Design, Synthesis, Pharmacodynamic and

Animals Calcium Channel Blockers / chemistry Calcium Channels Dogs Molecular Structure Pyrimidines / chemistry Structure-Activity Relationship
Biginelli calcium channel blockers hypotensive activity pyrimidines

Journal

Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009

Informations de publication

Date de publication:
30 Mar 2022
Historique:
received: 10 02 2022
revised: 21 03 2022
accepted: 25 03 2022
entrez: 12 4 2022
pubmed: 13 4 2022
medline: 14 4 2022
Statut: epublish

Résumé

Some new pyrimidine derivatives comprising arylsulfonylhydrazino, ethoxycarbonylhydrazino, thiocarbamoylhydrazino and substituted hydrazone and thiosemicarbazide functionalities were prepared from Biginelli-derived pyrimidine precursors. Heterocyclic ring systems such as pyrazole, pyrazolidinedione, thiazoline and thiazolidinone ring systems were also incorporated into the designed pyrimidine core. Furthermore, fused triazolopyrimidine and pyrimidotriazine ring systems were prepared. The synthesized compounds were evaluated for their calcium channel blocking activity as potential hypotensive agents. Compounds

Identifiants

DOI: 10.3390/molecules27072240 PMID: 35408650 PMC: PMC9000669
pubmed: 35408650
pii: molecules27072240
doi: 10.3390/molecules27072240
pmc: PMC9000669
pii:
doi:

Substances chimiques

Calcium Channel Blockers 0
Calcium Channels 0
Pyrimidines 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Princess Nourah bint Abdulrahman University
ID : PNURSP2022R86

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Auteurs

Ahmed M Farghaly (AM)

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria 21521, Egypt.

Ola H Rizk (OH)

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria 21521, Egypt.
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Pharos University, Alexandria 21521, Egypt.
ORCID: 0000-0002-0278-0376

Inas Darwish (I)

Department of Clinical Pharmacology, Faculty of Medicine, Alexandria University, Alexandria 21521, Egypt.
Department of Pharmacology and Therapeutics, Faculty of Pharmacy, Pharos University, Alexandria 21521, Egypt.

Manal Hamza (M)

Department of Clinical Pharmacology, Faculty of Medicine, Alexandria University, Alexandria 21521, Egypt.

Mezna Saleh Altowyan (MS)

Department of Chemistry, College of Science, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia.
ORCID: 0000-0002-7038-8018

Assem Barakat (A)

Department of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia.
Department of Chemistry, Faculty of Science, Alexandria University, P.O. Box 426, Ibrahimia, Alexandria 21321, Egypt.
ORCID: 0000-0002-7885-3201

Mohamed Teleb (M)

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria 21521, Egypt.

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Classifications MeSH

Recherchemedicale.com › Eucaryotes › Animaux › Design, Synthesis, Pharmacodynamic and
Recherchemedicale.com › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents cardiovasculaires › Inhibiteurs des canaux calciques › Design, Synthesis, Pharmacodynamic and
Recherchemedicale.com › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Canaux ioniques › Canaux calciques › Design, Synthesis, Pharmacodynamic and
Recherchemedicale.com › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Carnivora › Pinnipedia › Canidae › Chiens › Design, Synthesis, Pharmacodynamic and
Recherchemedicale.com › Phénomènes chimiques › Structure moléculaire › Design, Synthesis, Pharmacodynamic and
Recherchemedicale.com › Composés hétérocycliques › Composés hétéromonocycliques › Pyrimidines › Design, Synthesis, Pharmacodynamic and
Recherchemedicale.com › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › Design, Synthesis, Pharmacodynamic and