Neurological Music Therapy Rebuilds Structural Connectome after Traumatic Brain Injury: Secondary Analysis from a Randomized Controlled Trial.

DTI TBI connectometry executive function music therapy rehabilitation structural connectivity traumatic brain injury

Journal

Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588

Informations de publication

Date de publication:
14 Apr 2022
Historique:
received: 11 02 2022
revised: 06 04 2022
accepted: 11 04 2022
entrez: 23 4 2022
pubmed: 24 4 2022
medline: 24 4 2022
Statut: epublish

Résumé

Traumatic brain injury (TBI) is a common and devastating neurological condition, associated often with poor functional outcome and deficits in executive function. Due to the neuropathology of TBI, neuroimaging plays a crucial role in its assessment, and while diffusion MRI has been proposed as a sensitive biomarker, longitudinal studies evaluating treatment-related diffusion MRI changes are scarce. Recent evidence suggests that neurological music therapy can improve executive functions in patients with TBI and that these effects are underpinned by neuroplasticity changes in the brain. However, studies evaluating music therapy induced structural connectome changes in patients with TBI are lacking. Single-blind crossover (AB/BA) randomized controlled trial (NCT01956136). Here, we report secondary outcomes of the trial and set out to assess the effect of neurological music therapy on structural white matter connectome changes and their association with improved execute function in patients with TBI. Using an AB/BA design, 25 patients with moderate or severe TBI were randomized to receive a 3-month neurological music therapy intervention either during the first (AB, Compared to the control group, the music therapy group increased quantitative anisotropy (QA) in the right dorsal pathways (arcuate fasciculus, superior longitudinal fasciculus) and in the corpus callosum and the right frontal aslant tract, thalamic radiation and corticostriatal tracts. The mean increased QA in this network of results correlated with improved executive function. This study shows that music therapy can induce structural white matter neuroplasticity in the post-TBI brain that underpins improved executive function.

Sections du résumé

BACKGROUND BACKGROUND
Traumatic brain injury (TBI) is a common and devastating neurological condition, associated often with poor functional outcome and deficits in executive function. Due to the neuropathology of TBI, neuroimaging plays a crucial role in its assessment, and while diffusion MRI has been proposed as a sensitive biomarker, longitudinal studies evaluating treatment-related diffusion MRI changes are scarce. Recent evidence suggests that neurological music therapy can improve executive functions in patients with TBI and that these effects are underpinned by neuroplasticity changes in the brain. However, studies evaluating music therapy induced structural connectome changes in patients with TBI are lacking.
DESIGN METHODS
Single-blind crossover (AB/BA) randomized controlled trial (NCT01956136).
OBJECTIVE OBJECTIVE
Here, we report secondary outcomes of the trial and set out to assess the effect of neurological music therapy on structural white matter connectome changes and their association with improved execute function in patients with TBI.
METHODS METHODS
Using an AB/BA design, 25 patients with moderate or severe TBI were randomized to receive a 3-month neurological music therapy intervention either during the first (AB,
FINDINGS RESULTS
Compared to the control group, the music therapy group increased quantitative anisotropy (QA) in the right dorsal pathways (arcuate fasciculus, superior longitudinal fasciculus) and in the corpus callosum and the right frontal aslant tract, thalamic radiation and corticostriatal tracts. The mean increased QA in this network of results correlated with improved executive function.
CONCLUSIONS CONCLUSIONS
This study shows that music therapy can induce structural white matter neuroplasticity in the post-TBI brain that underpins improved executive function.

Identifiants

DOI: 10.3390/jcm11082184 PMID: 35456277 PMC: PMC9032739
pubmed: 35456277
pii: jcm11082184
doi: 10.3390/jcm11082184
pmc: PMC9032739
pii:
doi:

Banques de données

ClinicalTrials.gov
['NCT01956136']

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : Academy of Finland
ID : 277693
Organisme : Academy of Finland
ID : 299044
Organisme : Academy of Finland
ID : 306625
Organisme : European Research Council
ID : 803466
Pays : International
Organisme : University of Helsinki
ID : 313/51/2013
Organisme : Social Insurance Institution of Finland
ID : 18/26/2013
Organisme : Yrjö Johansson Foundation
ID : 6464
Organisme : Finnish Association of People with Physical Disabilities and Helsinki Uusimaa Hospital district
ID : 461/13/01/00/2015, 154/13/01/2016
Organisme : Finnish Cultural Foundation
ID : 191230
Organisme : Orion Research Foundation sr
Organisme : Maire Taponen Foundation
Organisme : Signe and Ane Gyllenberg Foundation

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Auteurs

Aleksi J Sihvonen (AJ)

Cognitive Brain Research Unit, Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, 00014 Helsinki, Finland.
Centre of Excellence in Music, Mind, Body and Brain, University of Jyväskylä & University of Helsinki, 00014 Helsinki, Finland.
School of Health and Rehabilitation Sciences, Queensland Aphasia Research Centre and UQ Centre for Clinical Research, The University of Queensland, Brisbane, QLD 4029, Australia.
ORCID: 0000-0002-4501-7338

Sini-Tuuli Siponkoski (ST)

Cognitive Brain Research Unit, Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, 00014 Helsinki, Finland.
Centre of Excellence in Music, Mind, Body and Brain, University of Jyväskylä & University of Helsinki, 00014 Helsinki, Finland.
ORCID: 0000-0001-8078-3620

Noelia Martínez-Molina (N)

Cognitive Brain Research Unit, Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, 00014 Helsinki, Finland.
Centre of Excellence in Music, Mind, Body and Brain, University of Jyväskylä & University of Helsinki, 00014 Helsinki, Finland.

Sari Laitinen (S)

Centre of Excellence in Music, Mind, Body and Brain, University of Jyväskylä & University of Helsinki, 00014 Helsinki, Finland.
Espoo Hospital, 02740 Espoo, Finland.

Milla Holma (M)

Independent Researcher, 00550 Helsinki, Finland.

Mirja Ahlfors (M)

Independent Researcher, 02330 Espoo, Finland.

Linda Kuusela (L)

Department of Physics, University of Helsinki, 00014 Helsinki, Finland.
HUS Medical Imaging Center, Department of Radiology, Helsinki Central University Hospital and University of Helsinki, 00014 Helsinki, Finland.

Johanna Pekkola (J)

HUS Medical Imaging Center, Department of Radiology, Helsinki Central University Hospital and University of Helsinki, 00014 Helsinki, Finland.

Sanna Koskinen (S)

Clinical Neuropsychology Research Group, Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, 00014 Helsinki, Finland.

Teppo Särkämö (T)

Cognitive Brain Research Unit, Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, 00014 Helsinki, Finland.
Centre of Excellence in Music, Mind, Body and Brain, University of Jyväskylä & University of Helsinki, 00014 Helsinki, Finland.

Classifications MeSH