SOD1 in ALS: Taking Stock in Pathogenic Mechanisms and the Role of Glial and Muscle Cells.
Ca2+ homeostasis
ROS signaling
SOD1
amyotrophic lateral sclerosis
reactive oxygen species
skeletal muscle
transgenic mice
Journal
Antioxidants (Basel, Switzerland)
ISSN: 2076-3921
Titre abrégé: Antioxidants (Basel)
Pays: Switzerland
ID NLM: 101668981
Informations de publication
Date de publication:
23 Mar 2022
23 Mar 2022
Historique:
received:
01
03
2022
revised:
18
03
2022
accepted:
19
03
2022
entrez:
23
4
2022
pubmed:
24
4
2022
medline:
24
4
2022
Statut:
epublish
Résumé
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by the loss of motor neurons in the brain and spinal cord. While the exact causes of ALS are still unclear, the discovery that familial cases of ALS are related to mutations in the Cu/Zn superoxide dismutase (SOD1), a key antioxidant enzyme protecting cells from the deleterious effects of superoxide radicals, suggested that alterations in SOD1 functionality and/or aberrant SOD1 aggregation strongly contribute to ALS pathogenesis. A new scenario was opened in which, thanks to the generation of SOD1 related models, different mechanisms crucial for ALS progression were identified. These include excitotoxicity, oxidative stress, mitochondrial dysfunctions, and non-cell autonomous toxicity, also implicating altered Ca
Identifiants
pubmed: 35453299
pii: antiox11040614
doi: 10.3390/antiox11040614
pmc: PMC9032988
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : University of Padova
ID : BIRD202151/20
Organisme : University of Padova
ID : RIGO_ALFREVE21_01 - Bando POR Veneto FESR 2014-2020
Organisme : University of Padova
ID : RIGO_FINA18_01 _ DSB, UNIPD
Organisme : MUR - Italian Ministry of Research
ID : RIGO_PRIV21_03_, Progetto MUR DM 1062/2021 PON "Ricerca e innovazione" 2014-2020
Références
Amyotroph Lateral Scler. 2012 Feb;13(2):166-77
pubmed: 22292840
Muscle Nerve. 2006 Jun;33(6):809-16
pubmed: 16583367
Amyotroph Lateral Scler. 2011 Mar;12(2):79-86
pubmed: 21241159
Curr Opin Neurobiol. 2011 Dec;21(6):904-19
pubmed: 21813273
J Neurol Sci. 2013 Aug 15;331(1-2):61-6
pubmed: 23764361
J Biol Chem. 1999 Sep 24;274(39):27590-6
pubmed: 10488097
J Biol Chem. 1995 Dec 15;270(50):29991-7
pubmed: 8530401
Front Neurosci. 2018 Jul 19;12:487
pubmed: 30072868
Free Radic Biol Med. 2007 May 15;42(10):1534-42
pubmed: 17448900
Amyotroph Lateral Scler Frontotemporal Degener. 2013 May;14(4):246-51
pubmed: 23286756
J Biol Chem. 2004 Nov 12;279(46):47998-8003
pubmed: 15326189
Lancet Neurol. 2018 May;17(5):416-422
pubmed: 29525492
Proc Natl Acad Sci U S A. 2019 Dec 17;116(51):25991-26000
pubmed: 31796595
Angew Chem Int Ed Engl. 2021 Apr 19;60(17):9215-9246
pubmed: 32144830
