The hexosamine pathway and coat complex II promote malignant adaptation to nutrient scarcity.
Journal
Life science alliance
ISSN: 2575-1077
Titre abrégé: Life Sci Alliance
Pays: United States
ID NLM: 101728869
Informations de publication
Date de publication:
07 2022
07 2022
Historique:
received:
10
12
2021
revised:
23
03
2022
accepted:
24
03
2022
entrez:
9
4
2022
pubmed:
10
4
2022
medline:
13
4
2022
Statut:
epublish
Résumé
The glucose-requiring hexosamine biosynthetic pathway (HBP), which produces UDP-N-acetylglucosamine for glycosylation reactions, promotes lung adenocarcinoma (LUAD) progression. However, lung tumor cells often reside in low-nutrient microenvironments, and whether the HBP is involved in the adaptation of LUAD to nutrient stress is unknown. Here, we show that the HBP and the coat complex II (COPII) play a key role in cell survival during glucose shortage. HBP up-regulation withstood low glucose-induced production of proteins bearing truncated
Identifiants
pubmed: 35396334
pii: 5/7/e202101334
doi: 10.26508/lsa.202101334
pmc: PMC9008580
pii:
doi:
Substances chimiques
Hexosamines
0
ErbB Receptors
EC 2.7.10.1
Glucose
IY9XDZ35W2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2022 Dragic et al.
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