex of the amygdala of male Lewis rats.
Basolateral complex of the amygdala
Heroin
Incubation of seeking
Rictor
mTOR
Journal
Psychopharmacology
ISSN: 1432-2072
Titre abrégé: Psychopharmacology (Berl)
Pays: Germany
ID NLM: 7608025
Informations de publication
Date de publication:
Aug 2022
Aug 2022
Historique:
received:
20
10
2021
accepted:
11
04
2022
pubmed:
26
4
2022
medline:
22
7
2022
entrez:
25
4
2022
Statut:
ppublish
Résumé
The development of substance use disorders involves long-lasting adaptations in specific brain areas that result in an elevated risk of relapse. Some of these adaptations are regulated by the mTOR network, a signalling system that integrates extracellular and intracellular stimuli and modulates several processes related to plasticity. While the role of the mTOR network in cocaine- and alcohol-related disorders is well established, little is known about its participation in opiate use disorders. To use a heroin self-administration and a withdrawal protocol that induce incubation of heroin-seeking in male rats and study the associated effects on the expression of several genes related to the mTOR system and, in the specific case of Rictor, its respective translated protein and phosphorylation. We found that heroin self-administration elicited an increase in the expression of the genes Igf1r, Igf2r, Akt2 and Gsk3a in the basolateral complex of the amygdala, which was not as evident at 30 days of withdrawal. We also found an increase in the expression of Rictor (a protein of the mTOR complex 2) after heroin self-administration compared to the saline group, which was occluded at the 30-day withdrawal period. The activation levels of Rictor, measured by the phosphorylation rate, were also reduced after heroin self-administration, an effect that seemed more apparent in the protracted withdrawal group. These results suggest that heroin self-administration under extended access conditions modifies the expression profile of activators and components of the mTOR complexes and show a putative irresponsive mTOR complex 2 after withdrawal from heroin use.
Identifiants
pubmed: 35467104
doi: 10.1007/s00213-022-06144-2
pii: 10.1007/s00213-022-06144-2
pmc: PMC9293846
doi:
Substances chimiques
Heroin
70D95007SX
mTOR protein, rat
EC 2.7.1.1
TOR Serine-Threonine Kinases
EC 2.7.11.1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2559-2571Subventions
Organisme : Agencia Estatal de Investigación
ID : PID2019-104523RB-I00
Organisme : Agencia Estatal de Investigación
ID : PID2019-111594RB-100
Organisme : Secretaría de Estado de Investigación, Desarrollo e Innovación
ID : PSI2016-80541-P
Organisme : Instituto de Salud Carlos III
ID : RTA-RD16/020/0022
Organisme : Ministerio de Sanidad, Servicios Sociales e Igualdad
ID : 2016I073
Organisme : Ministerio de Sanidad, Servicios Sociales e Igualdad
ID : 2017I042
Organisme : Directorate-General for Justice
ID : JUST- 2017- AG- DRUG-806996-JUSTSO
Organisme : Universidad Nacional de Educación a Distancia
ID : Plan de Promoción de la Investigación
Informations de copyright
© 2022. The Author(s).
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