Amyotroph Lateral Scler. 2008;9(1):4-15
pubmed: 18273714
Front Mol Neurosci. 2018 Mar 22;11:87
pubmed: 29623030
Brain Pathol. 2016 Mar;26(2):237-47
pubmed: 26780365
Cell Metab. 2008 Nov;8(5):425-36
pubmed: 19046573
J Biol Chem. 2010 Jan 1;285(1):705-12
pubmed: 19889637
Prog Neurobiol. 2015 Oct;133:1-26
pubmed: 26253783
Antioxid Redox Signal. 2006 May-Jun;8(5-6):847-67
pubmed: 16771675
Biophys J. 2016 Apr 12;110(7):1499-1509
pubmed: 27074676
J Biol Chem. 2001 Feb 16;276(7):4647-51
pubmed: 11029464
Curr Neurol Neurosci Rep. 2006 Jan;6(1):37-46
pubmed: 16469270
EMBO Mol Med. 2015 Mar 27;7(5):526-46
pubmed: 25820275
J Physiol. 2008 Jul 15;586(14):3337-51
pubmed: 18467368
J Physiol. 2013 May 15;591(10):2723-45
pubmed: 23401612
Gene. 2016 Feb 15;577(2):109-18
pubmed: 26657039
Transl Neurodegener. 2020 Jul 1;9(1):23
pubmed: 32605607
Eur J Biochem. 2002 Apr;269(7):1905-15
pubmed: 11952792
J Neurol Sci. 1997 Oct;152 Suppl 1:S67-73
pubmed: 9419057
Mol Neurobiol. 2014 Apr;49(2):984-90
pubmed: 24198230
Neuroepidemiology. 2021;55(5):342-353
pubmed: 34247168
Science. 2015 Jun 5;348(6239):1151-4
pubmed: 25977373
Ann Neurol. 2001 Feb;49(2):267-71
pubmed: 11220750
Cell Death Dis. 2018 Feb 28;9(3):333
pubmed: 29491369
Skelet Muscle. 2011 Jan 24;1(1):3
pubmed: 21798081
Biochim Biophys Acta. 2016 Jun;1857(6):789-98
pubmed: 26947057
Proc Natl Acad Sci U S A. 1986 Jun;83(11):3820-4
pubmed: 3520557
Hum Mol Genet. 2019 Sep 1;28(17):2835-2850
pubmed: 31108504
Amyotroph Lateral Scler. 2009 Aug;10(4):221-8
pubmed: 19308767
Anal Bioanal Chem. 2017 Mar;409(8):2143-2153
pubmed: 28078418
Int J Mol Sci. 2021 Sep 16;22(18):
pubmed: 34576165
Skelet Muscle. 2016 Jun 23;6:24
pubmed: 27340545
Chem Cent J. 2013 Sep 05;7(1):150
pubmed: 24007191
Biochem Biophys Res Commun. 1997 Dec 18;241(2):251-7
pubmed: 9425258
Aging Dis. 2019 Dec 1;10(6):1199-1206
pubmed: 31788332
Neurodegener Dis. 2013;11(3):153-64
pubmed: 22797053
Acta Neuropathol. 2005 Mar;109(3):247-55
pubmed: 15614580
Biochem J. 2008 Sep 15;414(3):441-52
pubmed: 18518861
ACS Chem Neurosci. 2017 Sep 20;8(9):2019-2026
pubmed: 28585802
Curr Opin Neurol. 2019 Oct;32(5):771-776
pubmed: 31361627
Nat Biotechnol. 2011 Aug 10;29(9):824-8
pubmed: 21832997
Adv Neurobiol. 2017;16:117-136
pubmed: 28828608
Brain Res Bull. 2020 Jun;159:32-43
pubmed: 32247802
Genetics. 2003 Jan;163(1):35-46
pubmed: 12586694
Arch Biochem Biophys. 2004 Nov 15;431(2):207-14
pubmed: 15488469
J Cell Sci. 2016 Nov 1;129(21):4118-4129
pubmed: 27656112
Science. 1994 Jun 17;264(5166):1772-5
pubmed: 8209258
Neurosci Lett. 2003 Oct 23;350(2):132-6
pubmed: 12972170
Proc Natl Acad Sci U S A. 1994 Aug 16;91(17):8292-6
pubmed: 8058797
Nature. 1993 Mar 4;362(6415):59-62
pubmed: 8446170
Mech Ageing Dev. 2010 Jul-Aug;131(7-8):517-26
