Discordant Antibody and T-Cell Responses to the Severe Acute Respiratory Syndrome Coronavirus 2 Omicron Variant in Coronavirus Disease 2019 Messenger RNA Vaccine Recipients.
COVID-19
Omicron
SARS-CoV-2
T cells
antibodies
Journal
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
ISSN: 1537-6591
Titre abrégé: Clin Infect Dis
Pays: United States
ID NLM: 9203213
Informations de publication
Date de publication:
29 10 2022
29 10 2022
Historique:
received:
04
02
2022
pubmed:
20
4
2022
medline:
2
11
2022
entrez:
19
4
2022
Statut:
ppublish
Résumé
We compared antibody and T-cell responses against the severe acute respiratory syndrome coronavirus 2 vaccine strain spike protein to responses against the Omicron variant in 15 messenger RNA vaccine recipients. While these individuals had significantly lower levels of antibodies that inhibited Omicron spike protein binding to ACE2, there was no difference in T-cell responses.
Identifiants
pubmed: 35438751
pii: 6570698
doi: 10.1093/cid/ciac305
pmc: PMC9047215
doi:
Substances chimiques
COVID-19 Vaccines
0
RNA, Messenger
0
Antibodies, Viral
0
Antibodies, Neutralizing
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
1652-1654Subventions
Organisme : NIAID NIH HHS
ID : K08 AI156021
Pays : United States
Organisme : NCI NIH HHS
ID : U54CA260491
Pays : United States
Informations de copyright
© The Author(s) 2022. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
Déclaration de conflit d'intérêts
Potential conflicts of interest. A. L. C. reports support from the National Institutes of Health for the present manuscript and outside of the submitted work and consulting fees from Janssen paid to hepatitis B virus cure strategies. A. H. K. reports consulting fees from Roche. All other authors report no potential conflicts of interest. All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Conflicts that the editors consider relevant to the content of the manuscript have been disclosed.