pubmed: 20493207
J Biol Chem. 1996 May 24;271(21):12275-80
pubmed: 8647826
J Pathol. 2020 Jan;250(1):67-78
pubmed: 31579943
Proc Natl Acad Sci U S A. 2004 Apr 20;101(16):5976-81
pubmed: 15056757
Muscle Nerve. 1978 Mar-Apr;1(2):133-9
pubmed: 155778
Mol Cell Neurosci. 1995 Aug;6(4):349-62
pubmed: 8846004
Biochemistry. 1999 Feb 16;38(7):2167-78
pubmed: 10026301
Int J Mol Sci. 2018 May 03;19(5):
pubmed: 29751510
J Neurosci. 2014 Feb 5;34(6):2331-48
pubmed: 24501372
Neurobiol Aging. 2015 Jan;36(1):492-504
pubmed: 25085783
N Engl J Med. 2001 May 31;344(22):1688-700
pubmed: 11386269
Neurobiol Dis. 2007 Nov;28(2):154-64
pubmed: 17766128
Proc Natl Acad Sci U S A. 2004 Apr 13;101(15):5518-23
pubmed: 15064408
Brain Res. 1995 Apr 3;676(1):25-40
pubmed: 7796176
J Biol Chem. 2013 May 31;288(22):15699-711
pubmed: 23592792
Proc Natl Acad Sci U S A. 1995 Mar 28;92(7):3024-8
pubmed: 7708768
J Neurosci Res. 2006 Jan;83(1):134-46
pubmed: 16323214
Int J Mol Sci. 2021 Nov 01;22(21):
pubmed: 34769284
Science. 2012 Jun 22;336(6088):1511-3
pubmed: 22723400
Nat Neurosci. 2007 May;10(5):608-14
pubmed: 17435754
Neurosci Biobehav Rev. 2022 Jan;132:976-997
pubmed: 34742724
Mol Cell. 2018 May 3;70(3):502-515.e8
pubmed: 29727620
Amyotroph Lateral Scler Frontotemporal Degener. 2018 Aug;19(5-6):438-445
pubmed: 29221425
Science. 2008 Mar 21;319(5870):1668-72
pubmed: 18309045
J Neurochem. 2001 Nov;79(4):737-46
pubmed: 11723166
Neuromuscul Disord. 2001 Nov;11(8):722-7
pubmed: 11595514
Int J Mol Sci. 2021 Jun 29;22(13):
pubmed: 34209958
Front Cell Neurosci. 2015 Aug 25;9:336
pubmed: 26379505
Oxid Med Cell Longev. 2020 Nov 15;2020:5021694
pubmed: 33274002
J Am Chem Soc. 2018 Dec 5;140(48):16570-16579
pubmed: 30359015
Neurobiol Dis. 2016 Sep;93:78-95
pubmed: 27151771
Biochem Biophys Res Commun. 2012 Jan 27;417(4):1275-9
pubmed: 22234310
Neurochem Int. 2017 Oct;109:184-192
pubmed: 28449871
FEBS Lett. 2006 Feb 6;580(3):878-84
pubmed: 16430889
Sci Rep. 2017 Jul 26;7(1):6521
pubmed: 28747684
J Neurochem. 2006 Mar;96(5):1349-61
pubmed: 16478527
Am J Pathol. 2004 Sep;165(3):719-28
pubmed: 15331397
Cell Mol Life Sci. 2014 Aug;71(15):2787-814
pubmed: 24442513
Neuropharmacology. 2020 May 1;167:107986
pubmed: 32062193
Proc Natl Acad Sci U S A. 1988 Jul;85(13):4789-93
pubmed: 3290902
Neurotherapeutics. 2014 Apr;11(2):419-32
pubmed: 24414863
Neurobiol Dis. 2021 Nov;159:105480
pubmed: 34411705
Proc Natl Acad Sci U S A. 2007 Sep 11;104(37):14825-30
pubmed: 17804792
J Alzheimers Dis. 2014;39(4):787-97
pubmed: 24270206
J Neurochem. 2006 Jun;97(6):1634-58
pubmed: 16805774
EMBO J. 2004 Jul 21;23(14):2872-81
pubmed: 15215895
J Biol Chem. 2015 Jan 23;290(4):2405-18
pubmed: 25433341
Trends Mol Med. 2011 Nov;17(11):659-67
pubmed: 21783422
Aging Cell. 2018 Dec;17(6):e12839
pubmed: 30295421
J Bacteriol. 1990 Apr;172(4):1840-5
pubmed: 2180907
Pathogens. 2014 Feb 18;3(1):149-63
pubmed: 25437612
Cell Calcium. 2018 Sep;74:102-111
pubmed: 30015245
Mol Neurobiol. 2004 Jun;29(3):229-42
pubmed: 15181236
CNS Drug Rev. 2006 Spring;12(1):9-20
pubmed: 16834755
Front Neurosci. 2017 Aug 30;11:476
pubmed: 28912673
J Biol Chem. 2013 Aug 30;288(35):25219-25228
pubmed: 23861388
Free Radic Biol Med. 2010 Apr 1;48(7):915-23
pubmed: 20079427
Front Cell Neurosci. 2015 Oct 28;9:416
pubmed: 26578881
J Neuropathol Exp Neurol. 1998 Jun;57(6):571-87
pubmed: 9630237
J Neurol. 2020 Nov;267(11):3258-3267
pubmed: 32556567
Nature. 2004 Feb 26;427(6977):801
pubmed: 14985749
Int J Mol Sci. 2021 Nov 12;22(22):
pubmed: 34830115
Front Physiol. 2018 Jul 10;9:831
pubmed: 30042688
Chin Med J (Engl). 2021 Oct 6;134(20):2457-2464
pubmed: 34669638
J Mol Med (Berl). 2005 Feb;83(2):110-20
pubmed: 15624111
Nat Rev Neurosci. 2006 Sep;7(9):710-23
pubmed: 16924260
Genes (Basel). 2020 Jul 11;11(7):
pubmed: 32664606
J Neurosci. 2013 Mar 13;33(11):4657-71
pubmed: 23486940
Nat Rev Neurosci. 2001 Nov;2(11):806-19
pubmed: 11715057
Brain Res. 2012 Nov 5;1483:112-7
pubmed: 23000195
Neuroreport. 1996 May 31;7(8):1427-31
pubmed: 8856691
Metallomics. 2016 Sep 1;8(9):1002-11
pubmed: 27357743
Hum Mol Genet. 2004 Oct 1;13(19):2183-96
pubmed: 15294873
Mol Neurobiol. 2021 Apr;58(4):1345-1371
pubmed: 33174130
J Biol Chem. 1973 Apr 25;248(8):2645-9
pubmed: 4697386
Proc Natl Acad Sci U S A. 1998 May 26;95(11):6361-6
pubmed: 9600970
Proc Natl Acad Sci U S A. 2006 Oct 24;103(43):16021-6
pubmed: 17043238
Nat Genet. 2021 Dec;53(12):1636-1648
pubmed: 34873335
EMBO J. 2010 Aug 18;29(16):2841-57
pubmed: 20606625
Front Neurol. 2020 Dec 14;11:592851
pubmed: 33381076
Mediators Inflamm. 2015;2015:537853
pubmed: 26491230
Proc Natl Acad Sci U S A. 2014 Mar 4;111(9):3620-5
pubmed: 24550511
Am J Physiol Cell Physiol. 2021 Apr 1;320(4):C465-C482
pubmed: 33296287
Ann Neurol. 1996 Feb;39(2):203-16
pubmed: 8967752
EMBO J. 2007 Jul 11;26(13):3169-79
pubmed: 17581637
Redox Biol. 2019 Feb;21:101064
pubmed: 30576923
J Neurol Sci. 2000 Aug 15;177(2):114-23
pubmed: 10980307
Proc Natl Acad Sci U S A. 2006 May 2;103(18):7148-53
pubmed: 16636274
Neurobiol Dis. 2007 Apr;26(1):1-13
pubmed: 17300945
Sci Adv. 2017 Dec 20;3(12):eaar3952
pubmed: 29279867
Int J Mol Sci. 2019 Oct 17;20(20):
pubmed: 31627428
J Mol Biol. 1982 Sep 15;160(2):181-217
pubmed: 7175933
Clin Chem Lab Med. 2006;44(5):589-93
pubmed: 16681429
Neuromuscul Disord. 2005 May;15(5):377-88
pubmed: 15833433
Hum Mol Genet. 2010 Jun 1;19(11):2284-302
pubmed: 20223753
Cochrane Database Syst Rev. 2002;(2):CD001447
pubmed: 12076411
J Mol Biol. 2007 Jan 12;365(2):333-42
pubmed: 17070542
J Biol Chem. 2001 Oct 12;276(41):38084-9
pubmed: 11500508
Hum Mol Genet. 2012 Feb 15;21(4):826-40
pubmed: 22072391
Nature. 2013 Mar 28;495(7442):467-73
pubmed: 23455423
Neurosci Lett. 2007 Nov 20;428(1):43-6
pubmed: 17942226
Front Cell Neurosci. 2015 Dec 01;9:463
pubmed: 26648847
Muscle Nerve. 2019 Feb;59(2):201-207
pubmed: 30192007
Int J Mol Sci. 2019 Sep 19;20(18):
pubmed: 31546771
Nature. 2016 Nov 10;539(7628):197-206
pubmed: 27830784
Redox Biol. 2015 Dec;6:260-271
pubmed: 26296072
Nat Neurosci. 2014 Jan;17(1):17-23
pubmed: 24369373
Aging Cell. 2018 Dec;17(6):e12831
pubmed: 30216632
Amyotroph Lateral Scler Other Motor Neuron Disord. 2000 Dec;1 Suppl 4:27-32
pubmed: 11466956
J Neurosci. 2012 Apr 4;32(14):4901-12
pubmed: 22492046
Front Cell Neurosci. 2021 Apr 01;15:653688
pubmed: 33867942
Nat Commun. 2014 Mar 19;5:3446
pubmed: 24647101
Pharmacol Res. 2018 Dec;138:25-36
pubmed: 30236524
Neurology. 2015 May 19;84(20):2033-9
pubmed: 25904686
Cell. 2013 Jan 17;152(1-2):224-35
pubmed: 23332757
Cells. 2022 Feb 17;11(4):
pubmed: 35203354
Cell Death Differ. 2018 Jun;25(6):1131-1145
pubmed: 29229997
Cell Calcium. 2010 Feb;47(2):165-74
pubmed: 20116097
J Biol Chem. 2004 Jul 30;279(31):32055-62
pubmed: 15166213
Elife. 2020 Mar 26;9:
pubmed: 32213287
Cell Calcium. 2011 Apr;49(4):217-25
pubmed: 21388680
Brain Res. 2018 Aug 15;1693(Pt A):1-10
pubmed: 29577886
J Biol Chem. 1996 Nov 15;271(46):28831-6
pubmed: 8910528
Med Genet. 2018;30(2):252-258
pubmed: 30220791
Pharmacol Res. 2015 Sep;99:377-81
pubmed: 26013908
Cells. 2021 Jun 09;10(6):
pubmed: 34207859
Lancet Neurol. 2017 Jul;16(7):505-512
pubmed: 28522181
Am J Pathol. 1994 Dec;145(6):1271-9
pubmed: 7992831
J Am Chem Soc. 2010 Sep 29;132(38):13495-504
pubmed: 20822138
Amyotroph Lateral Scler Frontotemporal Degener. 2016 Jul-Aug;17(5-6):443-51
pubmed: 26892977
Proc Natl Acad Sci U S A. 2022 Jan 4;119(1):
pubmed: 34969852
Lancet Neurol. 2013 May;12(5):435-42
pubmed: 23541756
Biochim Biophys Acta. 2015 Dec;1849(12):1398-410
pubmed: 26514432
Proc Natl Acad Sci U S A. 1994 Oct 11;91(21):9906-10
pubmed: 7937915
Cell Biol Int. 2007 Jun;31(6):546-53
pubmed: 17241791
J Biol Chem. 2019 Mar 8;294(10):3744-3759
pubmed: 30635404
Oxid Med Cell Longev. 2013;2013:408681
pubmed: 23533690
Amyotroph Lateral Scler Other Motor Neuron Disord. 2001 Mar;2 Suppl 1:S47-54
pubmed: 11465925
Neuron. 1997 Feb;18(2):327-38
pubmed: 9052802
J Biol Chem. 2012 Jan 20;287(4):2719-30
pubmed: 22110130
Brain Res. 2006 Apr 14;1083(1):196-203
pubmed: 16546142
Biochim Biophys Acta. 2006 Nov-Dec;1762(11-12):1013-24
pubmed: 16675207
Neurobiol Dis. 2011 Jun;42(3):265-75
pubmed: 21296666
J Neuroinflammation. 2015 Jun 28;12:127
pubmed: 26126965